eric
02-19-2007, 06:49 PM
http://news.yahoo.com/s/afp/20070130/hl_afp/ushealthcancer
Combination therapy promising for breast cancer: Study
CHICAGO (AFP) - An experimental new treatment for breast cancer can dramatically shrink, and in some cases, eliminate, tumors in mice that have been infected with the disease, a study has said. <SCRIPT language=javascript>if(window.yzq_d==null)window.yzq_d=new Object();window.yzq_d['ipGHBdGDJHQ-']='&U=13b5fr6u1%2fN%3dipGHBdGDJHQ-%2fC%3d571699.10029817.10887929.1442997%2fD%3dLREC %2fB%3d4368327';</SCRIPT><NOSCRIPT>http://us.bc.yahoo.com/b?P=p_QCx0WTVvpCSyPERa7XUw8XSEQjhkXaTo8ACMCD&T=1b1b7o1jr%2fX%3d1171934863%2fE%3d95959690%2fR%3d news%2fK%3d5%2fV%3d2.1%2fW%3dH%2fY%3dYAHOO%2fF%3d2 365163763%2fH%3dY2FjaGVoaW50PSJuZXdzIiBjb250ZW50PS JicmVhc3QgY2FuY2VyO2RydWc7Y2FuY2VyO2l0O0JyZWFzdCBj YW5jZXI7cmVmdXJsX3d3d193b3JsZGhlYWx0aF9uZXQiIHJlZn VybD0icmVmdXJsX3d3d193b3JsZGhlYWx0aF9uZXQiIHRvcGlj cz0icmVmdXJsX3d3d193b3JsZGhlYWx0aF9uZXQi%2fQ%3d-1%2fS%3d1%2fJ%3d96519345&U=13b5fr6u1%2fN%3dipGHBdGDJHQ-%2fC%3d571699.10029817.10887929.1442997%2fD%3dLREC %2fB%3d4368327</NOSCRIPT>
The new therapy involves a combination of a chemotherapy drug, Taxotere (generic name: docetaxel) and a novel compound called JMR-132, that starves the tumor of growth-stimulating hormone. The compound binds to receptors on the tumor, and in so doing blocks the release of the growth hormone.
Tested separately, the drug and the growth factor inhibitor were extremely effective at shrinking the tumors in mice infected with a hard-to-treat, estrogen-independent form of breast cancer.
On its own, the Taxotere reduced the volume of the mice tumors by an average of 74 percent in three weeks. In mice treated with JMR-132, the volume reduction was 63 percent.
Together, the two therapies reduced the volume of the cancerous cells by more than 97 percent. In some cases, when the researchers examined the dead mice, they could not find any cancer cells at all.
What's more, the treatment did not appear to be toxic or trigger any other major side effects in the animals, suggesting it might be well-tolerated in humans, the researchers said.
Combination therapy promising for breast cancer: Study
CHICAGO (AFP) - An experimental new treatment for breast cancer can dramatically shrink, and in some cases, eliminate, tumors in mice that have been infected with the disease, a study has said. <SCRIPT language=javascript>if(window.yzq_d==null)window.yzq_d=new Object();window.yzq_d['ipGHBdGDJHQ-']='&U=13b5fr6u1%2fN%3dipGHBdGDJHQ-%2fC%3d571699.10029817.10887929.1442997%2fD%3dLREC %2fB%3d4368327';</SCRIPT><NOSCRIPT>http://us.bc.yahoo.com/b?P=p_QCx0WTVvpCSyPERa7XUw8XSEQjhkXaTo8ACMCD&T=1b1b7o1jr%2fX%3d1171934863%2fE%3d95959690%2fR%3d news%2fK%3d5%2fV%3d2.1%2fW%3dH%2fY%3dYAHOO%2fF%3d2 365163763%2fH%3dY2FjaGVoaW50PSJuZXdzIiBjb250ZW50PS JicmVhc3QgY2FuY2VyO2RydWc7Y2FuY2VyO2l0O0JyZWFzdCBj YW5jZXI7cmVmdXJsX3d3d193b3JsZGhlYWx0aF9uZXQiIHJlZn VybD0icmVmdXJsX3d3d193b3JsZGhlYWx0aF9uZXQiIHRvcGlj cz0icmVmdXJsX3d3d193b3JsZGhlYWx0aF9uZXQi%2fQ%3d-1%2fS%3d1%2fJ%3d96519345&U=13b5fr6u1%2fN%3dipGHBdGDJHQ-%2fC%3d571699.10029817.10887929.1442997%2fD%3dLREC %2fB%3d4368327</NOSCRIPT>
The new therapy involves a combination of a chemotherapy drug, Taxotere (generic name: docetaxel) and a novel compound called JMR-132, that starves the tumor of growth-stimulating hormone. The compound binds to receptors on the tumor, and in so doing blocks the release of the growth hormone.
Tested separately, the drug and the growth factor inhibitor were extremely effective at shrinking the tumors in mice infected with a hard-to-treat, estrogen-independent form of breast cancer.
On its own, the Taxotere reduced the volume of the mice tumors by an average of 74 percent in three weeks. In mice treated with JMR-132, the volume reduction was 63 percent.
Together, the two therapies reduced the volume of the cancerous cells by more than 97 percent. In some cases, when the researchers examined the dead mice, they could not find any cancer cells at all.
What's more, the treatment did not appear to be toxic or trigger any other major side effects in the animals, suggesting it might be well-tolerated in humans, the researchers said.