HER2 Serum Test Proves To Be Effective

[Joe]

This was posted in a different thread, but I believe it is important:


Citation: European Journal of Cancer Supplements Volume 8, No.3, March 2010, page 115

H. Makino1, K. Kuninaka1, C. Yoshida1, H. Hashidate2, M. Siotani3

1Niigata City General Hospital, Breast Oncology, Niigata, Japan
2Niigata City General Hospital, Pathology, Niigata, Japan
3Niigata City General Hospital, Radiology, Niigata, Japan

Background: Tumor markers can be an easier modality to detect cancer metastasis compared with diagnostic imaging, and its decrease or increase is often correlated with effectiveness of treatment.

Patients and Methods: Serum human epidermal growth factor receptor 2 extracellular domain (HER2-ECD) levels were reviewed in 56 breast cancer patients with metastasis and 21 patients who underwent preoperative systemic therapy (19: chemotherapy, 2: endocrine therapy). Patients were stratified into 2 groups, those with HER2-positive (group I) and negative (group II) breast cancer.

Results: In patients with metastatic disease, median serum HER2-ECD level was 14.6 ng/ml (group I) vs 12.9 ng/ml (group II, p = 0.14). furthermore, HER2-ECD levels were assessed in 17 patients at the detection of metastasis. In those, HER2-ECD was significantly higher in patients of group I (median: 17.2 ng/ml) than group II (12.2 ng/ml, p = 0.03), and proportion of patients with raised HER2-ECD (>15.3 ng/ml) was 75% (group I) vs 23% (group II, P = 0.099). In patients who undergoing preoperative treatment, median HER2-ECD level was 12.8 ng/ml (group I) vs 9.5 ng/ml (group II, p = 0.28). Proportion of patients with raised HER2-ECD was significantly higher in group I (60%) than in group II (0%, p = 0.008). In those patients, HER2-ECD levels decreased following chemotherapy, and were observed to be less than 15.3 ng/ml in patients who achieved pathological complete response. In 11 patients (85.7%) out of 14 who were evaluated both HER2-ECD levels and imaging diagnosis following systemic therapy, HER2-ECD was successfully associated with tumor response.

Conclusion: Serum HER2-ECD levels were observed to be raised in 75% of HER2-positive breast cancer patients at the time of detection of metastases, and well associated with tumor response in 85.7% of patients.


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Regards
Joe

[Joe]

EBCC: HER2 Levels May Predict Breast Cancer Response


By Charles Bankhead, Staff Writer, MedPage Today
Published: March 25, 2010
Reviewed by Zalman S. Agus, MD (http://her2support.org/reviewer.cfm?reviewerid=30); Emeritus Professor
University of Pennsylvania School of Medicine and

Dorothy Caputo, MA, RN, BC-ADM, CDE, Nurse Planner

BARCELONA -- Monitoring HER2 levels during neoadjuvant breast cancer therapy may improve early identification of patients likely to benefit from trastuzumab (Herceptin), a prospective clinical trial suggests.

Elevated baseline levels of HER2 and a decline of at least 20% during treatment significantly increased the likelihood of pathologic complete response. In multivariate analysis, the 20% decline in HER2 levels remain statistically significant.
"Results of this study demonstrate that prechemotherapy serum HER2 levels as well as a decrease in serum levels to be a significant predictor of response to neoadjuvant chemotherapy for breast cancer," Isabell Witzel, MD, of the Medical University of Hamburg-Eppendorf in Hamburg, Germany, reported here at the European Breast Cancer Conference.
"Monitoring serum HER2 levels in the presence of trastuzumab treatment might be a promising adjunct to clinical evaluation during neoadjuvant chemotherapy in HER2-positive patients."
The neoadjuvant setting offers an opportunity to optimize treatment strategies for patients with nonmetastatic breast cancer. In patients with HER2-positive breast cancer, the extracellular domain of HER2 is shed into the serum, creating potential for a biological role of HER2 during treatment with trastuzumab, Witzel said.
To examine the association between serum HER2 levels and pathologic response, investigators used a commercially available assay to measure HER2 levels before and after neoadjuvant therapy in 90 patients with HER2-positive beast tumors and 85 patients with HER2-negative tumors. All patients with HER2-positive tumors received trastuzumab in addition to chemotherapy.
Pathologic complete response was defined as no microscopic evidence of invasive residual tumor cells in all resected specimens of the breast and lymph nodes. Neoadjuvant therapy led to pathologic complete response in 44 (49%) of HER2-positive patients compared with 12 (14%) HER2-negative patients (P<0.001).
Pretreatment median serum HER2 values were 7.7 ng/mL in the HER2-negative patients and 14.9 ng/mL in the HER2-positive group.
Receiver operating characteristic curve analysis identified 10 ng/mL as the optimal cutpoint for discriminating between HER2-positive and negative tumors, resulting in a sensitivity of 72%, specificity of 85%, positive predictive value of 85%, and negative predictive value of 73%.
Comparing baseline HER2 values and pathologic complete response, the investigators found that a baseline value >15 ng/mL was significantly associated with pathologic complete response (P=0.045). An even stronger association emerged from an analysis of the decline in serum HER2 levels in response to treatment (P=0.02).
In multivariate analysis, a decrease of >20% tripled the likelihood of pathologic complete response (OR 3.2, 95% CI 1.13 to 9.55, P=0.029).


Entire Paper (http://her2support.org/pdf/serumher2a.pdf)

Regards
Joe

[Jean]

Joe,
Thank you for posting this important information.
Why is it that dr. are still not addressing this useful tool
in patient maintenance. Especailly in early stagers with follow up visits.

Jean

[Joe]

Jean,
These studies were just presented this week. If your oncologist is still resistant..print out the studies and give them to your doctor.

For information: The test only costs $300 and most insurance companies will pay.

Regards
Joe

[Jean]

Joe,
thanks for your speedy reply....will do.
Timing in our lives is everything.
Thinking of you, Christine and the girls during this special week. We must take the time to remember how thankful we are to have the special people in our lives
who make the world a better place for us.

Jean

[Rich66]

As I looked back on this issue, momentum roughly a year ago was away from the test. Now it's moving towards embracing it. From what I can tell, there is more support in monitoring direction as opposed to the importance of starting levels. Which is..kinda like tumor markers. Although..the one study using Lapatinib claimed no correlation to treatment.

I have compiled what I could find on Serum HER and EGFR testing and put it here:
http://her2support.org/vbulletin/showthread.php?p=225648#post2256488