Inhibition of phosphatidylcholine-specific phospholipase C depletes her2 receptors

[Lani]

via multiple mechanisms

her2+ breast cancer cells have 2 million her2 receptors per cell, whereas normal cells have only 2 or 3, according to Dr Slamon

seems to be more effective vs. ER- than ER+ her2+ cell lines(SkBr3 vs BT474)

question is how safe it might be, but in at least one study in mice it seemed not to affect them adversely in any measurable way

Inhibition of phosphatidylcholine-specific phospholipase C downregulates HER2 overexpression on plasma membrane of breast cancer cells

http://breast-cancer-research.com/content/pdf/bcr2575.pdf

[Ellie F]

There seems to be a flood of promising research at present even though often it is still in mice! Lets hope this translates to a cure soon.Once again thanks lani.

ellie