Stand Up 2 Cancer

[Hopeful]

I saw Katie Courick, Charles Gibson and Brian Williams on tv this morning discussing this new initiative. I haven't plowed through it yet, but it looks interesting: http://www.standup2cancer.org/node/275

Hopeful

[abitjaded]

Sounds interesting.

Maybe direct some research money to "non-profit" research. If your CA is rare, there is no profit fro a drug company.

Carla

[Paris]

I do believe Katie Couric said that a portion would be going to "out of the box" research which currently has a shortage of funding. I was shocked at the statistics of one of every two men and one of every three women will be diagnosed with cancer. If only our government would take notice. I am hopeful this effort brings about both awareness and change.

[chrisy]

Let me include a disclaimer, I did not see the program and am completely ignorant! Which doesn't necessarily preclude me from putting 2 cents in (just ask my boss!).

True, there are horrendous barriers to researching rarer cancers - the profit motive isn't there, as you say, but also there are challenges related to just not enough cases to study. On the other hand, there is some motivation to research less treatable conditions because it is "easier" to get approval since any reasonable degree of efficacy is better than no options. That last point, I've heard but do not have data to support it. Note tho, that many of the treatments currently being studied for use in breast cancer (avastin, iressa, etc) were initially approved for other cancers.

So the good thing is, the direction of research has been changing FROM trying to find treatments or cures for cancer of the breast/bowel/lung/whatever body part TO seeking to understand and attack the cancer based on the biology of the cancer cells themselves - such as blocking Her2 signalling (herceptin) or angiogenesis (avastin). These types of biological activities are what makes cancer cells - any cancer cells - grow. So, cancer cells of many types may respond to a given treatment.

[new shoes]

I found this website very refreshing. There is a great article interviewing Dennis Slamon in the magazine section under profiles. He talks about the difficulty he had getting funding for Herceptin and how Stand Up To Cancer will help fund other "outside the box" research.

[Joe]

If this email does not display properly, click here (http://aacr.informz.net/z/cjUucD9taT05ODUyNyZwPTEmdT0xMDAyMTY5NTM1JmxpPTI0MD A2Ng/index.html) to view our online version.To ensure continued delivery of this email, please add SU2C@aacr.org to your email address book. http://aacr.informz.net/aacr/data/images/aacr700w_email_banner08.gifMay 28, 2008
http://aacr.informz.net/aacr/data/images/su2c_spotlight_w22.gif (http://aacr.informz.net/z/cjUucD9taT05ODUyNyZwPTEmdT0xMDAyMTY5NTM1JmxpPTI0MD A2Nw/index.html)The American Association for Cancer Research is pleased to announce its partnership in Stand Up To Cancer (http://aacr.informz.net/z/cjUucD9taT05ODUyNyZwPTEmdT0xMDAyMTY5NTM1JmxpPTI0MD A2Nw/index.html), a new initiative to raise philanthropic dollars for accelerating ground-breaking research which launches today through an unprecedented collaboration uniting the major television networks, entertainment industry executives, celebrities and prominent leaders in cancer research and patient advocacy. ABC, CBS and NBC will donate one hour of simultaneous commercial-free primetime for a nationally televised fundraising event to air on September 5, 2008 (8 pm EDT and PDT), aimed at rallying the public around the goal of ending cancer's reign as a leading cause of death.

New developments in the laboratory are revealing the way cancer begins, progresses and spreads. Stand Up To Cancer is founded on the belief that now, more than ever, there is sufficient knowledge of the basic science of cancer, and that the technologies are available to translate this knowledge into real advances in treatment and prevention. Today's cancer scientists are on the verge of life-saving discoveries, but their progress is hindered by a lack of sufficient research funding. Stand Up To Cancer is dedicated to providing this much needed new source of cancer research funding.

Stand Up To Cancer's innovative approach to research is designed to eliminate barriers that have traditionally inhibited creativity and collaboration by enabling the best and brightest investigators from leading institutions across the country and internationally to work together. These collaborative "Dream Teams" will pursue the most promising research, accelerating the discovery of new therapies for cancer patients and advancing efforts in cancer prevention research. Stand Up To Cancer monies will also be used for some high-risk, high-impact cancer research proposals, which are often not supported by conventional funding sources.

The American Association for Cancer Research (AACR) will provide scientific oversight and will conduct expert scientific review of the research projects and administer funds raised through the initiative under the direction of a Scientific Advisory Committee. Highly regarded for its scientific brain trust in all subfields of cancer research, and for its peer-review process that is fast, flexible, rigorous and transparent, the AACR provides scientific leadership critical to achieving Stand Up To Cancer's mission to translate the most promising cancer research into real advances in cancer treatment and prevention as quickly as possible.

Nobel Laureate Phillip A. Sharp, Ph.D., Institute Professor at the Massachusetts Institute of Technology and the David H. Koch Institute for Integrative Cancer Research at MIT chairs the Scientific Advisory Committee, which includes highly accomplished clinical investigators, senior laboratory researchers and physician-scientists. Arnold Levine, Ph.D., professor in the School of Natural Sciences at the Institute for Advanced Study and professor in the departments of pediatrics and biochemistry at UMDNJ-Robert Wood Johnson Medical School is vice-chair of the Scientific Advisory Committee.

"This project has tremendous potential to change the face of cancer research," said Sharp. "Our goal is to rapidly move new research discoveries out of the lab and into the clinic to save lives from cancer."

"I am pleased that AACR is a partner in the Stand Up To Cancer initiative," said Raymond N. DuBois, M.D., Ph.D., AACR President and Provost and Executive Vice President at M. D. Anderson Cancer Center. "The Stand Up To Cancer model is distinctive because it emphasizes collaboration among scientists and will accelerate translational research on the verge of breakthroughs as well as provide an additional revenue stream to encourage novel, high-risk proposals that have great potential in making inroads against cancer."

The AACR will distribute to the cancer research community a "call for ideas" for research topics in early June. The focal topics and Dream Team leaders will be selected by the Scientific Advisory Committee. Dream Team leaders will recruit members to their Dream Teams with final approval by the Scientific Advisory Committee. More details about submitting ideas for research topics will be available in early June on www.aacr.org.

A Stand Up To Cancer Advocate Advisory Council is being formed, and will include leaders from approximately 25 organizations. Additionally, representatives from the advocacy community will work side-by-side with the scientists on the "Dream Teams," so the perspectives of the patients and survivors they represent will be integrated into the direction of the research.

For more information:
Visit the Stand Up To Cancer (http://aacr.informz.net/z/cjUucD9taT05ODUyNyZwPTEmdT0xMDAyMTY5NTM1JmxpPTI0MD A2OA/index.html) website.
Read the press release (http://aacr.informz.net/z/cjUucD9taT05ODUyNyZwPTEmdT0xMDAyMTY5NTM1JmxpPTI0MD A2OQ/index.html) announcing the campaign.
Review the grant giving model (http://aacr.informz.net/z/cjUucD9taT05ODUyNyZwPTEmdT0xMDAyMTY5NTM1JmxpPTI0MD A3MA/index.html).
See the members of the Scientific Advisory Committee (http://aacr.informz.net/z/cjUucD9taT05ODUyNyZwPTEmdT0xMDAyMTY5NTM1JmxpPTI0MD A3MQ/index.html).
Send this email to a colleague (http://aacr.informz.net/aacr/SendToFriend.asp?brandid=4017&email=christine@her2support.org&mfqid=127269&mi=98527&l=1&returnUrl=http://www.aacr.org) >>

American Association for Cancer Research (http://aacr.informz.net/z/cjUucD9taT05ODUyNyZwPTEmdT0xMDAyMTY5NTM1JmxpPTI0MD A3Mg/index.html)
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