jhandley
02-02-2006, 09:18 PM
Hi all
I came across this info. today:
Proceedings of the National Academy of Sciences (1998; 95):When CoQ10 was administered to middle-age and old-age rats, the level of CoQ10 increased by 10% to 40% in the cerebral cortex region of the brain. This increase was sufficient to restore levels of CoQ10 to those seen in young animals. After only two months of CoQ10 supplementation, mitochondrial energy expenditure in the brain increased by 29%, compared with the group not getting CoQ10. The human equivalent dose of CoQ10 to achieve these results is 100 to 200 mg a day. When a neuro-toxin was administered, CoQ10 helped protect against damage to the striatal region of the brain where dopamine is produced. When CoQ10 was administered to rats genetically bred to develop amyotrophic lateral sclerosis (ALS or Lou Gehrig’s disease), a significant increase in survival time was observed. The scientists concluded: "CoQ10 can exert neuroprotective effects that might be useful in the treatment of neurodegenerative diseases." This new study showed that short-term supplementation with moderate amounts of CoQ10 produced profound anti-aging effects in the brain. Previous studies have shown that CoQ10 may protect the brain via several mechanisms, including reduction in free radical generation and protection against glutamate-inducted excito-toxicity. The study documented that orally supplemented CoQ10 specifically enhanced metabolic energy levels of brain cells. While this effect in the brain has been previously postulated, the new study provides hard-core evidence."
So...
If Q10 crosses the blood brain barrier (which it does) and has an anticancer effect (partic. in high doses 300-400 mg) I am wondering whether it might prevent or delay mets to the brain. If members who have/had brain mets. could possibly post and let us know if they were on Q10 at all and what doses and also if members who dont have brain mets but have had other mets could post too particularly if using >200mg/day it might provide some info. fro us all.
Jackie
I came across this info. today:
Proceedings of the National Academy of Sciences (1998; 95):When CoQ10 was administered to middle-age and old-age rats, the level of CoQ10 increased by 10% to 40% in the cerebral cortex region of the brain. This increase was sufficient to restore levels of CoQ10 to those seen in young animals. After only two months of CoQ10 supplementation, mitochondrial energy expenditure in the brain increased by 29%, compared with the group not getting CoQ10. The human equivalent dose of CoQ10 to achieve these results is 100 to 200 mg a day. When a neuro-toxin was administered, CoQ10 helped protect against damage to the striatal region of the brain where dopamine is produced. When CoQ10 was administered to rats genetically bred to develop amyotrophic lateral sclerosis (ALS or Lou Gehrig’s disease), a significant increase in survival time was observed. The scientists concluded: "CoQ10 can exert neuroprotective effects that might be useful in the treatment of neurodegenerative diseases." This new study showed that short-term supplementation with moderate amounts of CoQ10 produced profound anti-aging effects in the brain. Previous studies have shown that CoQ10 may protect the brain via several mechanisms, including reduction in free radical generation and protection against glutamate-inducted excito-toxicity. The study documented that orally supplemented CoQ10 specifically enhanced metabolic energy levels of brain cells. While this effect in the brain has been previously postulated, the new study provides hard-core evidence."
So...
If Q10 crosses the blood brain barrier (which it does) and has an anticancer effect (partic. in high doses 300-400 mg) I am wondering whether it might prevent or delay mets to the brain. If members who have/had brain mets. could possibly post and let us know if they were on Q10 at all and what doses and also if members who dont have brain mets but have had other mets could post too particularly if using >200mg/day it might provide some info. fro us all.
Jackie