Binding up the estrogen receptor

[RobinP]

Has anyone heard or read where retinic acid, a derivative of vit A binds up the estrogen receptor to decrease proliferation events? I thought I just read that somewhere but now can't find that reference. I wonder when they are going to find if soy products and phytoestrogens down regulate or upregulate estrogen?

[Unregistered]

I do not recal having seen a retinic acid. I searched NCBI adh there was only ony referecne which looked like it might be a spelling error.

There is a retinoic acid which does relate according to the trials to breast cancer.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed

It also from memory features heavily in the PPAR fat pathways in the liver and is involved in the omega three and six pathways.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed


Retinoic acid is in the same basket as retinoids vitiman a etc, and has a relation to dietary intake, and can act as hormones (as can fats).

It is a subject I have not read much about and only seen bits in passing - more reading when I get time - but all leading back to diet - folates from green things also feature in the functioning of the PPAR pathways.

Hence my constant comments as to the complexity of it all, and diet having to be a good starting place.

http://lpi.oregonstate.edu/infocenter/vitamins/vitaminA/

http://66.102.9.104/search?q=cache:lYJeYb5PVsgJ:www.chori.org/investigators/VitaminA.pdf+retinoic+acid+food+sources&hl=en&lr=lang_en&client=firefox-a

I hope that helps. Sorry I cannot be more specific.

RB

[RobinP]

Thanks for the input RB.