Peach and Plum extracts may kill breast cancer cells in future

[hutchibk]

http://aglifesciences.tamu.edu/news/6-2010-peaches.php

Breast cancer cells - even the most aggressive type - died after treatments with peach and plum extracts in lab tests at Texas AgriLife Research recently, and scientists say the results are deliciously promising. Not only did the cancerous cells keel over, but the normal cells were not harmed in the process.

[Laurel]

I have been taking Plum Extract for months now. Keeping fingers crossed.

[Ellie F]

Going to get some right NOW!!

Ellie

[Ellie F]

Laurel
Which type of plum extract do you take?? Tried to order some on the net but there are loads of different ones!!

Ellie (again)

[Rich66]

Here is the study.


J Agric Food Chem. (javascript:AL_get(this,%20'jour',%20'J%20Agric%20 Food%20Chem.');) 2009 Jun 24;57(12):5219-26.
Identifying peach and plum polyphenols with chemopreventive potential against estrogen-independent breast cancer cells.

Noratto G (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Noratto%20G%22%5BAuthor%5D), Porter W (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Porter%20W%22%5BAuthor%5D), Byrne D (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Byrne%20D%22%5BAuthor%5D), Cisneros-Zevallos L (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Cisneros-Zevallos%20L%22%5BAuthor%5D).
Department of Horticultural Sciences and Vegetable and Fruit Improvement Center, Texas A&M University, College Station, Texas 77843, USA.
Abstract

Our objective was to evaluate the cancer suppression activity of extracts from a commercial variety of yellow-fleshed peach 'Rich Lady' (RL) and a red-fleshed plum 'Black Splendor' (BS) and identify the phenolic fractions that may possess potential as chemopreventive and/or chemotherapeutic natural compounds. The peach RL extract effectively inhibited the proliferation of the estrogen-independent MDA-MB-435 breast cancer cell line. The concentration to inhibit 50% of cell proliferation (IC(50)) was approximately 42 mg/L for this cell line compared to an IC(50) of approximately 130 and approximately 515 mg/L for the noncancerous breast cell line MCF-10A and the estrogen-dependent breast cancer cell line MCF-7, respectively. Similarly, BS extracts showed greater effects on MDA-MB-435 cells as compared to the other breast cancer or the normal breast cell lines. In general, BS extracts were less effective than RL extracts. Within all RL and BS fractions, fraction 3 (F3, flavonoids) and fraction 4 (F4, procyanidins) were more potent than fraction 1 (F1, phenolic acids) and fraction 2 (F2, anthocyanins) against the three cell lines. The order of potency of RL fractions against MDA-MB-435 was F(3) approximately F(4) > F(1) > F(2). The antiproliferative activity of pure compounds identified in F(3) and F(1) confirmed that quercetin 3beta-glucoside is the bioactive compound in F(3), with the same level of toxicity on the estrogen-independent MDA-MB-435 breast cancer and breast epithelial MCF-10A cells (IC(50) = 1.9 +/- 0.2 and 1.8 +/- 0.3, respectively). However, we confirmed that phenolic acids present in F(1): chlorogenic and neo-chlorogenic acids have potential as chemopreventive dietary compounds because of the relatively high growth inhibition exerted on the estrogen-independent MDA-MB-435 breast cancer cell line and low toxicity exerted in the normal MCF-10A cells.

PMID: 19530711 [PubMed - indexed for MEDLINE]

Note that it mentions a form of Quercetin in there.
I will say that I was viewing Quercetin favorably until I encountered various studies suggesting it can be estrogenic. In other cases, like apigenin, the helpful component can be estrogenic at one dose and estrogen inhibiting at another. It seems the supplement side is much more complicated in ER+ situations.

[karen z]

Brenda,
thanks for posting.

[CourtneyL]

This is right in line with what Dr. David Sevan Schrieber talks about in his book - Anticancer (a MUST read). (Thanks for recommending it, EllieF!). He says "stone fruits" such as peaches and plums have incredible anti-cancer properties. I've been eating as much as I can lately since they are in season right now where I live (California). Happy stone fruit eating! Maybe I'll pick up some extract too.

Thanks for posting, Brenda! I love the idea of eating my way healthy.

[Laurel]

Ellie,

I take Kyoto brand Mumefural Concentrate (100% Natural Japanese Plum Extract). I order mine from www.SwansonsVitamins.com (http://www.SwansonsVitamins.com).

L.

[Ellie F]

Thanks Laurel
I seem to be importing most of my supplements from the States!! Lets hope the post office don't get suspicious that I'm a drug dealer!!

Ellie

[Carol.hope]

This is exciting news! To be able to kill the cancer cells and not the healthy cells - what a great idea! Thanks for the info!