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Old 09-25-2014, 04:39 PM   #1
Lani
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Join Date: Mar 2006
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Thumbs up putting pre-metastatic cancer cells on a strict diet to prevent them "leaving home"

Cancer Cells Adapt Energy Needs to Spread Illness to Other Organs
[MD Anderson Cancer Center]


Want to understand why cancer cells metastasize? Think of Sparta.

Ancient Greek warriors were fed a special diet that better prepared them for the demands of battle on distant fields. Cancer cells that metastasize may do the same thing according to a new study revealing previously unknown differences between cancer cells that continue to grow at the original tumor site, and those that travel to other organs.

Given that a cancer cell's unyielding ability to metastasize is the primary cause of cancer-related death, understanding how they successfully migrate can be lifesaving.

Scientists at The University of Texas MD Anderson Cancer Center have found that cancer cells traveling to other sites have different energy needs from their "stay-at-home" siblings which continue to proliferate at the original tumor site. The study results are in the Sept. 21 online edition of Nature Cell Biology.

The reason may lie with the protein, PGC-1α, a type of transcription co-activator crucial to regulation of cellular metabolism. PGC-1α appears to play a role in how cancer cells are able to acquire unique energy sources that allow them to travel and spread cancer in the body.

"New therapy strategies are beginning to focus on the unique vulnerabilities of cancer cell metabolism. Determining the metabolic requirements of invasive cancer cells could be of therapeutic value," said Valerie LeBleu, Ph.D., assistant professor of cancer biology at MD Anderson and lead author of the Nature Cell Biology paper. "We found that invading cancer cells rely on mitochondria during their transition to other cancer sites."

Cancer cells use PGC-1α to stimulate the growth of new mitochondria, the cell's "power plants" that generate ATP, an energy "currency" used by cells to grow. Metastasizing cells also rely on PGC-1α for a process known as oxidative phosphorylation that boosts ATP during the cell's journey to other sites. If mitochondria is the kitchen, then PGC-1α is the chef, ATP the entreĆ© and oxidative phosphorylation a key ingredient. This overall process, mitochondria respiration, allows some cancer cells to harness the required energy to survive the hostile journey through tumor and normal tissue, blood vessels, and entry into new organs.

In other words, some cancer cells are programmed to eat at home, while others have a special diet that allows them to travel to other sites. If there was a therapeutic way to stop the migrating cells from packing a lunch ahead of time, it could potentially halt their journey. Suppressing PGC-1α appears to accomplish this.

"The most dangerous cancer cells are the ones that can efficiently move and find a new home," said Raghu Kalluri, M.D., Ph.D., chair of cancer biology and an investigator on the study. "The study revealed a strong correlation between PGC-1α expression in invasive cancer cells and the formation of distant metastases in breast cancer patients."

Other co-authors included Joyce O'Connell, Ph.D., and John Asara, Ph.D., Beth Israel Deaconess Medical Center, Boson, Ma.; Karina Gonzalez Herrera, Ph.D., and Marcia Haigis, Ph.D., Harvard Medical School, Boston, Ma.; Harriet Wikman, Ph.D., and Klaus Pantel, M.D., University Medical Center Hamburg-Eppendorf, Hamburg, Germany; and Fernanda Machada de Carvalho, Ph.D., Aline Damascena, Ludmilla Thome Domingos Chinen, Ph.D., and Rafael Rocha, Ph.D., Camargo Cancer Center, Sao Paulo, Brazil.

The study was funded by the Cancer Prevention and Research Institute of Texas, MD Anderson Cancer Center, the Department of Defense Cancer Research Predoctoral Traineeship Award (W81XWH-09-1-0008). Kalluri is also funded by the National Institutes of Health (CA 125550, CA 1555370, CA 151925, DK081576, DK055001, CA12096405, and CA00651646).

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ABSTRACT: PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis
[Nature Cell Biology;]

Cancer cells can divert metabolites into anabolic pathways to support their rapid proliferation and to accumulate the cellular building blocks required for tumour growth. However, the specific bioenergetic profile of invasive and metastatic cancer cells is unknown. Here we report that migratory/invasive cancer cells specifically favour mitochondrial respiration and increased ?ATP production. Invasive cancer cells use the transcription coactivator peroxisome ?proliferator-activated receptor gamma, coactivator 1 alpha (?PPARGC1A, also known as ?PGC-1α) to enhance oxidative phosphorylation, mitochondrial biogenesis and the ?oxygen consumption rate. Clinical analysis of human invasive breast cancers revealed a strong correlation between ?PGC-1α expression in invasive cancer cells and the formation of distant metastases. Silencing of ?PGC-1α in cancer cells suspended their invasive potential and attenuated metastasis without affecting proliferation, primary tumour growth or the epithelial-to-mesenchymal program. Inherent genetics of cancer cells can determine the transcriptome framework associated with invasion and metastasis, and mitochondrial biogenesis and respiration induced by ?PGC-1α are also essential for functional motility of cancer cells and metastasis.
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Old 09-25-2014, 10:23 PM   #2
Saygoon
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Location: Hot Springs, South Dakota
Posts: 158
Re: putting pre-metastatic cancer cells on a strict diet to prevent them "leaving hom

Interesting - anxious to see what they do with this info
__________________
Paula T. (saygoon means dog, yes I am Native)
DX March 2012
Stage IV w/ 5 bone mets to spine 2 on ribs
Herceptin, Zometa, Taxotere and Anasterole and of course radiation
2/14/2014 2 mets on pelvic bone
Stop Anasterole continue on Herceptin and Zometa start radiation (again)
2/24/2014 start T-DM1 continue Herceptin and Zometa
4/28 more radiation that brings total to 5 (10 days ea) - I think I will soon glow in the dark....
6/01/2014 Great news! Rib mets gone, 4 of 5 spine mets showing new bone growth and pelvic mets shrinking.
8/28/2014 T11 on spine is being stubborn started Perjeta, Herceptin, Zometa and Taxol - goodbye hair!
9/04/2014 Tomo therapy - pain finally gone
1/3/2015 - starting New Year out as still stable. Feeling positive
2/23/2015 - problems with left leg, bone met flaring up - MORE radiation Whew!
2/24/2015 Stress fracture in right side of pelvic - (great just great) back to wheelchair then walker then.....
2/26/2015 Off Taxol!! Still on Perjeta, Herceptin and Hormone Blocker starting to feel a little more human.
4/10/2015 Cancer has spread to spinal fluid - not sure where I go from here
6/29/2015 Omaya Port placed,begin IT Herceptin on 7/7/2015
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