HAIR dye identified in compromising position! (holding onto DNA in breast cells)

[Lani]

1: Arch Biochem Biophys. 2007 Jun 8; [Epub ahead of print]
Hair dye use, meat intake, and tobacco exposure and presence of carcinogen-DNA adducts in exfoliated breast ductal epithelial cells.

Ambrosone CB, Abrams SM, Gorlewska-Roberts K, Kadlubar FF.
Division of Epidemiology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
Diet and environmental exposures to aromatic and heterocyclic amines, and polycyclic aromatic hydrocarbons, are thought to be etiologic factors for breast cancer risk. In this study, we chose to quantify the major DNA adduct derived from one member of each of these classes of carcinogens in epithelial cell DNA isolated from human breast milk. Appreciable adducts were detected for each class, namely 2-amino-6-phenylimidazo[4,5-b]pyridine (PhIP), 4-aminobiphenyl (ABP) and benzo[a]pyrene. The effect of several metabolic genotypes on adduct levels were also investigated and higher PhIP and ABP adducts were associated with the rapid NAT2 and/or rapid NAT1 genotypes. The presence of ABP adducts was also significantly associated with the use of hair coloring products (OR=11.2, 95% CI=1.1-109.2) but not tobacco usage. These data indicate that women are exposed to several classes of dietary and environmental carcinogens and that metabolic genotype can be a susceptibility factor.
PMID: 17601487 [PubMed - as supplied by publisher]

[pennyvphoto]

do you know which hair dyes pose a risk?

[Lani]

...ABP-DNA adduct levels found in these 18 sam-
ples according to use of hair dyes and illustrates that of the
18 samples containing ABP-DNA adducts, 14 (78%)
reported using hair dye in the past year and 8 (44%) were
minority (non-white) women.
To further explore the relationship between hair dye
use and DNA adduct levels, we examined the associa-
tions between other measures of hair dye use, namely
frequency of use, type of dye used, and color used,
and presence of ABP adducts. Table 1 shows adjusted
odds ratios (ORs) and 95% confidence intervals (CIs)
for the association between the presence of ABP-DNA
adducts and measures of hair dye use. Women who
reported using hair dye in the past year were 8 times
more likely to have ABP adducts present, compared to
those who did not use hair dye though this associated
was not statistically significant. Also, hair dye use at
least once in the past 6 months was associated with pres-
ence of ABP adducts (OR = 11.2, 95% CI = 1.1–109.2).
This relationship between hair dye use and ABP adducts
did not persist when examining the type of hair dye
used. Use of either temporary or permanent hair dye
was not associated with the presence of ABP adducts.
Finally, when distinguishing between color of hair dye
used, use of light (blonde or light brown) hair dye colors
compared with non-use was associated with presence of
ABP adducts (OR = 18.1, 95% CI = 1.5–226.8), while
use of medium and dark hair colors were not associated
with ABP adducts. While the small sample sizes in these
analyses lead to wide confidence intervals, the overall
picture indicates an association between presence of
ABP adducts and hair dye use.

So maybe it isn't always better to be blonde!