CD47 Promising News

[KDR]

http://www.zmescience.com/medicine/diseases-medicine/drug-cancer-cd47-28032014/


I know this might belong on the Articles thread where I posted a similar article the other day, but it was so thrilling, I thought I'd put it here.

Karen

[KDR]

http://stemcell.stanford.edu/CD47/
Last night's notification that Phase I trials may not start this spring, but summer or early fall. Could it be?

Karen

[Carol Ann]

This is fantastic news, Karen, thanks for posting this!

Carol Ann

[Nurse4u2day]

This is very promising news!

[Coux92]

Wow! Do we dare hope? It sounds so encouraging. Thank you Karen for posting :-)

[KDR]

http://news.stanford.edu/news/2014/january/ludwig-gift-cancer-010614.html

Metastatic patients, find your happy news in the lower half of article.

Karen

[Jackie07]

The idea started almorst 20 years ago... Glad it's finally going to be put to 'test'.

J Cell Sci. 1995 Nov;108 ( Pt 11):3419-25.
In vivo expression of alternatively spliced forms of integrin-associated protein (CD47).
Reinhold MI1, Lindberg FP, Plas D, Reynolds S, Peters MG, Brown EJ.
Author information
Abstract
Integrin-associated protein (IAP) is a 50 kDa plasma membrane protein physically and functionally associated with beta 3 integrins in a variety of cells. IAP has an extracellular immunoglobulin domain, five transmembrane domains and a short intracytoplasmic tail. IAP is recognized by anti-CD47 antibodies and is expressed on cells, such as erythrocytes and lymphocytes, which do not express beta 3 integrins. To learn more about potential functions of IAP we examined its expression in vivo. Using the polymerase chain reaction, we detected 4 alternatively splice forms of IAP which differ from each other only at their intracytoplasmic carboxy termini. These alternatively spliced forms are generated by inclusion or exclusion of three short exons within 5 kb in the genome and are highly conserved between mouse and man. There is tissue specificity of expression of the alternatively spliced forms of IAP mRNA, with bone marrow-derived cells expressing predominantly one form and neural tissue another. Using polyclonal antibodies which recognize the alternatively spliced bone marrow (form 2) and neural (form 4) forms of IAP, we found that in accord with the mRNA, form 2 protein was expressed in all tissues primarily on bone marrow-derived cells and endothelia, while form 4 was highly expressed in the brain and peripheral nervous system. The evolutionary conservation of IAP isoforms and their tissue-specific expression suggest an important role for these intracytoplasmic domains in IAP function.

[CarolineC]

Karen, thank you for your posts which always give me so much hope!

[Andrea Barnett Budin]

There's an ARTICLES section?

Go know...

I love that you posted here, where I go, and with such positivity for all our Sisters! Thank you, Karen.

Did I mention, I love you?

ANDI

[KDR]

Love you back, but you knew that...AND there's a reason your posts are five-star rated, dear Andi!
Karen
Who Believes In The Cure