Lani
01-16-2009, 08:59 AM
breast cancer
the following article is open access (free to all)
just go to google, type in entrez pubmed and type the PMID number below into the address bar
BMC Cancer. 2009 Jan 14;9(1):19. [Epub ahead of print]
Freund's vaccine adjuvant promotes Her2/Neu breast cancer.
Cotroneo MS, Haag JD, Stapel NR, Waller JL, Woditschka S, Gould MN.
ABSTRACT: BACKGROUND: Inflammation has been linked to the etiology of many organ-specific cancers. Indirect evidence suggests a possible role for inflammation in breast cancer. We investigated whether the systemic inflammation induced by Freund's adjuvant (FA) promotes mammary carcinogenesis in a rat model in which cancer is induced by the neu oncogene. METHODS: The effects of FA on hyperplastic mammary lesions and mammary carcinomas were determined in a neu-induced rat model. The inflammatory response to FA treatment was gauged by measuring acute phase serum heptaglobin. In addition, changes in cell proliferation and apoptosis following FA treatment were assessed. RESULTS: Rats receiving FA developed twice the number of mammary carcinomas as controls. Systemic inflammation following FA treatment is chronic, as shown by a doubling of the levels of the serum biomarker, haptoglobin, 15 days following initial treatment. We also show that this systemic inflammation is associated with the increased growth of hyperplastic mammary lesions. This increased growth results from a higher rate of cellular proliferation in the absence of changes in apoptosis. CONCLUSIONS: Our data suggests that systemic inflammation induced by Freund's adjuvant promotes mammary carcinogenesis. It will be important to determine whether adjuvants currently used in human vaccines also promote breast cancer.
PMID: 19144184
the following article is open access (free to all)
just go to google, type in entrez pubmed and type the PMID number below into the address bar
BMC Cancer. 2009 Jan 14;9(1):19. [Epub ahead of print]
Freund's vaccine adjuvant promotes Her2/Neu breast cancer.
Cotroneo MS, Haag JD, Stapel NR, Waller JL, Woditschka S, Gould MN.
ABSTRACT: BACKGROUND: Inflammation has been linked to the etiology of many organ-specific cancers. Indirect evidence suggests a possible role for inflammation in breast cancer. We investigated whether the systemic inflammation induced by Freund's adjuvant (FA) promotes mammary carcinogenesis in a rat model in which cancer is induced by the neu oncogene. METHODS: The effects of FA on hyperplastic mammary lesions and mammary carcinomas were determined in a neu-induced rat model. The inflammatory response to FA treatment was gauged by measuring acute phase serum heptaglobin. In addition, changes in cell proliferation and apoptosis following FA treatment were assessed. RESULTS: Rats receiving FA developed twice the number of mammary carcinomas as controls. Systemic inflammation following FA treatment is chronic, as shown by a doubling of the levels of the serum biomarker, haptoglobin, 15 days following initial treatment. We also show that this systemic inflammation is associated with the increased growth of hyperplastic mammary lesions. This increased growth results from a higher rate of cellular proliferation in the absence of changes in apoptosis. CONCLUSIONS: Our data suggests that systemic inflammation induced by Freund's adjuvant promotes mammary carcinogenesis. It will be important to determine whether adjuvants currently used in human vaccines also promote breast cancer.
PMID: 19144184