review article on her2+ER+ subtypes, treatment response

[Lani]

http://annonc.oxfordjournals.org/content/24/11/2715.full.pdf+html

discusses research looking at whether/how to ID those who may benefit from chemo free therapy ie anti-hormonal+anti-her2 agents only

[Aussie Girl]

Interesting article,Lani - thanks

Aussie Girl

['lizbeth]

I just got to the article, and am chewing on all the information inside - finding the groups of women who do not benefit from chemo and matching them with the treatments that benefit them with the least side effects and the longest overall survival.

Beautiful, just beautiful!

[Lien]

Interesting. I'm not very well at the moment, (not cancer related as far as I know) so I have trouble reading the whole article. I'm wondering how this would translate to non-metastatic disease.

Jacqueline

['lizbeth]

The article is so full of information. I could not digest it in one sitting either.


For non-metastatic disease, take a look at Table 2 with the neoadjuvant phase III studies on page 3. It shows Overall pCR, then separates into HR positive and HR negative response rates.


The HR negatives show a high response rate of 63.2 with Docetaxel, Herceptin and Perjeta. A similar high response rate is obtained with Paclitaxel, Herceptin and Tykerb.


HR positive pCR was highest with Paclitaxel, Herceptin and Tykerb at 41.6 percent.


What I find most heartbreaking is table 3 on page 7 is that Letrozole and Herceptin for first line Metastatic Breast Cancer had a clinical benefit rate of 65 percent and helped women obtained 14.1 months of progression free survival - 6 months longer then the next combination, yet the trial closed early due to slow accrual.

[Lien]

Thanks 'Lizbeth, I'll check it out when my brain is less foggy.


Jacqueline

['lizbeth]

Sorry that you don't feel well Jacqueline! Hope you recover quickly.

[Lien]

Thanks 'lizbeth, but that's not likely. I've been struggling with something that very much resembles Chronic Fatigue Syndrome for 14 months now. Unfortunately my doc thinks it's between my ears, so I've been treated for stress. It seemed to help, a bit, but then it came back. And again. Sigh. Trying to find the right doc who is willing to investigate.

Jacqueline

['lizbeth]

I felt tired all the time until I found Dr. Joe - he put me through 6 hours of physical therapy a week. It was rough, but he was the right doctor to help me regain quality of life. A true miracle worker - I hope you find the right doctor, and the one is right, part of it could be between your ears - cognitive fatigue is very exhausting.

Sending you a cyber hug {hug}.

[Lien]

Hi 'lizbeth,
This is different. I have had severe allergies and intolerance since long before my BC diagnosis. Sometimes I feel fine, and within an hour I can be a total wreck, because I've inhaled or eaten something wrong. I know that stress makes my symptoms worse, but it is not what caused my problems. All the stress treatments I tried worked well for the stress, but not for my pain, fatigue and brain fog. Even when I'm perfectly happy and relaxed, it can suddenly hit me. I exercise plenty, as I live in the Netherlands, Europe and do 90% of my shopping by bicycle.

Jacqueline

['lizbeth]

Jacqueline,

I got lucky and connected with the right doctor. I hope that you do too.

My husband's family has severe allergies - my great nephew is like you and seems to be allergic to a large number of things. Allergies can be devastating, or subtle and still make you miserable.

My husband can't walk into a candle shop - the sneezing fit is spectacular and lengthy.

I used to live in a little town where you walked or biked most places. I loved it. Now I live in the big city and have to rely on a car to get most places.

I hope you find the right doctor soon - so that you gain back your energy and good health.