Cell Study Finds Receptor Can Fight Tamoxifen-resistant Breast Cancer Cells

[News]

A receptor that is present in the nucleus of cells can, when activated, slow the growth of tamoxifen-resistant breast cancer cells, a new study found. The study built on the recent discovery that farnesoid X receptor (FXR) a nuclear receptor found mainly in the liver is found in breast cancer tissue...

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[1rarebird]

I think this could turn out to have important significance for us. The researcher states:

'Why would FXR work better against MCF-7TR, the tamoxifen-resistant cells? Part of the explanation may be that MCF-7TR relies more on HER2, and FXR targets HER2, Giordano said. That would make the tamoxifen-resistant cancer cells more vulnerable to activated FXR.'

Perhaps Her2+ will have even more impact from this finding if further studies continue to show the effect, particularly for triple positive BC cancer.

(Disclosure: I always pay attention when Professor Giordano is speaking. She is one of the few researchers advocating for male breast cancer patients these days.)