Help

[hannah]

I have popped in and out of this forum and have always recieved alot of great information. I am now desperate, my sister, maybe Patty and Joe may recall, has breast cancer with brain mets which has been treated with WBR, Gamma Knife and more recently Xeloda which unfortunately has now stopped working. Here in UK a trial at Christies for Tykerb has been stopped and dont now what to do, has anybody had any other chemo which we can ask about, the oncologist is willing to try. My sister has 2 little girls and we are not ready to lose her yet I would be grateful for any info
Hannah

[tricia keegan]

Hannah I'm sorry to hear about your sister.

I know someone from another site who had a chemo called
Temodar (sp?) for brain mets and did very well on it.
I hope someone else can help you with more details.

Tricia

[Lani]

a most remarkable article--I felt it inappropriate to place it with interesting articles as only one tenth as many her2support readers view those posts and it is my impression that there are some out there who could definitely need this news, published in a very respectable journal

I was happy to see an email address attached to the abstract and have forwarded on more information...


1: J Neurooncol. 2006 Sep 26; [Epub ahead of print] Links
A lipoxygenase inhibitor in breast cancer brain metastases.

Flavin DF.
Foundation for Collaborative Medicine and Research, 24 Midwood Drive, Greenwich, CT, 06831, USA, Dana_FK@hotmail.com.
The complication of multiple brain metastases in breast cancer patients is a life threatening condition with limited success following standard therapies. The arachidonate lipoxygenase pathway appears to play a role in brain tumor growth as well as inhibition of apoptosis in in-vitro studies. The down regulation of these arachidonate lipoxygenase growth stimulating products therefore appeared to be a worthwile consideration for testing in brain metastases not responding to standard therapy. Boswellia serrata, a lipoxygenase inhibitor was applied for this inhibition. Multiple brain metastases were successfully reversed using this method in a breast cancer patient who had not shown improvement after standard therapy. The results suggest a potential new area of therapy for breast cancer patients with brain metastases that may be useful as an adjuvant to our standard therapy.
PMID: 17001517 [PubMed - as supplied by publisher]

I think someone else has posted on Boswellia serata--ie whether trials, etc

[hannah]

Has anybody had chemo called Symadex, for brain mets and if so how has it worked .

thanksfor any help hannah

[sarah]

Dear Hannah,
what about looking into Tykerb in other European countries?
If she can have biopsies, I know there is one in Marseilles, France.
Good luck,
sarah