Herceptin resistant

[Janet Taylor]

I have had 4 reoccurences of metastatic breast cancer in my lungs within the last 4 years despite being on Herceptin almost 4 years straight. I did about 8 months of Tykerb and Xeloda in the middle of the 4 years of Herceptin.

I am looking for a good next step. I am looking for a clinical trial in the Ohio area. I want a drug that will be effective and not interrupt my quality of life.

Does anyone have any advice? I have refused to have a 4th lung surgery.

[Hopeful]

Janet,

Here is a link to an article that is posted in the Breast Cancer Newsfeed forum today: http://www.medicalnewstoday.com/articles/166809.php

I hope it helps. Best of luck to you with a new treatment plan.

Hopeful

[julierene]

I'm sorta in your shoes, if you see my signature. I have heard great things about Avastin and Ixempra. The trick is getting insurance to approve the two together since they like all 3 taxanes to be used first.

[julierene]

http://www.clinicaltrials.gov/ct2/show/NCT00570921?term=Everolimus&recr=Open&rank=32


http://www.clinicaltrials.gov/ct2/show/study/NCT00426556?term=Everolimus&recr=Open&rank=46&show_locs=Y#locn
(in Illinois?)

RAD001 = Everolimus - you can search those separately and also look for solid tumors (not just breast cancer)

[schoonder]

Focus of T-DM1 trials is to overcome poor response to or acquired resistance to herceptin in her2+ patients.
Here's link to couple of trial possibilities:

T-DM1 & Pertuzumab trial In Columbus, Ohio
http://www.clinicaltrials.gov/ct2/show/NCT00943670?term=t-dm1&rank=2 (http://www.clinicaltrials.gov/ct2/show/NCT00943670?term=t-dm1&rank=2)

T-DM1 combo trial conducted in neighboring states.
http://www.clinicaltrials.gov/ct2/show/NCT00928330?term=t-dm1&rank=7 (http://www.clinicaltrials.gov/ct2/show/NCT00928330?term=t-dm1&rank=7)

further away, but another promising combo trial
http://www.clinicaltrials.gov/ct2/show/NCT00951665?term=t-dm1&rank=6 (http://www.clinicaltrials.gov/ct2/show/NCT00951665?term=t-dm1&rank=6)
one more in Indiana
http://www.clinicaltrials.gov/ct2/show/NCT00875979?term=t-dm1&rank=5 (http://www.clinicaltrials.gov/ct2/show/NCT00875979?term=t-dm1&rank=5)