Has Anyone Been On Bibw 2992?

[vickie h]

I will be starting on BIBW 2992 ( a Tyrosine Kinase Inhibitor like Tykerb) in a couple of weeks. It is phase II and my Onc thinks it is as good or better than tykerb. I have been on Herceptin for 3 years and she feels it is no longer effective. Does anyone have any knowledge about this new drug from Germany? I have been all over the internet but would love any feedback from this wonderful group. Much love and prayers to you all, Vickie

[Kimberly Lewis]

Hi Vic, Sorry - I have never heard of it - but did look it up! Sounds promising and I hope you will keep us informed as to how you do and if you could reccomend it or not! I hope someone else can answer who is better informed than I.. Good luck with it, I will keep you in my prayers!

[Lani]

Personalized Results 1 - 10 of about 838 for BIBW 2992. (0.35 seconds)
News - The EGFR/HER2 Tyrosine Kinase Inhibitor BIBW 2992 Well ...
The EGFR/HER2 Tyrosine Kinase Inhibitor BIBW 2992 Well Tolerated: Presented at AACR-NCI-EORTC.
www.docguide.com/news/content.nsf/ news/8525697700573E18852570C0004A44E6 - 80k - Cached - Similar pages
News - A 2-Week-On, 2-Week-Off Schedule Appears Optimal for BIBW ...
BIBW 2992 is a highly selective potent irreversible dual inhibitor of the ... They concluded that BIBW 2992 was safe in patients given a 2-week-on, ...
www.docguide.com/news/content.nsf/ news/8525697700573E18852570C0006232FF - 79k - Cached - Similar pages
ASCO - Phase 1 study with BIBW 2992, an irreversible dual tyrosine ...
A phase 1 study of orally administered BIBW 2992 was performed to determine its safety, ... In cycle 1 and 2, BIBW 2992 plasma PK analysis was performed. ...
www.asco.org/portal/site/ASCO/ menuitem.34d60f5624ba07fd506fe310ee37a01d/?vgnextoid=76f8201eb61a7010VgnVCM... - 57k - Cached - Similar pages
[PDF]
1 of 3 “A Phase I Open-Label Dose Escalation Study of Continuous ...
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Treatment with BIBW 2992 in Patients with Advanced Solid Tumors” ... period, the patient will be given BIBW 2992 at the same dose as other patients in the ...
www.csmc.edu/pdf/wwwbibwb.pdf - Similar pages
[PDF]
1 of 2 “A Phase I Open-Label Dose Escalation Study of Continuous ...
File Format: PDF/Adobe Acrobat - View as HTML
Treatment with BIBW 2992 in Patients with Advanced Solid Tumors” ... The particular growth factor receptors that BIBW 2992, research drug, ...
www.csmc.edu/pdf/wwwbibwa.pdf - Similar pages
Boehringer Ingelheim Deutschland: Sci_Pub
Methods BIBW-2992 was administered orally once daily starting at 10 mg/day ... Exploring two different dosing schedules, BIBW 2992 was continuously orally ...
www.boehringer-ingelheim.de/ forschung/scipub/sci_pub.jsp?gebiet=Onkologie - 195k - Cached - Similar pages
Clinical Trial: An Open Label Phase II Trial of BIBW 2992 in ...
The purpose of this trial is to evaluate the efficacy, safety and pharmacokinetics of BIBW 2992, a dual, irreversible EGFR- and HER2-inhibitor, ...
clinicaltrials.gov/ct/show/NCT00425854; jsessionid=9BD9036275E6D61A872727859FE7D77C?order= 35 - 18k - Cached - Similar pages
Xcovery blog - kinase industry knowledge collected and sometimes ...
Showing posts with label BIBW-2992. Show all posts. Showing posts with label BIBW-2992. ... BIBW-2992 - targeting EGFR and Her-2 BI-2536 - targeting Plk-1 ...
xcovery.blogspot.com/search/label/BIBW-2992 - 89k - Cached - Similar pages
Phase 1 study with BIBW 2992, an irreversible dual tyrosine kinase ...
Background: BIBW 2992 is a highly selective, potent, irreversible tyrosine inhibitor of EGFR and HER2. A phase 1 study of orally administered BIBW 2992 was ...
meeting.jco.org/cgi/content/abstract/24/18_suppl/3025 - Similar pages
A phase I dose escalation study of BIBW 2992, an irreversible dual ...
Background: BIBW 2992 is a novel, potent, orally bioavailable irreversible ... Methods: BIBW 2992 was administered orally as a continuous once daily dose ...
meeting.jco.org/cgi/content/abstract/24/18_suppl/2074 - Similar pages

[vickie h]

Thanks Kim! I've been finding out all I can and hope that this is the right thing for me. I also have a choice of doing Xeloda instead but it is hard to make the choice right now. My Oncologist said that this drug is from Germany and is the same thing as Tykerb under a different name. I will let you know how things go, as I start in 2 weeks. Much love and prayers to you always, Vickie

[Janet Ruth]

Hi Vicki:

How did it go with your BIBW 2992 trial? (not sure how this works - never been on a forum before......) I am considering starting a Phase II trial in Boston that's open. Herceptin is no longer effective after a year. It's either this, radiation to the site or Tykerb. Not sure what I want to do. Heading back down to Boston for yet another opinion for possible options.

Janet Ruth

[vickie h]

Hi Janet, I did the phase II trial for BIBW for about 10 days, it completely knocked out the skin mets but I was so sick, diarhea, horrible face rash that was painful and just plain awful. They reduced my dose but still too strong, so I took 4 weeks off and have been on Xeloda?Tykerb for about a month and I am doing great. The Tykerb is fantastic and I have no skin mets at all (they came back quickly in that 4 week rest period). I also have hardly any symptoms with the Xeloda (I am taking a reduced dose) or the Tykerb ( I am taking the full 5 tablets). If there is anything I can do to help let me know. Should you experience difficulties with the BIBW, there is also a HKI trial, phse III going on. It is so similat to BIBW and Tykerb, Just minute differences in the formulas, bbut they are all Tyrosine Kinase Inhibitors. Let me know what you decide. Love and Hugs, Vickie

[Mary Jo]

I never heard of that either. What is it?

Mary Jo

[vickie h]

Mary Joe, HKI 272 can be googled. It is a drug very much like the BIBW and Tykerb. I am on Tykerb and it is doing the trick. Let me know if I can find out any more info for you. I know HKI272 is on the clinicaltrials.com site (I think). Love, Vickie