PTEN activity could be a predictive marker of trastuzumab efficacy in the...

[RhondaH]

treatment of ErbB2-overexpressing bc.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16404430&dopt=Citation

Rhonda

[al from Canada]

thanks Rhonda,

So, are there any natural PTEN inducers?
Al

[Becky]

Natural Pten activators is beta glucan, the active ingredient in maitake mushrooms.


Becky

[Maryanne]

http://www.cancure.org/beta_glucan.htm

interesting site on beta glucan

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WHAT IS BETA GLUCAN


Beta Glucan is primarily cultured extract of Baker's Yeast cell wall. It is used as an immunostimulant. Beta glucans are sugar molecules (polysaccharides). They are found bound together as a sugar/protein complex. Certain plants and microorganisms are naturally high in this polysaccharide compound. The richest concentrated source is baker's yeast cell walls. (Because there is basically no yeast left in the products and they have low protein levels, it is considered hypoallergenic.) It is present in lesser amounts in mushroom extracts and Lentinen, Barley, Oat, etc. Sodium alginate is also an excellent source, but the high sodium content is a major drawback in the processing for supplemental use. An expensive research extract called Zymosan™ has been used for doing research for over 45 years. Much of the research has been in combining it with conventional approaches, such as chemotherapy, but it has been found to work well on its own.

What glucans seem to do is to stimulate/irritate your white blood cells called Macrophages into action. There is actually beta glucan receptors displayed by immune cells that the lectin fits right into like a lock and key and switches on or activates the macrophage to do it's job...clean up. Increased macrophage activity triggers a whole cascade of immune events, which basically boost immune response, which improves Natural Host Resistance. It also stimulates the production of immune cells.

It is proven beneficial for conditions related to immunity. Here are a few of the abstract references available:


Anti-Tumor Effects. Mediates Destruction of Malignant Cells (J. Nat'l. Cancer Inst. 54, No.3:571, 1975
Inhibits Tumor Growth & Enhances Survival Rates (Adv. Exp. Med. Biol. 121A: 269-290, 1980)
Stimulates Tumor Cell Destruction (Scand.J.Immunol. 15:297-304 / Diss.Abst. Int.Sci. 48:1263, 1987)
Inproved Host Resistance to all types of different infections (Trends in Pharm.Sciences, 433:344-347, 1983)
Haults & Reverses Radiation Damage. (Radiation Research 117:59-69, 1989 / USAF Radiobioklogy Inst., Bethesda, MD)
Immunomodulation and anti-cancer activity of polysaccharide-proteincomplexes.
Curr Med Chem 2000 Jul;7(7):715-29/ Ooi VE, Liu F./ Department of Biology, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong. http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10702635&dopt=Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10702635&dopt=Abstract)
In Japan, extracts containing various types of Beta glucan have been used to successfully assist in treating cancer patients for the last 20 years. See Aoki, T. Chapter 4, Lentinan. In: Modulation Agents and their Mechanism. Richard L. Fenichel (Ed), Marcel Dekker, Inc., New York and Basel, pp 63-77 (1984).

There appears to be a synergistic relationship between Beta-Glucan and Vitamin C, so many clinics combine both in their treatments. Some of the clinics who use it in their treatments include: Europa Clinic (http://www.cancure.org/europa_clinic.htm) and many clinics in Japan.

Sources of the product include:

http://www.arrowheadhealthworks.com/ (http://www.arrowheadhealthworks.com/)





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[Becky]

Maryanne

That is very interesting. Especially since about a week ago, Al and I were conversing on P13K inhibitors (natural ones). You might remember the selenium thread. Brewer's yeast is very high in selenium too. So brewer's yeast, if you can tolerate it, is a good source of beta glucan (Pten activator) and selenium (p13K inhibitor).

Very interesting. Thanks for posting.

Becky

[Maryanne]

Below article to long to paste had some interesting alternatives for her1, cox 2, as well as pten. Like Robin said Her 2 is not the only enemy in this fight.


http://www.centrehealing.com/Resources/A%20Novel%20Approach%20to%20Cancer.pdf

[Maryanne]

Becky,
Not to "beat a dead horse" but Dr Larry Norton , (Head of BC at Sloanes) addressed the New Mexico Cancer Care Alliance ( see entire article on Cancer Care website)
"People who take supplements to "boost their immune system" to fight cancer may not be on the right track. The immune system can stimulate inflammation, and inflammation actually is tied to the development of some cancers, he said. "I'm very concerned about some things in the health food stores ... they may turn out in the long run to be bad," he said."
I am trying to find something with regard to Her2 and inflammation but as yet havent, maybe someone else has. Til then I will continue taking those "magic mushrooms"
Maryanne
PS I do know Epstein Barr causes inflammation

[RhondaH]

I'll buy some brewers yeast and put THAT on my salad too (this is becoming QUITE the concoction, but who cares if it keeps me alive:)

Rhonda

[michele u]

This is veryyyyy interesting about the maitake mushrooms being a pten inhibitor. I have been taking them since dx because, well, because someone on this site told me to!!! I really didn't know what they were doing for me, but i knew they worked for alot of women. Now that i know they are pten inhibitors , i'm ordering another batch!!

[Jeff]

Check this out for interesting info on beta glucan as enhancer of monoclonal antibodies...

Ever since reading this (and while Rachel was on herceptin) I have been ordering a powerful beta glucan for her from Nature's Balance.

Best to all,
Jeff


http://tinyurl.com/awcs9