Lani
07-05-2012, 07:31 AM
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
2012, DOI: 10.1007/s00432-012-1267-2
ORIGINAL PAPER
Radioembolization using Yttrium-90 microspheres in 58 patients with liver metastases from breast cancer
Changming Shen, Xueling Yang, Aisidi Tecle, Cheng Tian and Qiang Li
Link Out to this Article at Stanford University Libraries:
Download PDF (215.5 KB)View HTMLPermissions & Reprints
Journal
Search Within This Journal
Browse This Journal
Online First™
Open Access
Samples
Contemporary Content
Volume 138
1081-1257Number 7 / July 2012
901-1079Number 6 / June 2012
723-899Number 5 / May 2012
545-722Number 4 / April 2012
363-544Number 3 / March 2012
179-361Number 2 / February 2012
1-178Number 1 / January 2012
1-162Supplement 1 / February 2012
Volume 137
1729-1874Number 12 / December 2011
1587-1727Number 11 / November 2011
1409-1585Number 10 / October 2011
1283-1408Number 9 / September 2011
1151-1282Number 8 / August 2011
1053-1150Number 7 / July 2011
915-1051Number 6 / June 2011
739-913Number 5 / May 2011
557-738Number 4 / April 2011
375-555Number 3 / March 2011
183-374Number 2 / February 2011
1-181Number 1 / January 2011
Volume 136
1787-1944Number 12 / December 2010
1627-1785Number 11 / November 2010
1461-1626Number 10 / October 2010
1295-1460Number 9 / September 2010
1117-1294Number 8 / August 2010
961-1116Number 7 / July 2010
795-959Number 6 / June 2010
639-793Number 5 / May 2010
483-637Number 4 / April 2010
333-481Number 3 / March 2010
173-331Number 2 / February 2010
1-171Number 1 / January 2010
Volume 135
1637-1807Number 12 / December 2009
1473-1636Number 11 / November 2009
1303-1471Number 10 / October 2009
1137-1302Number 9 / September 2009
969-1136Number 8 / August 2009
855-967Number 7 / July 2009
749-854Number 6 / June 2009
653-747Number 5 / May 2009
491-651Number 4 / April 2009
327-490Number 3 / March 2009
163-326Number 2 / February 2009
1-162Number 1 / January 2009
Volume 134
1267-1405Number 12 / December 2008
1155-1265Number 11 / November 2008
1043-1153Number 10 / October 2008
929-1042Number 9 / September 2008
821-928Number 8 / August 2008
725-820Number 7 / July 2008
631-723Number 6 / June 2008
525-630Number 5 / May 2008
427-524Number 4 / April 2008
281-426Number 3 / March 2008
119-279Number 2 / February 2008
1-118Number 1 / January 2008
Volume 133
905-1025Number 12 / December 2007
793-903Number 11 / November 2007
679-791Number 10 / October 2007
581-678Number 9 / September 2007
501-579Number 8 / August 2007
417-500Number 7 / July 2007
343-415Number 6 / June 2007
279-341Number 5 / May 2007
213-278Number 4 / April 2007
145-211Number 3 / March 2007
71-144Number 2 / February 2007
1-70Number 1 / January 2007
Volume 132
757-823Number 12 / December 2006
685-755Number 11 / November 2006
617-683Number 10 / October 2006
547-616Number 9 / September 2006
483-546Number 8 / August 2006
417-481Number 7 / July 2006
343-416Number 6 / June 2006
275-342Number 5 / May 2006
205-274Number 4 / April 2006
137-204Number 3 / March 2006
69-135Number 2 / February 2006
1-68Number 1 / January 2006
1-35Supplement 1 / August 2006
Volume 131
773-836Number 12 / December 2005
701-771Number 11 / November 2005
631-700Number 10 / October 2005
559-630Number 9 / September 2005
487-558Number 8 / August 2005
407-485Number 7 / July 2005
333-406Number 6 / June 2005
271-331Number 5 / May 2005
205-269Number 4 / April 2005
137-203Number 3 / March 2005
73-136Number 2 / February 2005
1-72Number 1 / January 2005
Volume 130
695-761Number 12 / December 2004
627-693Number 11 / November 2004
561-625Number 10 / October 2004
497-560Number 9 / September 2004
429-495Number 8 / August 2004
367-428Number 7 / July 2004
307-366Number 6 / June 2004
245-305Number 5 / May 2004
187-243Number 4 / April 2004
127-186Number 3 / March 2004
57-125Number 2 / February 2004
1-56Number 1 / January 2004
Supplement 1 / January 2004
Volume 129
669-736Number 12 / December 2003
607-668Number 11 / November 2003
549-605Number 10 / October 2003
493-548Number 9 / September 2003
437-491Number 8 / August 2003
375-436Number 7 / July 2003
321-373Number 6 / June 2003
263-319Number 5 / May 2003
199-261Number 4 / April 2003
133-198Number 3 / March 2003
71-131Number 2 / February 2003
1-69Number 1 / January 2003
Supplement 2 / September 2003
Supplement 1 / January 2003
Volume 128
633-696Number 12 / December 2002
581-631Number 11 / November 2002
525-580Number 10 / October 2002
461-524Number 9 / September 2002
403-460Number 8 / August 2002
343-401Number 7 / July 2002
295-342Number 6 / June 2002
235-293Number 5 / May 2002
177-234Number 4 / April 2002
119-176Number 3 / March 2002
65-118Number 2 / February 2002
1-63Number 1 / January 2002
Supplement 1 / January 2002
Volume 127
Supplement 2 / October 2001
697-754Number 12 / December 2001
643-695Number 11 / November 2001
583-641Number 10 / October 2001
521-581Number 9 / September 2001
463-519Number 8 / August 2001
405-462Number 7 / July 2001
331-404Number 6 / May 2001
269-329Number 5 / April 2001
207-268Number 4 / March 2001
143-206Number 3 / February 2001
73-142Number 2 / January 2001
1-72Number 1 / January 2001
Supplement 2 / October 2001
Supplement 1 / January 2001
Volume 126
671-733Number 12 / November 2000
607-670Number 11 / October 2000
549-606Number 10 / September 2000
487-548Number 9 / August 2000
425-485Number 8 / July 2000
361-423Number 7 / June 2000
305-359Number 6 / May 2000
247-304Number 5 / April 2000
185-246Number 4 / March 2000
125-184Number 3 / February 2000
69-123Number 2 / January 2000
1-67Number 1 / January 2000
Supplement 1 / January 2000
Volume 125
653-711Number 12 / November 1999
589-652Number 11 / October 1999
529-587Number 10 / September 1999
439-528Numbers 8-9 / August 1999
379-438Number 7 / June 1999
321-377Number 6 / May 1999
257-320Number 5 / May 1999
121-256Numbers 3-4 / April 1999
61-120Number 2 / March 1999
1-60Number 1 / January 1999
Volume 124
643-700Number 12 / December 1998
585-641Number 11 / November 1998
527-583Number 10 / October 1998
471-525Number 9 / September 1998
409-469Number 8 / August 1998
353-408Number 7 / July 1998
291-351Number 6 / July 1998
231-290Number 5 / May 1998
131-230Numbers 3-4 / April 1998
65-130Number 2 / March 1998
1-64Number 1 / February 1998
Volume 123
581-680Numbers 11-12 / December 1997
531-579Number 10 / October 1997
467-530Number 9 / December 1997
413-466Number 8 / August 1997
363-412Number 7 / July 1997
301-362Number 6 / June 1997
243-299Number 5 / May 1997
189-242Number 4 / April 1997
133-187Number 3 / March 1997
71-132Number 2 / February 1997
1-70Number 1 / January 1997
Supplement 1 / January 1997
Scroll upScroll down
Archival Content
REFERENCES (17)EXPORT CITATIONABOUT
Abstract
Purpose
To evaluate clinical outcomes associated with single-session, whole-liver radioembolization with Yttrium-90 (90Y)-labeled resin microspheres in patients with nonresectable liver metastases from breast cancer that were refractory to other treatments.
Methods
A retrospective analysis of consecutive patients who were treated between January 2002 and October 2008 was performed. Fifty-eight patients with unresectable liver metastases from breast cancer who had a good performance status and a low burden of extrahepatic disease were eligible for RE. Patients had undergone polychemotherapy regimens including at least anthracyclines and taxanes, hormonal therapy, and trastuzumab were applicable.
Results
A median activity of 1.93 GBq of 90Y was delivered. Follow-up at a median of 4.2 months demonstrated complete response, partial response, stable disease, and progressive disease in 5, 52, 31, and 12 % of patients, respectively. With respect to tumor diameters, imaging revealed a maximum and minimum response of −57.6 to +25.8 %, respectively. The median overall survival was 12.3 months. The median survival of responders and nonresponders was 20.9 and 6.3 months, respectively, and the median survival of patients with and patients without extrahepatic disease was 8.3 and 16.2 months, respectively. Clinically significant toxicities with the appearance of increasing transaminase level, increasing bilirubin level, nausea and vomiting, gastric ulcers, and ascites.
Conclusions
Single-session, whole-liver 90Y radioembolization can be performed with an acceptable toxicity profile in patients with liver metastases from breast cancer.
2012, DOI: 10.1007/s00432-012-1267-2
ORIGINAL PAPER
Radioembolization using Yttrium-90 microspheres in 58 patients with liver metastases from breast cancer
Changming Shen, Xueling Yang, Aisidi Tecle, Cheng Tian and Qiang Li
Link Out to this Article at Stanford University Libraries:
Download PDF (215.5 KB)View HTMLPermissions & Reprints
Journal
Search Within This Journal
Browse This Journal
Online First™
Open Access
Samples
Contemporary Content
Volume 138
1081-1257Number 7 / July 2012
901-1079Number 6 / June 2012
723-899Number 5 / May 2012
545-722Number 4 / April 2012
363-544Number 3 / March 2012
179-361Number 2 / February 2012
1-178Number 1 / January 2012
1-162Supplement 1 / February 2012
Volume 137
1729-1874Number 12 / December 2011
1587-1727Number 11 / November 2011
1409-1585Number 10 / October 2011
1283-1408Number 9 / September 2011
1151-1282Number 8 / August 2011
1053-1150Number 7 / July 2011
915-1051Number 6 / June 2011
739-913Number 5 / May 2011
557-738Number 4 / April 2011
375-555Number 3 / March 2011
183-374Number 2 / February 2011
1-181Number 1 / January 2011
Volume 136
1787-1944Number 12 / December 2010
1627-1785Number 11 / November 2010
1461-1626Number 10 / October 2010
1295-1460Number 9 / September 2010
1117-1294Number 8 / August 2010
961-1116Number 7 / July 2010
795-959Number 6 / June 2010
639-793Number 5 / May 2010
483-637Number 4 / April 2010
333-481Number 3 / March 2010
173-331Number 2 / February 2010
1-171Number 1 / January 2010
Volume 135
1637-1807Number 12 / December 2009
1473-1636Number 11 / November 2009
1303-1471Number 10 / October 2009
1137-1302Number 9 / September 2009
969-1136Number 8 / August 2009
855-967Number 7 / July 2009
749-854Number 6 / June 2009
653-747Number 5 / May 2009
491-651Number 4 / April 2009
327-490Number 3 / March 2009
163-326Number 2 / February 2009
1-162Number 1 / January 2009
Volume 134
1267-1405Number 12 / December 2008
1155-1265Number 11 / November 2008
1043-1153Number 10 / October 2008
929-1042Number 9 / September 2008
821-928Number 8 / August 2008
725-820Number 7 / July 2008
631-723Number 6 / June 2008
525-630Number 5 / May 2008
427-524Number 4 / April 2008
281-426Number 3 / March 2008
119-279Number 2 / February 2008
1-118Number 1 / January 2008
Volume 133
905-1025Number 12 / December 2007
793-903Number 11 / November 2007
679-791Number 10 / October 2007
581-678Number 9 / September 2007
501-579Number 8 / August 2007
417-500Number 7 / July 2007
343-415Number 6 / June 2007
279-341Number 5 / May 2007
213-278Number 4 / April 2007
145-211Number 3 / March 2007
71-144Number 2 / February 2007
1-70Number 1 / January 2007
Volume 132
757-823Number 12 / December 2006
685-755Number 11 / November 2006
617-683Number 10 / October 2006
547-616Number 9 / September 2006
483-546Number 8 / August 2006
417-481Number 7 / July 2006
343-416Number 6 / June 2006
275-342Number 5 / May 2006
205-274Number 4 / April 2006
137-204Number 3 / March 2006
69-135Number 2 / February 2006
1-68Number 1 / January 2006
1-35Supplement 1 / August 2006
Volume 131
773-836Number 12 / December 2005
701-771Number 11 / November 2005
631-700Number 10 / October 2005
559-630Number 9 / September 2005
487-558Number 8 / August 2005
407-485Number 7 / July 2005
333-406Number 6 / June 2005
271-331Number 5 / May 2005
205-269Number 4 / April 2005
137-203Number 3 / March 2005
73-136Number 2 / February 2005
1-72Number 1 / January 2005
Volume 130
695-761Number 12 / December 2004
627-693Number 11 / November 2004
561-625Number 10 / October 2004
497-560Number 9 / September 2004
429-495Number 8 / August 2004
367-428Number 7 / July 2004
307-366Number 6 / June 2004
245-305Number 5 / May 2004
187-243Number 4 / April 2004
127-186Number 3 / March 2004
57-125Number 2 / February 2004
1-56Number 1 / January 2004
Supplement 1 / January 2004
Volume 129
669-736Number 12 / December 2003
607-668Number 11 / November 2003
549-605Number 10 / October 2003
493-548Number 9 / September 2003
437-491Number 8 / August 2003
375-436Number 7 / July 2003
321-373Number 6 / June 2003
263-319Number 5 / May 2003
199-261Number 4 / April 2003
133-198Number 3 / March 2003
71-131Number 2 / February 2003
1-69Number 1 / January 2003
Supplement 2 / September 2003
Supplement 1 / January 2003
Volume 128
633-696Number 12 / December 2002
581-631Number 11 / November 2002
525-580Number 10 / October 2002
461-524Number 9 / September 2002
403-460Number 8 / August 2002
343-401Number 7 / July 2002
295-342Number 6 / June 2002
235-293Number 5 / May 2002
177-234Number 4 / April 2002
119-176Number 3 / March 2002
65-118Number 2 / February 2002
1-63Number 1 / January 2002
Supplement 1 / January 2002
Volume 127
Supplement 2 / October 2001
697-754Number 12 / December 2001
643-695Number 11 / November 2001
583-641Number 10 / October 2001
521-581Number 9 / September 2001
463-519Number 8 / August 2001
405-462Number 7 / July 2001
331-404Number 6 / May 2001
269-329Number 5 / April 2001
207-268Number 4 / March 2001
143-206Number 3 / February 2001
73-142Number 2 / January 2001
1-72Number 1 / January 2001
Supplement 2 / October 2001
Supplement 1 / January 2001
Volume 126
671-733Number 12 / November 2000
607-670Number 11 / October 2000
549-606Number 10 / September 2000
487-548Number 9 / August 2000
425-485Number 8 / July 2000
361-423Number 7 / June 2000
305-359Number 6 / May 2000
247-304Number 5 / April 2000
185-246Number 4 / March 2000
125-184Number 3 / February 2000
69-123Number 2 / January 2000
1-67Number 1 / January 2000
Supplement 1 / January 2000
Volume 125
653-711Number 12 / November 1999
589-652Number 11 / October 1999
529-587Number 10 / September 1999
439-528Numbers 8-9 / August 1999
379-438Number 7 / June 1999
321-377Number 6 / May 1999
257-320Number 5 / May 1999
121-256Numbers 3-4 / April 1999
61-120Number 2 / March 1999
1-60Number 1 / January 1999
Volume 124
643-700Number 12 / December 1998
585-641Number 11 / November 1998
527-583Number 10 / October 1998
471-525Number 9 / September 1998
409-469Number 8 / August 1998
353-408Number 7 / July 1998
291-351Number 6 / July 1998
231-290Number 5 / May 1998
131-230Numbers 3-4 / April 1998
65-130Number 2 / March 1998
1-64Number 1 / February 1998
Volume 123
581-680Numbers 11-12 / December 1997
531-579Number 10 / October 1997
467-530Number 9 / December 1997
413-466Number 8 / August 1997
363-412Number 7 / July 1997
301-362Number 6 / June 1997
243-299Number 5 / May 1997
189-242Number 4 / April 1997
133-187Number 3 / March 1997
71-132Number 2 / February 1997
1-70Number 1 / January 1997
Supplement 1 / January 1997
Scroll upScroll down
Archival Content
REFERENCES (17)EXPORT CITATIONABOUT
Abstract
Purpose
To evaluate clinical outcomes associated with single-session, whole-liver radioembolization with Yttrium-90 (90Y)-labeled resin microspheres in patients with nonresectable liver metastases from breast cancer that were refractory to other treatments.
Methods
A retrospective analysis of consecutive patients who were treated between January 2002 and October 2008 was performed. Fifty-eight patients with unresectable liver metastases from breast cancer who had a good performance status and a low burden of extrahepatic disease were eligible for RE. Patients had undergone polychemotherapy regimens including at least anthracyclines and taxanes, hormonal therapy, and trastuzumab were applicable.
Results
A median activity of 1.93 GBq of 90Y was delivered. Follow-up at a median of 4.2 months demonstrated complete response, partial response, stable disease, and progressive disease in 5, 52, 31, and 12 % of patients, respectively. With respect to tumor diameters, imaging revealed a maximum and minimum response of −57.6 to +25.8 %, respectively. The median overall survival was 12.3 months. The median survival of responders and nonresponders was 20.9 and 6.3 months, respectively, and the median survival of patients with and patients without extrahepatic disease was 8.3 and 16.2 months, respectively. Clinically significant toxicities with the appearance of increasing transaminase level, increasing bilirubin level, nausea and vomiting, gastric ulcers, and ascites.
Conclusions
Single-session, whole-liver 90Y radioembolization can be performed with an acceptable toxicity profile in patients with liver metastases from breast cancer.