Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastases)

[marvass]

Paul, you did local radiation before starting IT herceptin, we did not. On small tumors it worked but not on the 2cm edema. Otherwise IT herceptin cleared over 10 tumors of 7mm or less.

Topotecan might have helped too, but I think that not doing radiation on the edema for such a lengthy period was a big mistake and Carol paid the price! But it looks as though the radiation now cleared the edema for we are at 1mg steroid only going to zero this week. Next follows an MRI and most probably we restart IT herceptin by end of next month.

Thanks for all your help and support Paul and wish you and Nina all the best.

Thank you Denise for you support.

Regards
Mario