Looking for info?

[penelope]

Can anyone tell me what the prognostic value is of the Mitotic rate of a tumor?

[Lani]

it is a measure of proliferation and reflects the percentage of cells which are in the act of dividing. It seems anything over 10% is usually cited as high and I have seen numbers as high as 50%.

Mitosis is a three syllable word for cell division, so the mitotic rate is the speed with which cells divide (proliferate).

Hope some of this helped

[Brenda_D]

Mine was 70%, and rated "extremely high".

[penelope]

Mine is simply listed as 2/10hpf it is not listed as a percentage. Is this considered low or high?

[kk1]

Hi Penelope;

It is a measure of the percentage of cells undergoing mitosis. They determine this by looking at the cells under high powered viewing field of a microscope. 2/10hpf means that 2 out of 10 cells viewed under the high powered lens (400x) showed active cell division. eg., 20% of your tumor cells were dividing which would give you a mitotic index of 1 on the nottingham grading scale--eg. which is good not very many of the cells were dividing.

you might fine this link useful in regard to how they grade your tumor
http://ccm.ucdavis.edu/bcancercd/311/grading_diagram.html

kk1

[Hopeful]

Penelope,


Here is a link to an article which discusses the prognostic value of Ki-67: http://www.pslgroup.com/dg/24DF4E.htm

Hopeful

[penelope]

Ok I am confused are K167 the same thing as mitotic count or is it like comparing apples to oranges.

How does mitotic count corolate to the percentage given by k167?

I also thought that a 10HPF was the eye piece of the microscope multiplied by the objective below which in the above example would be 40X . Hence 10 x 40 would equal 400 magnification. There for you would see far more cells than just 10 wouldn't you? Am I off the mark here?