Finished Late Herceptin; Maybe Moving on to the E75 Vaccine

[Barbara2]

I am concidering the E75 Trial, now that I have finished 1 year of late herceptin. In May of 06, someone posted here that an onc and a phase I trial specialsist at the U of Colorado had recommended against the Her2 vaccines due to the possibility that T cells from vaccinated patients have shown to not be able to kill Her2 tumors; that possibly the cancer vaccine could make the immune system resistant to cancer.

That is the only time I have heard of this concern. Is anyone aware of other information that would support that idea?

I talked to someone yesterday from the Windber Medical Center to express my interest in possibly participating in the vaccine trial. I would like to concider the idea, but would like to know more about the vaccine making the immune system resistant to cancer.

Does anyone have anything to add? Thanks!

Barb

[Kim in DC]

Barb,

The E75 vaccine is the only one that I qualify for. I have done all my research on this vaccine. I have not entered the trial yet because I wanted to stay on Herceptin and currently, you can not take them both at the same time. I mention all this to say that all of the information that I have received is from the trial nurse directly, Maureen Pavlik. I even got an email from Dr. Peeples who initiated the vaccine. If you have specific questions, ask Maureen. Ask her for any data she has as well. If you find out anything new, share it with us.

Kim in DC

[alw]

I think this is the post to which you were referring...? I was wondering about this, too. I have not heard this anywhere else but here. Clearly, autoimmunity would be a major concern with vaccines, but I'm not sure that I've seen anyone address the issue directly.




posted by MaryD May 2006

"vaccine concerns?
has anyone heard concerns about a cancer vaccine making the immune system resistant or tolerant to the cancer? ive spoken to my science friends and my oncologist who say this is a big concern with peptide vaccines. i also saw a phase I trial specialist at u. colorado who recommended against the HER2 vaccines given at u. washington (seattle) for that reason. she said it could make the immune system tolerant, and that t cells from vaccinated patients have been shown to not be able to kill her2 positive tumors anymore. thoughts?"