Soccermom2006
09-12-2008, 10:19 AM
"The Bottom Line: Do Not Administer Any SSRI With Tamoxifen
The future is exciting with the possibility of developing truly customized, 100%-effective therapies for our patients. For the present, however, besides entering our patients onto well-designed clinical trials asking important questions, we must not encumber our currently available therapies with combinations of drugs that effectively make them a placebo. The bottom line is this: Do not administer any SSRIs (fluoxetine [Eli Lilly and Company, Indianapolis, IN], paroxetine [Paxil, GlaxoSmithKline, Pittsburgh, PA], sertraline [Zoloft, Pfizer, New York, NY], citalopam [Celexa, Forest Laboratories, Inc., New York, NY], or escitalopam [Lexapro, Forest Laboratories, Inc.]) concurrently with tamoxifen. When in doubt, check it out. Sources are listed in Table 3 (http://www.jopasco.org/cgi/content/full/1/4/155#T3). However, because this interaction is so recently documented, it is not yet included in many of the standard references. Be the first to tell your colleagues. "
http://www.jopasco.org/cgi/content/full/1/4/155 (2005)
http://jop.ascopubs.org/cgi/content/full/2/2/100 more recent (2006)
Thought that this might be of interest...
Marcia
The future is exciting with the possibility of developing truly customized, 100%-effective therapies for our patients. For the present, however, besides entering our patients onto well-designed clinical trials asking important questions, we must not encumber our currently available therapies with combinations of drugs that effectively make them a placebo. The bottom line is this: Do not administer any SSRIs (fluoxetine [Eli Lilly and Company, Indianapolis, IN], paroxetine [Paxil, GlaxoSmithKline, Pittsburgh, PA], sertraline [Zoloft, Pfizer, New York, NY], citalopam [Celexa, Forest Laboratories, Inc., New York, NY], or escitalopam [Lexapro, Forest Laboratories, Inc.]) concurrently with tamoxifen. When in doubt, check it out. Sources are listed in Table 3 (http://www.jopasco.org/cgi/content/full/1/4/155#T3). However, because this interaction is so recently documented, it is not yet included in many of the standard references. Be the first to tell your colleagues. "
http://www.jopasco.org/cgi/content/full/1/4/155 (2005)
http://jop.ascopubs.org/cgi/content/full/2/2/100 more recent (2006)
Thought that this might be of interest...
Marcia