R.B.
06-03-2006, 04:12 AM
Thought provoking.
Does mutation arise or is it inherited.
What triggers it acting in this way, as if inherited it has been around a long time and BC has increased by leaps and bounds.
The genes may increase risk but what are the triggers.
And look at the disease in apparently connects to - familiar territory?
RB
http://www.innovations-report.de/html/berichte/biowissenschaften_chemie/bericht-60620.html
ABSTRACT
The team, led by cell biologist Michael P. Lisanti, M.D., Ph.D., professor of cancer biology at Jefferson Medical College and Richard Pestell, M.D., Ph.D., director of Jefferson’s Kimmel Cancer Center, found that a known mutation in the Caveolin-1 gene is present in approximately 19 percent of all breast cancers that are fed by estrogen – so called “estrogen receptor-positive” cells. The group also discovered six new Caveolin-1 mutations associated with estrogen-driven breast cancers. As many as nearly 35 percent of such breast cancers may carry Caveolin-1 mutations, Dr. Lisanti says. Caveolin proteins, which play important roles in cell communication, are also involved in a number of diseases and conditions, such as cancer, atherosclerosis, diabetes, Alzheimer’s disease and muscular dystrophy.
Does mutation arise or is it inherited.
What triggers it acting in this way, as if inherited it has been around a long time and BC has increased by leaps and bounds.
The genes may increase risk but what are the triggers.
And look at the disease in apparently connects to - familiar territory?
RB
http://www.innovations-report.de/html/berichte/biowissenschaften_chemie/bericht-60620.html
ABSTRACT
The team, led by cell biologist Michael P. Lisanti, M.D., Ph.D., professor of cancer biology at Jefferson Medical College and Richard Pestell, M.D., Ph.D., director of Jefferson’s Kimmel Cancer Center, found that a known mutation in the Caveolin-1 gene is present in approximately 19 percent of all breast cancers that are fed by estrogen – so called “estrogen receptor-positive” cells. The group also discovered six new Caveolin-1 mutations associated with estrogen-driven breast cancers. As many as nearly 35 percent of such breast cancers may carry Caveolin-1 mutations, Dr. Lisanti says. Caveolin proteins, which play important roles in cell communication, are also involved in a number of diseases and conditions, such as cancer, atherosclerosis, diabetes, Alzheimer’s disease and muscular dystrophy.