Elaine, UK
12-04-2003, 08:30 AM
To all interested parties and also to Patty H who was interested in this:
Re my msg a while ago on this subject, I spoke with my oncologist yesterday who told me of Methotrexate (in HIGH dose) which apparently crosses the blood brain barrier.
He explained that for every 100 molecules of this drug, 1 molecule gets through to the brain. Accordingly this is for very high doses of the drug and it requires an overnight stay in hospital so that when the drug has done what it needs to do, they then give folinic acid (not folic acid) which ensures that the rest of the body does not endure an overdose.
Accordingly it has been done for years and this man worked at the Dana Cancer hospital, Boston where it is used. See link:
http://www.dana-farber.net/
Apparently the treatment is given every 2 weeks, 8 cycles in all.
Possible links when I typed in "Methotrexate Blood Brain" on the Internet were the following:
http://www.springerlink.com/app/home/contribution.asp?wasp=flmhnmwhxhrd367rvvtk&referrer=parent&backto=issue,15,15;journal,74,157;linkingpublicati onresults,id:100473,1
This link was also interesting and referred to other drugs that cross the blood brain barrier:
http://www.virtualtrials.com/levin1.cfm?printer=Y
This is another GOOD one and refers to the Boston hospital. Apparently it was developed by Dr. Isaac Djerassi:
http://www.iptmd.com/new_page_9.htm
Hope this helps and good luck.
Elaine
Re my msg a while ago on this subject, I spoke with my oncologist yesterday who told me of Methotrexate (in HIGH dose) which apparently crosses the blood brain barrier.
He explained that for every 100 molecules of this drug, 1 molecule gets through to the brain. Accordingly this is for very high doses of the drug and it requires an overnight stay in hospital so that when the drug has done what it needs to do, they then give folinic acid (not folic acid) which ensures that the rest of the body does not endure an overdose.
Accordingly it has been done for years and this man worked at the Dana Cancer hospital, Boston where it is used. See link:
http://www.dana-farber.net/
Apparently the treatment is given every 2 weeks, 8 cycles in all.
Possible links when I typed in "Methotrexate Blood Brain" on the Internet were the following:
http://www.springerlink.com/app/home/contribution.asp?wasp=flmhnmwhxhrd367rvvtk&referrer=parent&backto=issue,15,15;journal,74,157;linkingpublicati onresults,id:100473,1
This link was also interesting and referred to other drugs that cross the blood brain barrier:
http://www.virtualtrials.com/levin1.cfm?printer=Y
This is another GOOD one and refers to the Boston hospital. Apparently it was developed by Dr. Isaac Djerassi:
http://www.iptmd.com/new_page_9.htm
Hope this helps and good luck.
Elaine