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03-16-2015, 07:12 PM
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#1
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Senior Member
Join Date: Oct 2005
Location: New Jersey
Posts: 3,154
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Study explains control of cell metabolism in breast cancer
__________________
Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
Started Femara Sept. 2006
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03-17-2015, 12:41 AM
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#2
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Senior Member
Join Date: Sep 2005
Location: france
Posts: 1,648
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Re: Study explains control of cell metabolism in breast cancer
thanks for posting this and the other articles.
__________________
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03-18-2015, 09:58 AM
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#3
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Senior Member
Join Date: Sep 2005
Location: Alaska
Posts: 2,018
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Re: Study explains control of cell metabolism in breast cancer
I wonder if the glutamine concept works well only with a taxane, or whether it would be meaningful for any other treatments.
I also wonder if there is any relationship they could identify as a precondition shared by that 30%, that isn't common among the others.
__________________
Dx 2002 age 51
bc for granny, aunt, cousin, sister, mother.
ER+/PR+/HER2+++, grade 3
IDC 1.9 cm, some DCIS, Stage 1, Grade 3
Lumpectomy, CAFx6 (no blood boosters), IMRT rads, 1 3/4 yr tamoxifen
Rads necrosis
BRCA 1 & 2 negative
Trials: Early detection OVCA; 2004 low-dose testosterone for bc survivors
Diet: Primarily vegetarian organic; metformin (no diabetes), vitamin D3
Exercise: 7 days a week, 1 hr/day
No trastuzumab, no taxane, no AI
NED
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03-18-2015, 01:51 PM
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#4
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Senior Member
Join Date: Oct 2005
Location: New Jersey
Posts: 3,154
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Re: Study explains control of cell metabolism in breast cancer
The article is stating that the proteins that carry the glutamate are broken down so the tumor has an insufficient supply of glutamate. The article is on the research on Taxanes only, not other drugs.
It says specifically taxanes, so therefore, until someone does the research on other drugs that question can't be answered. Since the main mechanism of Taxane drugs is to inhibit the process of cell division and it is one of the most popular chemo drugs, that is most likely why they started with the taxanes.
Again, everybody has different levels of amino acids and proteins and sometimes you cannot see any manifestation of those interactions among the cells. Basically you may have certain levels but you see no pre condition.
There are no real answers to your questions. I would gather it would demand further research.
jean
__________________
Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
Started Femara Sept. 2006
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03-18-2015, 02:04 PM
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#5
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Senior Member
Join Date: Sep 2005
Location: Alaska
Posts: 2,018
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Re: Study explains control of cell metabolism in breast cancer
However, because of the required blanket therapy with chemo, the question arises as to whether the group of 30% are those who had a taxane and for whom chemo was not necessary in the first place.
The above comment is entirely speculation, not fact, and is posed only as a result of the uncertainty created by blanket therapies.
__________________
Dx 2002 age 51
bc for granny, aunt, cousin, sister, mother.
ER+/PR+/HER2+++, grade 3
IDC 1.9 cm, some DCIS, Stage 1, Grade 3
Lumpectomy, CAFx6 (no blood boosters), IMRT rads, 1 3/4 yr tamoxifen
Rads necrosis
BRCA 1 & 2 negative
Trials: Early detection OVCA; 2004 low-dose testosterone for bc survivors
Diet: Primarily vegetarian organic; metformin (no diabetes), vitamin D3
Exercise: 7 days a week, 1 hr/day
No trastuzumab, no taxane, no AI
NED
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03-18-2015, 07:40 PM
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#6
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Senior Member
Join Date: Oct 2005
Location: New Jersey
Posts: 3,154
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Re: Study explains control of cell metabolism in breast cancer
...you have posed a speculative question to which their is not an answer as that would require additional research.
Also, it clearly states in the study that the research states,
"Not all tumors are equipped to respond to paclitaxel therapy," so therefore, the research does know that everyone will not respond.
You are going in the same circle. Nothing, Nothing at this time in research or medicine is 100%
It is research not a cure .....just yet.
__________________
Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
Started Femara Sept. 2006
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