MCC-DM-1 trial closed

[Joan M]

Just to let you know, the MCC-DM1 trial is closed at Sloan-Kettering, according to the office of the trial study doctor, Dr. Modi.

So that's one less option I have for treating my lung nodule.

I'm going to follow up because I think that the trial involves recruiting patients in waves and the trial may open and close.

Barbara H told me that when she first tried to get into the trial in her area it was closed and then reopened a few months later and she was able to enroll.

[Julie2]

Joan,

One of our memebrs got cyberknife for her single mediastinal node. Maybe that is an option to consider.

Julie

[Val Pfeiffer]

Joan--
Are you considering Tykerb?

Val

[chrisy]

Joan, I think that Joy from our site was the 100th person in the phase II 3 week study. Not sure which one of the several studies you were checking on. They do sometimes open for more people, either at a specific institution or overall.

There may also be other, new trials coming up on this.

[runtolive]

http://www.clinicaltrials.gov/ct2/results?term=trastuzumab-MCC-DM1

joan try this link

the not yet recruiting will begin in july according to genentech

u can contact fernandes.michele@gene.com (fernandes.michele%40gene.com?subject=NCT00679341, TDM4450g, A Study of the Efficacy and Safety of Trastuzumab-Mcc-DM1 vs. Trastuzumab (Herceptin®) and Docetaxel (Taxotere®) in Patients With Metastatic HER2-Positive Breast Cancer Who Have Not Received Prior Chemotherapy for Metastatic Disease) for more info..

[Joan M]

Julie, I believe the cyberknife is the same as stereotatic body radiotherapy. I've checked into that and would be eligible, but that's part of the problem of making up my mind about what to do. I have several options, including Tykerb as Val mentioned.

Chrisy and run to live, thanks for the additional trial info. As it turns out, Sloan will be opening phase II in a few months and they directed me to two local sites that have already opened the second phase. One is actually too far away, but I'm going to check out the other one.

[runtolive]

where did sloan direct you to...

United States, New JerseySt. Barnabas Health Care Sys Recruiting Livingston, New Jersey, United States, 07039

Contact: Ilda Boholli 973-322-2470 iboholli@sbhcs.com United States,


New YorkEastchester Center/Cancer Care Recruiting Bronx, New York, United States, 10469

Contact: Karen Hoffman 718-732-4029 karen@eastchestercenter.com



New York Oncology Hematology
Recruiting Albany, New York, United States, 12206

Contact: Mary Beth Biette 518-489-0528 mary.biette@usoncology.com

run

[Joan M]

Run,

Sloan directed me to St. Barnabas and to the Bronx.

Ilda Boholli is no longer at St. Barnabas even though she's listed as the contact, and I spoke instead with with Elyce Hirtler. After we spoke she talked to Dr. Michaelson and then called me back to say that the second segment of the trial is closed. That is, the sponsor Genentech met its quota of 100 and surpassed that by 10 for 110 idividuals. So none of the sites will be recruiting now for this part of the trial.

After I spoke to her, Dr. Modi, the study doctor at Sloan-Kettering, called me from some airport somewhere (what a great lady! And really nice, too!). She explained that the second segement of the trial is closed and that in the fall Sloan will be opening another segment but under more strict enrollment criteria. For this segment of the Phase II trial, patients will have had to progressed on Tykerb and Xeloda. As you probably know, the initial recruitment criteria called for progressing while taking only Herceptin.

Since I haven't taken either Tykerb or Xeloda, I would not be eligible, but some of the sisters (or brothers) on the board may want to look into the trial.

The trial is listed on the NIH website and the full copy of the trial shows all the locations where the trial is available.

Thanks much for all your support.

Joan

[Barbara H.]

Hi,
I had treatment today and asked if phase 1 would be opening again. It is now closed and will not be taking new patients. As far as I know phase 2 is still open.
Barbara H.

[Joan M]

Hi Barbara,

Yes, I think Phase II is still open, but it seems to be rolling out in parts as it progresses, and that the parts close and a new one opens.

Joan