I need a path report 101 ???

[Alice]

Hi,

I just got my path report from my core biopsy and wonder if anyone can help me understand what it all means.It reads as follows:

Invasive ductal carcinoma, poorly differentiated, Nottingham scores:2 (tubular formation) +3 (nuclear grade) +3 (mitotic activity)=8/9, grade 3, with focal necrosis.
- INVOLVING 3 OUT OF 3 CORDS.
- NO DIFINITIVE LYMPHOVASCULAR INVASION SEEN

ER negative (0%)
PR negative (0%)
Her2/neu positive (2+/3+)
K167 positive (90%)
P53 positive (90%)

FISH test: The ratio of Her-2 to chromosome 17 centomere is 5.20.


I know what er/pr and her2 are and what they mean but what are the k167 and p53?
also what are they reffering to when they say 3 out of 3 cords?
and how good or bad is a 5.20 ratio on the fish?

If anyone can give me some help with this I would greatly appreciate it.

Thanks a bunch, Alice

[Joe]

Here is a link to a good guide on pathology reports:

http://www.breastcancer.org/pathology_report.pdf


Regards
Joe

[tousled1]

Joe,


That's an excellent site that explains the pathology report.

[Alice]

Thank you Joe that site is verry helpfull.

Alice

[CLTann]

Hi,


Your path report says that you have an aggressive type of tumor, the negative ER/PR indicates the tumor will not respond to hormone inhibiting drugs such as tamoxifen, the HER2 positive indicates a good chance of favorable response to Herceptin (with chemo) and you should endorse a strong treatment plan.

I thought by interpretting the mythical words into common English, you would get the main message.

There are many effective ways to treat breat cancers of various type. Hope you find a good onc and a successful fight. We are all behind you to support the battle.

Ann

[Bev]

Hi, Run a search on this site. I know there was a thread where people discussed their fish scores in the last few months. I have no idea about the cords. Maybe coordinates? Good Luck. BB