Tom
12-27-2005, 12:45 AM
I have been looking into this one for some time now. I have decided to add this to Mom's daily supplements via LEF.org's formulation of CoQ-10, which now contains d-limonene. D-limonene is also available as a single supplement from TheVitaminShoppe.com
http://www.mskcc.org/mskcc/html/11571.cfm?RecordID=493&tab=HC#drugherb
Here is a brief excerpt from the article:
MECHANISM OF ACTION
The exact mechanism of action is unknown. D-Limonene and its metabolites, perillic acid, dihydroperillic acid, uroterpenol, and limonene1,2-diol, may inhibit tumor growth via inhibition of p21-dependent signaling and apoptosis resulting from induction of the transforming growth factor beta-signaling pathway (4) (http://www.mskcc.org/mskcc/html/11571.cfm?RecordID=493&tab=HC#ref) (8) (http://www.mskcc.org/mskcc/html/11571.cfm?RecordID=493&tab=HC#ref). D-Limonene metabolites also cause G1 cell cycle arrest, inhibit posttranslational modification of signal transduction proteins, and cause differential expression of cell cycle- and apoptosis-related genes (6) (http://www.mskcc.org/mskcc/html/11571.cfm?RecordID=493&tab=HC#ref). Animal studies show activity of D-limonene against pancreatic, stomach, colon, skin, and liver cancers (3) (http://www.mskcc.org/mskcc/html/11571.cfm?RecordID=493&tab=HC#ref). Data also indicate that D-limonene slows the promotion/progression stage of carcinogen-induced tumors in rats (9) (http://www.mskcc.org/mskcc/html/11571.cfm?RecordID=493&tab=HC#ref) (11) (http://www.mskcc.org/mskcc/html/11571.cfm?RecordID=493&tab=HC#ref).
http://www.mskcc.org/mskcc/html/11571.cfm?RecordID=493&tab=HC#drugherb
Here is a brief excerpt from the article:
MECHANISM OF ACTION
The exact mechanism of action is unknown. D-Limonene and its metabolites, perillic acid, dihydroperillic acid, uroterpenol, and limonene1,2-diol, may inhibit tumor growth via inhibition of p21-dependent signaling and apoptosis resulting from induction of the transforming growth factor beta-signaling pathway (4) (http://www.mskcc.org/mskcc/html/11571.cfm?RecordID=493&tab=HC#ref) (8) (http://www.mskcc.org/mskcc/html/11571.cfm?RecordID=493&tab=HC#ref). D-Limonene metabolites also cause G1 cell cycle arrest, inhibit posttranslational modification of signal transduction proteins, and cause differential expression of cell cycle- and apoptosis-related genes (6) (http://www.mskcc.org/mskcc/html/11571.cfm?RecordID=493&tab=HC#ref). Animal studies show activity of D-limonene against pancreatic, stomach, colon, skin, and liver cancers (3) (http://www.mskcc.org/mskcc/html/11571.cfm?RecordID=493&tab=HC#ref). Data also indicate that D-limonene slows the promotion/progression stage of carcinogen-induced tumors in rats (9) (http://www.mskcc.org/mskcc/html/11571.cfm?RecordID=493&tab=HC#ref) (11) (http://www.mskcc.org/mskcc/html/11571.cfm?RecordID=493&tab=HC#ref).