Can Resistance to Trastuzumab Be Reversed by Endocrine Therapy?

[Hopeful]

Abstract:

http://www.abstracts2view.com/sabcs10/view.php?nu=SABCS10L_545

Poster:

http://www.abstracts2view.com/sabcs10/viewp.php?nu=P3-14-16

Hopeful

[Rich66]

Conclusion: Results of this proof-of-principle trial suggest that complete resistance to both AI and T can be overcome in a proportion of pts. by combined treatment of AI and T, as all pts. served as their own control. Our results appear promising for a new treatment strategy which offers a chemotherapy-free and well-tolerated option for at least a subset of the pts. with HR positive, HER-2 positive breast cancer. Further trials will need to corroborate this finding.
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