PARP inhibitor trial

[Joan M]

Just a thought.

I'm borderline HER2+, and I often wonder whether that almost makes me triple-negative bc and whether I might benefit from TNBC therapies.

My lung met was HER2+, but my brain MET was HER2-.

PARP inhibitor trials for TNBC have been in the news lately showing phase II BSI-201 trial results and a new BSI-201 phase III trial, as well as a TNBC phase II trail results of a related PARP inhibitor drug, olaparib, for woman who are BRCA1 or BRCA2 positive.

http://www.clinicaltrials.gov/ct2/show/NCT00938652?term=bsi-201&rank=7

I was told that I was borderline HER2+, and generally that means treating for HER2+, just to be on the safe side.

Joan

[Ceesun]

Joan, I have seen several articles on treating triple negative both in Cure Magazine and another called Women. If you would like copies, I will gladly mail to you. Ceesun Stay Well.

[Joan M]

Ceesun,

Thanks for offering the articles but I've read about triple negative cancer in a few places. Perhaps also in Cure, too. It's been in the news lately. I can probably check further into it on the Internet, and when I see my "other" oncologist soon, who specializes in bc, I'm going to ask him. I believe my HER2 status was very close to the cut-off point, or perhaps right on that point, as noted in the trial inclusion criteria.

Joan

[Faith in Him]

I am trying to explore this also since my recurrence was triple negative. I am having my mastecomy tissue retested and will know more in a few weeks. I also need to get the BRAC testing done.

I know of a lady with her2 and BRAC who is doing well on this trial.

[Joan M]

Tonya,

When I find out more from the onc I'll let you know.

TNBC is a bit confusing to me. I think it might be a "biological subset" of its own and therefore not apply at all (that is, either you have it or you don't). But sometimes therapies can work anyway. I intend to ask the onc.

Joan