Top Abstracts in Breast Cancer 02/22/2006

[al from Canada]

TopAbstracts - Past 7 days




Vinorelbine in the management of breast cancer: New perspectives, revived role in the era of targeted therapy (http://www.docguide.com/news/content.nsf/WebOpenPaper_TopAbstracts?OpenAgent&newsid=852571020057CCF68525711600313A21) - (Cancer Treat Rev)
Incidence, Time Course, and Determinants of Menstrual Bleeding After Breast Cancer Treatment: A Prospective Study (http://www.docguide.com/news/content.nsf/WebOpenPaper_TopAbstracts?OpenAgent&newsid=852571020057CCF6852571170079FC1F) - (J Clin Oncol)
Breast cancer: achievements in adjuvant systemic therapies in the pre-genomic era (http://www.docguide.com/news/content.nsf/WebOpenPaper_TopAbstracts?OpenAgent&newsid=852571020057CCF6852571180030EF73) - (Oncologist)
Clinical experience with pemetrexed in breast cancer (http://www.docguide.com/news/content.nsf/WebOpenPaper_TopAbstracts?OpenAgent&newsid=852571020057CCF68525711600302434) - (Semin Oncol)
Role of gemcitabine in breast cancer management: an update (http://www.docguide.com/news/content.nsf/WebOpenPaper_TopAbstracts?OpenAgent&newsid=852571020057CCF68525711600302482) - (Semin Oncol)


TopAbstracts - Past 3 months


Two Concurrent Phase II Trials of Paclitaxel/ Carboplatin/Trastuzumab (Weekly or Every-3-Week Schedule) as First-Line Therapy in Women with HER2-Overexpressing Metastatic Breast Cancer: NCCTG Study 983252 (http://www.docguide.com/news/content.nsf/WebOpenPaper_TopAbstracts?OpenAgent&newsid=8525697700573E18852570E90036DC1E) - (Clin Breast Cancer)
Adjuvant chemotherapy for early breast cancer: optimal use of epirubicin (http://www.docguide.com/news/content.nsf/WebOpenPaper_TopAbstracts?OpenAgent&newsid=8525697700573E18852570CA002E5F60) - (Oncologist)
Dose-Dense Adjuvant Chemotherapy in Early Breast Cancer Patients: Results From a Randomized Trial (http://www.docguide.com/news/content.nsf/WebOpenPaper_TopAbstracts?OpenAgent&newsid=8525697700573E18852570D2002DA237) - (J Natl Cancer Inst)
Pre-operative systemic (neo-adjuvant) therapy with trastuzumab and docetaxel for HER2-overexpressing stage II or III breast cancer: results of a multicenter phase II trial (http://www.docguide.com/news/content.nsf/WebOpenPaper_TopAbstracts?OpenAgent&newsid=8525697700573E18852570D2002D8099) - (Ann Oncol)
Comparison of rapidly cycled tandem high-dose chemotherapy plus peripheral-blood stem-cell support versus dose-dense conventional chemotherapy for adjuvant treatment of high-risk breast cancer: results of a multicentre phase III trial (http://www.docguide.com/news/content.nsf/WebOpenPaper_TopAbstracts?OpenAgent&newsid=8525697700573E18852570D0002EDC9A) - (Lancet)

[Bev]

Haven't figured out how to start a new thread, short attention span. I think there is some relevance here


SAN FRANCISCO, Feb. 25 -- Researchers said Friday that they have found a virus in the prostates of some cancer patients, a remarkable discovery that may suggest disease could play a role alongside genetics and the environment in causing this cancer.

The virus, closely related to one previously found only in mice, was found in cancerous prostates removed from men with a certain genetic defect. The findings open new avenues for studying the most common major cancer among men in the United States.


Biotechnology

Researchers and regulators are reshaping the landscape of science, medicine and health, engendering hope -- and disquiet -- for the future of humanity.




The Stork Market (http://www.washingtonpost.com/wp-dyn/content/article/2006/02/23/AR2006022301680.html)
Virus Is Discovered In Cancerous Prostates (http://www.washingtonpost.com/wp-dyn/content/article/2006/02/24/AR2006022401787.html)
Virus Found in Prostate Cancer Patients (http://www.washingtonpost.com/wp-dyn/content/article/2006/02/24/AR2006022400234.html)
Wider Flu Vaccination Urged (http://www.washingtonpost.com/wp-dyn/content/article/2006/02/22/AR2006022202080.html)
Panel Recommends Flu Shots for Kids (http://www.washingtonpost.com/wp-dyn/content/article/2006/02/22/AR2006022201773.html) More News (http://www.washingtonpost.com/wp-dyn/content/technology/special/02)


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setTimeout('update_delicious_form(delicious_cookie )',1) The researchers, with the University of California at San Francisco and the Cleveland Clinic, presented the findings at an American Society of Clinical Oncology meeting in San Francisco. They warn that they have not found any links between the virus and prostate cancer, but they are nonetheless excited about prospects for future research.

"We have made a very fascinating discovery never before seen in humans that is very similar to one found in a mammal that causes cancer," Eric Klein of the Cleveland Clinic said at a news conference. "But we have not proven this virus causes prostate cancer."

Infectious-disease-causing viruses are already blamed for some liver cancers and cervical cancer. That has planted nagging suspicions in the minds of scientists that some diseases may play important roles alongside genetics, environment and chance in causing breast, stomach and several other forms of cancer.

Researchers are not sure how the mouse virus infected people, but they suspect it has been passed on genetically for many generations.

"This is a class of virus no one would have looked for in prostate cancer," said UCSF researcher Joe DeRisi, who developed the "gene chip" that made the discovery. DeRisi's chip contains 20,000 snippets of vital genetic material from every known virus. It is the same chip that confirmed a previously undiscovered virus in the cold family that caused the SARS outbreak three years ago.

Klein sent samples of 86 cancerous prostates he removed from patients to DeRisi. DeRisi then placed DNA from the cancerous tissues on the chip, and DNA from eight of 20 patients with two copies of a mutated gene matched with DNA from the mouse virus.

The gene is a vital cog in the body's defense system, coding for an enzyme that helps kill invading viruses. The men with the mutated genes make fewer such enzymes than those with normal versions of the gene.

The virus was found in just one of the 66 other patients, suggesting that genetics plays a significant role in the virus's connection to cancer.

The researchers said they will now test hundreds more prostate patients and are developing a diagnostic tool to test for the virus in the blood. That way they could test thousands of patients and non-patients alike and figure out if there is any link between prostate cancer and the virus, which causes cancer in mice.