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12-02-2011, 03:47 PM
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#1
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Senior Member
Join Date: Sep 2005
Location: Alaska
Posts: 2,018
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Metformin and the mitochondria
__________________
Dx 2002 age 51
bc for granny, aunt, cousin, sister, mother.
ER+/PR+/HER2+++, grade 3
IDC 1.9 cm, some DCIS, Stage 1, Grade 3
Lumpectomy, CAFx6 (no blood boosters), IMRT rads, 1 3/4 yr tamoxifen
Rads necrosis
BRCA 1 & 2 negative
Trials: Early detection OVCA; 2004 low-dose testosterone for bc survivors
Diet: Primarily vegetarian organic; metformin (no diabetes), vitamin D3
Exercise: 7 days a week, 1 hr/day
No trastuzumab, no taxane, no AI
NED
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12-02-2011, 05:42 PM
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#2
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Senior Member
Join Date: Jan 2008
Location: "Love never fails."
Posts: 5,808
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Re: Metformin and the mitochondria
Thanks for posting this. Glad there's finally some confirmation.
__________________
Jackie07
http://www.kevinmd.com/blog/2011/06/doctors-letter-patient-newly-diagnosed-cancer.html
http://www.asco.org/ASCOv2/MultiMedi...=114&trackID=2
NICU 4.4 LB
Erythema Nodosum 85
Life-long Central Neurocytoma 4x5x6.5 cm 23 hrs 62090 semi-coma 10 d PT OT ST 30 d
3 Infertility tmts 99 > 3 u. fibroids > Pills
CN 3 GKRS 52301
IDC 1.2 cm Her2 +++ ER 5% R. Lmptmy SLNB+1 71703 6 FEC 33 R Tamoxifen
Recc IIB 2.5 cm Bi-L Mast 61407 2/9 nds PET
6 TCH Cellulitis - Lymphedema - compression sleeve & glove
H w x 4 MUGA 51 D, J 49 M
Diastasis recti
Tamoxifen B. scan
Irrtbl bowel 1'09
Colonoscopy 313
BRCA1 V1247I
hptc hemangioma
Vertigo
GI - > yogurt
hysterectomy/oophorectomy 011410
Exemestane 25 mg tab 102912 ~ 101016 stopped due to r. hip/l.thigh pain after long walk
DEXA 1/13
1-2016 lesions in liver largest 9mm & 1.3 cm onco. says not cancer.
3-11 Appendectomy - visually O.K., a lot of puss. Final path result - not cancer.
Start Vitamin D3 and Calcium supplement （600mg x2)
10-10 Stopped Exemestane due to r. hip/l.thigh pain OKed by Onco 11-08-2016
7-23-2018 9 mm groundglass nodule within the right lower lobe with indolent behavior. Due to possible adenocarcinoma, Recommend annual surveilence.
7-10-2019 CT to check lung nodule.
1-10-2020 8mm stable nodule on R Lung, two 6mm new ones on L Lung, a possible lymph node involvement in inter fissule.
"I WANT TO BE AN OUTRAGEOUS OLD WOMAN WHO NEVER GETS CALLED AN OLD LADY. I WANT TO GET SHARP EDGED & EARTH COLORED, TILL I FADE AWAY FROM PURE JOY." Irene from Tampa
Advocacy is a passion .. not a pastime - Joe
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12-02-2011, 09:22 PM
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#3
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Senior Member
Join Date: Feb 2008
Location: South East Wisconsin
Posts: 3,431
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Re: Metformin and the mitochondria
Good news but frustratingly slow progress in legitimizing this relatively safe and cheap drug as at least a companion to standard treatment.
Other research shows metformin use can prevent ovarian cancer by 40%. Get on with it!
And of course..no good news is complete without a hugely misleading headline:
A new discovery that cures breast cancer |
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12-02-2011, 10:54 PM
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#4
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Senior Member
Join Date: Oct 2008
Posts: 88
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Re: Metformin and the mitochondria
This is great news - and something an NP in Canada recommended to me about 5 months ago. I'm gonna hold off for now, but GREAT to hear it's looking like something great to use!
Awesome - Kim
__________________
------------------------------
Dx Stage 3C 2005, triple +, tons of lymph nodes as well. FEC, surgery, TCH, rads, herceptin 1 year. And, Aromasin.
2007 - recurrence to medistinal lymph node, Abraxene and Herceptin - took it down 50%
2008 - on Arimidex/Herceptin - stable lymph node.
2009 - stable on Arimidex/Herceptin
2010 - lymph node progression and liver mets.
2010 - went on Gemzar, Navelbine, Herceptin - Navelbine and Herceptin took liver mets down. lymph node slightly progressed.
2010 - did Xeloda & Tykerb - MAJOR progression in liver in only 6 weeks.
Dec 2010 - present - Ixempra/Avastin/Herceptin/Fasoldex - regressing
June 2012 - chemo break
Sept 19, 2012 - start t-dm1. Chose this over going back on Ixempra.
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12-03-2011, 05:13 AM
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#5
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Senior Member
Join Date: Feb 2009
Posts: 1,526
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Re: Metformin and the mitochondria
Great news that Rich has been telling us about for ages.
I have just heard that they are looking at using metformin in a stage 1 trial at my centre. Will post if I find out more.
Ellie
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12-05-2011, 06:17 PM
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#6
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Senior Member
Join Date: Sep 2005
Location: Alaska
Posts: 2,018
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Re: Metformin and the mitochondria
__________________
Dx 2002 age 51
bc for granny, aunt, cousin, sister, mother.
ER+/PR+/HER2+++, grade 3
IDC 1.9 cm, some DCIS, Stage 1, Grade 3
Lumpectomy, CAFx6 (no blood boosters), IMRT rads, 1 3/4 yr tamoxifen
Rads necrosis
BRCA 1 & 2 negative
Trials: Early detection OVCA; 2004 low-dose testosterone for bc survivors
Diet: Primarily vegetarian organic; metformin (no diabetes), vitamin D3
Exercise: 7 days a week, 1 hr/day
No trastuzumab, no taxane, no AI
NED
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12-05-2011, 09:19 PM
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#7
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Senior Member
Join Date: May 2006
Posts: 3,142
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Re: Metformin and the mitochondria
My naturopath came across an article about Metformin and cancer and copied it for me to give my M. D. I readthe article before I passed it on. Metformin sounds promising.
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12-06-2011, 10:15 AM
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#8
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Junior Member
Join Date: Dec 2011
Posts: 3
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Re: Metformin and the mitochondria
There is currently a phase three clinical trial running on this. I'm trying to get more information as it's not at my cancer center. My oncologist decided not to run the trial because of concerns about the health impacts of using metformin in women without diabetes. Has anyone started the trial? I'm wondering how it's going.
I don't even know if I'm eligible, as I'm more than one year from dx and surgery.
Here's the link:
http://clinicaltrials.gov/ct2/show/NCT01101438 |
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