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Old Today, 07:52 AM   #41
Senior Member
Join Date: Oct 2013
Posts: 323
Re: Treatment after Kadcyla?


My wife's daughter is visiting from Texas with the grandkids. Ill have to wait until Wednesday to call Genentech. The point is, the dose of Herceptin in Kadcyla is sufficient to
inhibit Her2 Neu protein even though it is lower (3.6mg/kg every 21 days rather than 6mg/kg every 21 days. Ill find out why but its purely an intellectual exercise. Perhaps the chemo attached to the Herceptin in the Kadcyla molecule makes the drug bind more tightly to the Her2neu protein receptor. Im intellectually curious but its not clinically importantapparently. Whoever told you the Herceptin (Trastuzumab) in the Kadcyla molecule is just a carrier for the chemo seems to be incorrect. I printed a long article about Kadcyla and it states again and again that the Herceptin part is active

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Old Today, 11:12 AM   #42
Senior Member
Join Date: Mar 2014
Location: UK
Posts: 515
Re: Treatment after Kadcyla?

Hi Paul
Interesting! It was my Oncologist that told me it was only a carrier.

Thanks for doing this Paul!

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