thought you would like to read this--REAL HOPE OF A CURE

[Lani]

OPEN ACCESS: EDITORIAL: Whither HER2-Related Therapeutics?
[Journal of Clinical Oncology]
It is apparent that increasing knowledge of molecular signaling pathways regarding HER2/Neu amplified breast cancer biology has paved the way toward novel, innovative targeted combination therapeutics. The multiplicity of potential targets along the PI3K-AKT-mTOR or HER2-GRB7-RAC1 pathway requires careful preclinical evaluation to ensure optimal activity, minimal toxicity, and lack of resistance. The sheer multiplicity of approaches outlined above will need to correspond to measurements of driving molecular signaling pathways on an individual patient basis. In the meantime, the patient faces a panoply of HER2-directed therapies and state-of-the-art clinical trials, yielding better responses, survival, quality of life, and real hope of a cure.

[Chelee]

Lani,
Thanks for sharing this. It's very encouraging.

Chelee

[schoolteacher]

Thanks for the article, Lani. Hope a cure is found soon.

Amelia

[Ellie F]

Yeah!! I remember reading that an American breast onc professor last year said that he believed in 5 years no women would need to die from her 2 bc. There may not be a cure but that they would have the ability to control it.
Praying that 5 years becomes this year.
Ellie

[YNieves]

Amen to that!

[1rarebird]

Yes, there is great promise for curing this disease. We all are praying that it comes sooner than later. On the other hand, the "panoply of HER2-directed therapies" now faced by the patient is almost too much to bear at times as we try to sort them all out. Those of us who have oncologists and groups like this one that can intelligently help guide us with the choices are the fortunate ones.

[Rich66]

Can you update with a link? Sounds interesting.

I just hope they don't overlook potential pan-cancer (http://her2support.org/vbulletin/showthread.php?p=222554#post222554) achille's heels while swimming in the "panoply".

[CourtneyL]

Thank you, Lani!

I have been following the Herceptin/PI3 kinase inhibitor combination for a while. Check out this poster from a company named ARRAY which makes a PI3 kinase inhibitor called ARRY 380. It shows that, in lab mice, this combo had a 100% cure rate!

http://www.arraybiopharma.com/_documents/Publication/PubAttachment337.pdf

ARRY 380 is currently in clinical trial as a single agent at M.D. Anderson.

However, for those of you interested in a clinical trial combining BOTH a version of Herceptin (T-DM1) and a PI3 kinase inhibitor, Dana Farber currently has one in a Phase I trial. I met with Dr. Ian Krop in December to discuss joining but he suggested I wait until it reaches Phase II as it is coming to UCSF - where I live. Here is a link to the Dana Farber trial:

http://clinicaltrials.gov/ct2/show/NCT00928330?term=t-dm1&recr=Open&rank=6

[Jean]

Lani and Courtney....
A big thank you...

These are important evidence based information and demonstrate the positive research that is being done now. We all are praying for a break through.

[Chelee]

Rich, Hope this link is what your looking for?

http://jco.ascopubs.org/cgi/content/full/28/7/1091

Chelee

[Rich66]

Thanks......adding dots to make post long enough....

[Laurel]

You guys have me so excited! How am I going to sleep tonight? Courtney, that is so great! Let us know if you do enter the trial. Lani, fantastic news for all of us. Thanks!

Hey, here's a thought: if they do actually find a Her-2 cure, let's all meet at an appointed hour in an appointed place somewhere in the word for a drink and chocolate! Hey, we can do both in a chocolate martini! Ha! There's the ticket!

Sheesh....I'm giddy!

[Julie2]

Courtney,

Any idea when is the trial coming to UCSF? I goto UCSF too.

thanks,
Julie

[Ellie F]

My onc has been going on about P13 inhibition each time I meet him. He is convinced that harnessing this would result in a quantum shift in treatment!!
So girls i am saving up my money so I can come and see you all if a trial becomes available!! Might even manage a chocolate with Laurel.

Hanging in there for the CURE

Ellie

[Rich66]

Ellie,
While pharma works out the patents and trials, consider Honokiol or IP-6.

[Julie2]

Rich,

Do you know where to get Honokiol or IP-6?

Thanks,
Julie

[Rich66]

Some honokiol(magnolia) sources on Google HERE (http://www.google.com/search?q=buy+magnolia+extract&ie=utf-8&oe=utf-8&aq=t&rls=org.mozilla:en-US:official&client=firefox-a)
Combo with Honokiol HERE (http://www.naturalhealthyconcepts.com/inflam-away-80-p-new-products.html)

IP-6 HERE (http://www.raysahelian.com/ip-6.html)

I have seen a form of IP-6 in Walgreens.

Seems like liposomal versions of supplements are preferrable when available.

[CourtneyL]

Laurel - I will be there to celebrate the cure with you - chocolate martini in hand! It is coming, I KNOW IT!

Julie - I asked Melisko when the trial was coming to UC and she said "a few months" so that could mean 2 or 6, I don't really know. She was going to ask Rugo. I'd ask them about it the next time you are there. Let me know what they say. I don't actually go to UC for treatment but I occasionally consult with Melisko for second opinions.

[StephN]

IP - 6 - I used to get a good one at my local GNC store. I see that there are a few different trustworthy companies offering it at my local supplements specialty store. I don't take it now.

Personally, I do not get any supplements at Walgreens. Too many formulations from who knows where. I will pay a little more for best quality after what I have been through!

Looks like some exciting trials not far down the road. Please, girls, keep us posted.

[Unregistered]

Sorry... any news about that PI3 kinase inhibitor?

[Pam P]

Laurel - I'm for meeting for a chocolat martini -- let's make the meeting place somewhere wonderful and exotic!

Lani, Rich, Courtney.... Thanks once again for your steadfast research and information sharing. I appreciate all you do. This is VERy exciting. Pam

[Ellie F]

Also wondering if there is any news? I know there are currently trials of mtor inhibitors in the pipeline.


Ellie

[Unregistered]

Yes I found 1 clinical trial in USA and Canada http://www.cancer.gov/search/ViewClinicalTrials.aspx?cdrid=594061&version=HealthProfessional&protocolsearchid=8658921

[Unregistered]

And this http://www.clinicaltrials.gov/ct2/results?term=PI3+kinase+inhibitor
I don't understand are those different inhibitors or not?

[KDR]

Where is the link? I'm so excited to read it! Lani, do you have it? Courtney, you insipire me to no end, girl!
Woohoo, Karen

[Jackie07]

Karen,

Scroll up the screen and you will find two links posted by 'unregistered' (just before yours.)

[Joan M]

Lani,

Great news. It really gives us hope.

Joan

[KDR]

I am not scientifically-inclined and the link posted looked like material I, for one, cannot understand. I do have a feeling about this, though.

[Jackie07]

The researchers have identifies two new 'pathways' and are conducting clinical trials.

Did you read the link Chelee posted of the article that Lani mentioned?

http://jco.ascopubs.org/content/28/7/1091.full

[DiDi70]

Thank you so much for this valuable information. Here in Canada we seem to have very few trials and certainly not even TDM1. Without you, I would be in the dark about what is available to me just in a few hours drive across the border.

There is HOPE.

Time to celebrate!

[Trish]

Thanks Lani et al ..I love reading about real hopes for a cure. Good to hear from you Courtney. I was wondering how you were doing.
Trish

[suzan w]

thanks lani. I read it, with a dictionary, but the last line is what I hang on to!!! Real Hope of a CURE!!!

[A. L. Pendley]

Hello CourtneyL and others,
I was looking for any posts on Arry 380 and found Courtney's. I'm in the 5th week of the clinical trial of this new drug (given with Herceptin too). I'll be finding out next week if there's been good results - hope so! I go to Dana Farber Cancer Institute in Boston, MA (I live in Colorado and fly there for treatment). I'm starting to get a handle on side effects (diarrhea, fatigue, digestion issues) ... not too bad. Lost a lot of weight from diarrhea, but learning how to better take Lomotil. I am the 3rd participant (was a total of 3 last visit - ha) and I'm hoping for more participants so I can someday see how others are doing. Would love to see more comments on this trial. Cheers to my cancer buddies, Ann L

['lizbeth]

I think I saw it on the presenter schedule at the San Antonio Breast Cancer Symposium next week.

[tricia keegan]

Laurel I'm with you on that drink and choclolate!:)

Lani thank you for the info!