Lani
03-17-2009, 05:32 AM
be screen for hypothyroidism?
1: Int J Radiat Oncol Biol Phys. 2009 Mar 13. [Epub ahead of print]
Thyroid Function in Women after Multimodal Treatment for Breast Cancer Stage II/III: Comparison with Controls from a Population Sample.
Reinertsen KV, Cvancarova M, Wist E, Bjøro T, Dahl AA, Danielsen T, Fosså SD.
Department of Clinical Cancer Research, The Norwegian Radium Hospital, Rikshospitalet University Hospital, 0310 Oslo; Faculty Division the Norwegian Radium Hospital, University of Oslo, O316 Oslo, Norway; The Cancer Center, Ullevål University Hospital, University of Oslo, O316 Oslo, Norway.
PURPOSE: A possible association between thyroid diseases (TD) and breast cancer (BC) has been debated. We examined prevalence and development of TD in women after multimodal treatment for Stage II/III BC compared with women from a general population. Secondarily, we explored the impact of two different radiotherapy (RT) techniques (standardized field arrangements vs. computed tomography [CT]-based dose planning) on TD in BC patients examined 35-120 months after primary BC treatment. METHODS AND MATERIALS: A total of 403 BC patients completed a questionnaire about TD and had blood samples taken for analyses of thyroid function. All had undergone postoperative RT with or without (2%) adjuvant systemic treatment. The results in the BC patients were compared with a cancer-free, age-matched control group from a general population (CGr). RESULTS: There was higher prevalence of self-reported hypothyroidism in the BC patients as compared with the CGr (18% vs. 6%, p < 0.001). The raised prevalence was predominantly due to a substantial increase in the development of hypothyroidism after BC diagnosis, whereas the prevalence of hypothyroidism before BC diagnosis was similar to that observed in the CGr. Patients treated with CT-based RT showed a trend for increased post-BC development of hypothyroidism as compared with those treated with standardized field arrangements (p = 0.08). CONCLUSIONS: Hypothyroidism is significantly increased in women after multimodal treatment for Stage II/III BC. Radiation to the thyroid gland may be a contributing factor. BC patients should be routinely screened for hypothyroidism.
PMID: 19286332
1: Int J Radiat Oncol Biol Phys. 2009 Mar 13. [Epub ahead of print]
Thyroid Function in Women after Multimodal Treatment for Breast Cancer Stage II/III: Comparison with Controls from a Population Sample.
Reinertsen KV, Cvancarova M, Wist E, Bjøro T, Dahl AA, Danielsen T, Fosså SD.
Department of Clinical Cancer Research, The Norwegian Radium Hospital, Rikshospitalet University Hospital, 0310 Oslo; Faculty Division the Norwegian Radium Hospital, University of Oslo, O316 Oslo, Norway; The Cancer Center, Ullevål University Hospital, University of Oslo, O316 Oslo, Norway.
PURPOSE: A possible association between thyroid diseases (TD) and breast cancer (BC) has been debated. We examined prevalence and development of TD in women after multimodal treatment for Stage II/III BC compared with women from a general population. Secondarily, we explored the impact of two different radiotherapy (RT) techniques (standardized field arrangements vs. computed tomography [CT]-based dose planning) on TD in BC patients examined 35-120 months after primary BC treatment. METHODS AND MATERIALS: A total of 403 BC patients completed a questionnaire about TD and had blood samples taken for analyses of thyroid function. All had undergone postoperative RT with or without (2%) adjuvant systemic treatment. The results in the BC patients were compared with a cancer-free, age-matched control group from a general population (CGr). RESULTS: There was higher prevalence of self-reported hypothyroidism in the BC patients as compared with the CGr (18% vs. 6%, p < 0.001). The raised prevalence was predominantly due to a substantial increase in the development of hypothyroidism after BC diagnosis, whereas the prevalence of hypothyroidism before BC diagnosis was similar to that observed in the CGr. Patients treated with CT-based RT showed a trend for increased post-BC development of hypothyroidism as compared with those treated with standardized field arrangements (p = 0.08). CONCLUSIONS: Hypothyroidism is significantly increased in women after multimodal treatment for Stage II/III BC. Radiation to the thyroid gland may be a contributing factor. BC patients should be routinely screened for hypothyroidism.
PMID: 19286332