TCH or FEC?

[imatthew]

We have our first oncologist consultation tomorrow so I've been studying what I can tonight, based on my wife's diagnosis I'm assuming her oncologist will recommend either TCH or FEC (plus herceptin), but I haven't been able to find anything that would indicate why one or the other. Any assistance is appreciated.

Thank you.

[Laurel]

Matthew,

If you google ACTH (adriamycin, cytoxin, taxol, herceptin) vs TCH (taxol, carboplatin, herceptin) you will find a good bit of information. The long term studies are not in yet, but the stats thus far look fairly equal. FEC is similar to ACTH with the Epirubicin being a less cardiotoxic version of Adriamycin and the Cytoxin is the same. I do not know much about 5FU as it is not used for breast cancer much here in the States. I do know that it is not advisable for the Eprirubicin to be administered in conjunction with the Herceptin, sequentially is the way to go with Herceptin being given upon the completion of the Eprirubicin.

[caya]

Matthew,

I was given FEC x 3, then Taxotere x 3, then I had my Herceptin, every 3 weeks for a year. My onc. strongly recommended the Taxotere along with the FEC, said it was very good fighting Her2+ BC.
FEC is commonly used in Canada, England and other commonwealth countries.
TCH is a newer combo, I don't know if it is given in Canada yet, as I am over 3 years post chemo, and over 2 years post Herceptin.

all the best
caya

[Jackie07]

Hi,

I had FEC for my first diagnosis in 2003. I think FEC was used in place of AC because of my lower than normal heart function. When TCH became the standard, I had TCH in 2007 for the local regional recurrence.

Since Herceptin is 'the' cure for Her2 breast cancer, I think TCH should be the choice for your wife. There are studies showing each drug targets certain part of the cancer cell (skeleton, etc.) Maybe that's why the newer protocol uses both. If you look at other newly diagnosed, seems several of them are doing 4 AC (=FEC) and then TH, then Herceptin only.

[pradabagssale]

Ghosts, christmas tree (http://www.christmastreekingdom.com) pumpkins, luxury bags (http://www.saleluggageonline.com) angels, vibram fivefingers (http://www.vibramshoesonline.com) demons, christmas tree (http://www.christmastreeroom.com) vampires, christmas lights (http://www.maxchristmastree.com) witches, burberry sale (http://www.myburberryoutlet.com) bats, Christian Audigier (http://www.ed-hardy-store.com) werewolves, Damenstiefel (http://www.bootsyard.de) butterfly, ugg boots (http://www.bootszone.fr) cat demon, угги (http://www.uggbootsbar.ru) Bunny, Superman, cheap nike shox (http://www.cheap-nikeshox.com) doctors, police, pirate cheap ugg boots (http://www.uggwinterbootssale.com) ... ... just Santa Claus (http://www.xmastreeforsale.com) the uggs online (http://www.boots-outlet-store.us) names ugg boots on sale (http://www.ugg-snow-boots.net) to ugg boots sale (http://www.cheap-ugg-outlets.com) be damen stiefel (http://www.bootssky.de) composed sheepskin boots (http://www.boots-outlet-store.us) of ugg boots (http://www.cheapuggbootsonsale.net) numerous artificial christmas trees (http://www.christmastreespace.com) large, that christmas ornaments (http://www.christmastreeroom.com) is, these cheap ugg boots (http://www.ugg-boots-for-cheap.com) names coach outlet (http://www.usacoachoutletstore.com) it snow boots (http://www.uggoutletsshop.com) is christmas tree (http://www.xmastreeforsale.com) destined damen stiefel (http://www.bootsbar.de) to chaussures femmes (http://www.bootsmall.fr) this schuhe online (http://www.bootsyard.de) kind uggs (http://www.uggbootssky.ru) of thriller Ugg Australia (http://www.bootsyard.de) is sheepskin boots (http://www.ugg-winter-boots.net) certainly luggage online (http://www.saleluggageonline.com) large, christmas tree decorations (http://www.christmastreekingdom.com) science fiction, ugg boots (http://www.boots-outlet-store.us) some uggs (http://www.uggbootszone.ru) of ed hardy (http://www.ed-hardy-store.com) them coach handbags (http://www.usacoachoutletstore.com) are X-rated movie, not mens cufflinks (http://www.salecufflinks.com) necessarily coach purses (http://www.usacoachoutletstore.com) the ugg boots (http://www.uggsmall.ru) domestic snow boots (http://www.cheap-snow-boots.com) release, christmas tree outlet store (http://www.christmastreespace.com) not bape (http://www.discountbapeshoes.com) suitable угги (http://www.uggbootszone.ru) for children uggs sale (http://www.boots-online.us) to cheap uggs (http://www.uggbootssaleforcheap.com) seeGhosts, mbt (http://www.mbt-outlet-store.com) pumpkins, new balance outlet (http://www.salenewbalance.com) angels, demons, ugg outlet (http://www.winterbootsoutlet.com) vampires, ugg boots (http://www.cheap-uggboots-sale.org) witches, bats, Ugg Stiefel (http://www.bootsmall.de) werewolves, cufflinks (http://www.salecufflinks.com) butterfly, cat balenciaga handbags (http://www.balenciagabagsonline.com) demon, new balance shoes (http://www.salenewbalance.com) Bunny, winter boots (http://www.mycheapuggs.net) Superman, plush toys (http://www.nici2u.com) doctors, police, pirate ugg australia (http://www.uggsmall.ru) ... ugg boots (http://www.uggbootsshop.ru) ... christmas tree (http://www.christmastreesky.com) just vibram (http://www.vibramfivefingerss.org) the artificial christmas trees (http://www.christmastreesky.com) names snow boots (http://www.ugg-boots-for-cheap.com) to be cheap christmas trees (http://www.maxchristmastree.com) composed balenciaga bags (http://www.balenciagabagsonline.com) of ugg boots (http://www.boots-online.us) numerous large, discount snow boots (http://www.cheap-snow-boots.com) that discount ugg boots (http://www.discount-uggs-sale.com) is, nike shox (http://www.cheap-nikeshox.com) these christmas strees sale (http://www.christmastreespace.com) names uggs outlet (http://www.cheap-ugg-outlets.com) it is destined Ugg Boots (http://www.bootsyard.de) to Ugg Schuhe (http://www.bootssky.de) this kind Ugg Australia (http://www.bootsbar.de) of christmas tree (http://www.maxchristmastree.com) thriller is Ugg Schuhe (http://www.bootsmall.de) certainly Ugg boots (http://www.ugg-boots-for-cheap.com) large, iPhone cases (http://www.apple-accessories-online.com) science cheap uggs (http://www.boots4u.ca) fiction, Ugg Stiefel (http://www.bootsbar.de) some uggs (http://www.ugg-boots-for-cheap.com) of xmas tree (http://www.xmastreeoutlet.com) them nike basketball shoes (http://www.usabasketballshoes.com) are christmas tree (http://www.christmastreespace.com) X-rated ugg boots australia (http://www.bootsmall.fr) movie, iPhone accessories (http://www.apple-accessories-online.com) not ugg winter boots (http://www.ugg-winter-boots.net) necessarily ugg boots (http://www.ugg-winter-boots.net) the nici (http://www.nici2u.com) domestic new balance (http://www.salenewbalance.com) release, uggs on sale (http://www.uggoutletsshop.com) not winter boots (http://www.bootszone.fr) suitable for stiefel leder (http://www.bootsbar.de) children uggs sale (http://www.discount-uggs-sale.com) to winter boots (http://www.cheapuggbootsonsale.net) seeGhosts, pumpkins, cheap uggs (http://www.cheap-uggssale.com) angels, burberry online (http://www.myburberryoutlet.com) demons, vibram five fingers (http://www.vibramshoesonline.com) vampires, witches, Ugg Boots (http://www.bootsmall.de) bats, winter boots (http://www.ugg-boots-for-cheap.com) werewolves, luggage bags (http://www.saleluggageonline.com) butterfly, ugg australia (http://www.uggbootsshop.ru) cat ugg boots (http://www.boots4u.ca) demon, Bunny, uggs outlet (http://www.cheap-uggboots-sale.org) Superman, five finger shoes (http://www.vibramfivefingerss.org) doctors, police, artificial Xmas trees (http://www.cheapxmastree.com) pirate burberry outlet (http://www.myburberryoutlet.com) ... ... nike dunk (http://www.nike-dunks-outlet.com) just Ugg Boots (http://www.bootsbar.de) the names to cufflinks uk (http://www.salecufflinks.com) be ugg boots australia (http://www.bootsbar.fr) composed of bathing ape (http://www.discountbapeshoes.com) numerous large, Ugg Australia (http://www.bootssky.de) that basketball shoes outlet (http://www.usabasketballshoes.com) is, xmas tree (http://www.cheapxmastree.com) these christmas lights (http://www.xmastreeoutlet.com) names chaussures femmes (http://www.bootsbar.fr) it uggs on sale (http://www.uggbootssaleforcheap.com) is mbt shoes (http://www.mbt-outlet-store.com) destined uggs online (http://www.ugg-boots-for-cheap.com) to Ugg Boots (http://www.bootssky.de) this kind of thriller schuhe online (http://www.bootssky.de) is ugg boots (http://www.uggbootsbar.ru) certainly large, science ugg boots sale (http://www.cheap-uggssale.com) fiction, ugg boots (http://www.mycheapuggs.net) some xmas tree (http://www.topxmastree.com) of them nike air force 1 (http://www.air-force-one.com) are ugg boots sale (http://www.uggwinterbootssale.com) X-rated ugg boots (http://www.cheapuggsoutlet.org) movie, luggage (http://www.saleluggageonline.com) not vibram five fingers (http://www.vibramfivefingerss.org) necessarily the nike sb shoes (http://www.nike-dunks-outlet.com) domestic coach usa (http://www.usacoachoutletstore.com) release, christmas ornaments (http://www.maxchristmastree.com) not ugg australia (http://www.uggbootssky.ru) suitable ugg outlet (http://www.cheapuggsoutlet.org) for cufflinks for men (http://www.salecufflinks.com) children Nike air force (http://www.air-force-one.com) to snow boots (http://www.ugg-snow-boots.net) see

[Chelee]

What seems to be used most often...or known as the standard of care is "ACTH" as Laurel mentioned, & TCH. If you have heard of Dr. Slamon out at UCLA...he is the one that made Herceptin. His clinic will only treat you with TCH. The studies between ACTH and TCH showed very little difference. The main difference is lower risk of heart damage with TCH. So I'm pretty sure your wife will be offered one of those two choices. (It's so nice of you to research online and help your wife out...she is so blessed to have a wonderful husband to support her through this.) You both take care and keep us updated. We are here for you.

Chelee

[imatthew]

thanks to everyone for the information. Our oncologist has recommended 6 courses of Taxotere / Carboplatin, and a year of Herceptin every three weeks. She will receive a port next week and start treatment the week after that. From everything I've read that seems like a pretty common course of treatment for her diagnosis.

[Laurel]

All the very best, Matthew. Stay in touch and let us know how you two are doing.