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09-04-2007, 02:22 PM
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#1
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Senior Member
Join Date: Aug 2001
Location: Oregon
Posts: 1,756
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Starting new regimen Thursday
Tykerb/Abraxane have run their course for me; my skin nodules continue to grow in the right chest wall and so my onc had me stop Tykerb/Abraxane last week. This Thursday I'll start back on weekly Herceptin, along with Taxotere which I've not had, and daily Xeloda which I have had but the dose is being upped to 1,000 mg twice daily.
My axilla nodes shrank on T/A, and I have a scan tomorrow to check those and make sure there's no spread elsewhere. Will let you know how I do.
I haven't been posting as much lately, as I just don't seem to have much energy, and that has me a bit worried, so I hope this new regimen will turn the tide for me.
Keeping you all in my thoughts and prayers.
<3 Lolly
__________________
Sept.'99 - Dx.Stage IIIB, IDC ER/PR-, HER2+++ by IHC, confirmed '04 by FISH. Left MRM, AC x's 4, Taxol x's 4, 33 Rads, finishing Tx May 2000. Jan.'01 - local/regional recurrence, Stage IV. Herceptin/Navelbine weekly till NED August 2001, then maintenance Herceptin. Right Mast. April 2002. Local/Regional recurrence April '04, Herceptin plus/minus chemo until May '07. Gemzar added from Feb.'07-April '07; Tykerb/Abraxane until August '07, back on Herceptin plus Taxotere and Xeloda Sept. '07. Stopped T/X Nov. '07, stopped Herceptin Dec. '07, started Avastin/Taxol/Carboplatin Dec. '07. Progression in chest skin, stopped TAC March '03, started radiation.
Herceptin has served as the "Backbone" of my treatment strategy for over 6 years, giving me great quality of life. In 2005, I was privileged to participate in the University of Washington/Seattle HER2 Vaccine Trial.
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09-04-2007, 02:41 PM
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#2
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Senior Member
Join Date: Oct 2005
Location: Saratoga Springs New York
Posts: 136
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Hi Lolly, I'm sorry to hear that you are having progession. You have always been a big inspiration to me since the get go. I know you will give it your best and come out strong. Try to remember to keep smiling and stay positive. Taxotere worked great for me three years ago. I also got about 3 years on Herceptin. I recently had my first reoccurence. I had to stop Herceptin and got on Tykerb/ Xeloda. When I see all you have been through in your signature it gives me hope that I still have a long way to go before options run out. Make sure you keep us posted on how you are doing. Good luck with the Taxotere. Sally
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09-04-2007, 03:25 PM
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#3
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Senior Member
Join Date: Feb 2006
Location: Acworth, GA
Posts: 2,104
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Lolly,
I'm so sorry to hear that you are having progression in the skin nodules. I know what you mean about not having any energy as that's my main problem now. I had Taxatore neoadjunctly and it shrank my tumor from over 5cm to almost nothing. I'm hoping that it will do the trick for you. You'll be in my prayers.
__________________
Kate
Stage IIIC Diagnosed Oct 25, 2005 (age 58)
ER/PR-, HER2+++, grade 3, Ploidy/DNA index: Aneuploid/1.61, S-phase: 24.2%
Neoadjunct chemo: 4 A/C; 4 Taxatore
Bilateral mastectomy June 8, 2006
14 of 26 nodes positive
Herceptin June 22, 2006 - April 20, 2007
Radiation (X35) July 24-September 11, 2006
BRCA1/BRCA2 negative
Stage IV lung mets July 13, 2007 - TCH
Single brain met - August 6, 2007 -CyberKnife
Oct 2007 - clear brain MRI and lung mets shrinking.
March 2008 lung met progression, brain still clear - begin Tykerb/Xeloda/Ixempra
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09-04-2007, 03:27 PM
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#4
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Senior Member
Join Date: Aug 2006
Location: Sheboygan, WI
Posts: 2,582
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Sending hugs to you Lolly and also prayers that your new regimen will do what needs to be done.
Dang this cancer. Why does it have to be so nasty? Why can't it react to treatment the way we want it too? Why does it have to be so sneaky and cause such havoc to our lives? I'm sorry.........I'm "thinking" out loud and needed to say it.
Once again, sending hugs, love and prayers to you Lolly.
Mary Jo
__________________
"Be still and know that I am God." Psalm 46:10
Dx. 6/24/05 age 45 Right Breast IDC ER/PR. Neg., - Her2+++ RB Mast. - 7/28/05 - 4 cm. tumor Margins clear - 1 microscopic cell 1 sent. node No Vasucular Invasion 4 DD A/C - 4 DD Taxol & Herceptin 1 full year of Herceptin received every 3 weeks 28 rads prophylactic Mast. 3/2/06
17 Years NED
<>< Romans 8:28
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09-04-2007, 03:49 PM
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#5
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Senior Member
Join Date: Oct 2005
Location: TAMPA, FL
Posts: 568
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Dang It Is Right..
Except I would not mind using a stronger word
just when we start getting "a wee bit comfortable" with where we are...
boom, here we go again. I can certainly relate and I am so sorry but Lolly you will rally once again. You just stay strong my friend
I wish you the best on your next regimen and let us know how your test turn out and how you are doing please.
__________________
Irene from Tampa
1996 - INFILT DUCTAL CAR.W/ LYMPH NODE INVOLVEMENT. ADRIA/CYTOXIN/5FU
1999 - RECURR. TO AUXILA AND 2 TUMORS IN LIVER
TREAT: STEM CELL REPLACEMENT/HERCEPTIN.
2002 - RECUR TO LIVER
TREAT: NAVELBINE, THEN GEMZAR, THEN XELODA.
2004 - TUMORS STILL IN LIVER
TREAT: RFA TO LIVER
STABLE UNTIL
2004 - TUMOR PROGRESSION IN LIVER.
TREAT: RESECT HALF OF LIVER.
2005 - RECURR TO LYMPH NODE OUTSIDE OF LIVER.
TREAT: TAXOL/CARPO/HERCEPTIN. FAILED ON
THIS TRIO. STARTED ON ABRAXANE.
2006 - PROGRESS WITH 2ND TUMOR GROWTH.
TREAT: AUG. BEGAN ON TYKERB/XELODA
TRIAL. CONSIDERED STABLE TO DATE.
2007 - TAKEN OFF OF TYKERB/XELODA TRIAL DUE TO
PROGRESS STARTING TYKERB/AVASTIN.
NOV 2007 - SCANS SHOW PROGRESS TUMOR GROWTH
IN ABDOM. AND TWO NEW TUMORS IN NECK AREA.
BEGAN HERCEPTIN/AVASTIN/TAXOTERE
Feb 08 - Ixempra/Xeloda
June 08 - Her/DM1 trial
"I WANT TO BE AN OUTRAGEOUS OLD WOMAN WHO NEVER GETS CALLED AN OLD LADY. I WANT TO GET SHARP EDGED & EARTH COLORED, TILL I FADE AWAY FROM PURE JOY."
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09-04-2007, 03:55 PM
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#6
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Senior Member
Join Date: Jul 2007
Posts: 43
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will keep you in my prayers. may GOD give you strength and courage during this time . with that shining smile of yours i know your days will be filled with sunshine and GOD blessings dorinda
__________________
nov 2006 dx. with bc. 3 tumors removed from left breast lumpectomy done. her2 postive er+pr-. scans showed extensive spine mets(to many to count) ,3 tumors on left rib,one tumor on skull and 3 tumors on liver. stage IV from get go. dec.2006 started chemo taxol and herceptine wkly. zometa monthly. rescanned in march 2007, liver tumors shrinking a little. bones to early to tell but pain is gone in my back. rescanned in june 2007. liver mets gone, bone scan looking better but still alot in my spine. still on taxol and herceptine. zometa monthly. rescanned in august due to ca 2729 going up. liver still good , mets in ribs and skull gone but multiple areas still on lumbar and sacrum. mri of brain august 07 negative for mets.I AM BELIEVLING GOD FOR MY HEALING.
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09-04-2007, 05:26 PM
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#7
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Senior Member
Join Date: Sep 2005
Location: Stockton, NJ
Posts: 4,179
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I will keep you in my thoughts Lolly. I hope Taxotere thrashes the cancer totally away and allows you a much deserved chemo break.
__________________
Kind regards
Becky
Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Prolia every 6 months for osteopenia
NED 18 years!
Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
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09-04-2007, 05:27 PM
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#8
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Senior Member
Join Date: Jan 2007
Location: Thornhill, Ontario
Canada
Posts: 2,320
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Hi Lolly,
Sorry to hear about your progression, but Taxotere is an awesome drug - hoping it beats those nasty cancer nodes down to nothing.
all the best,
caya
__________________
ER90%+/PR 50%+/HER 2+
1.7 cm and 1.0 cm.
Stage 1, grade 2, Node Negative (16 nodes tested)
MRM Dec.18/06
3 x FEC, 3 x Taxotere
Herceptin - every 3 weeks for a year, finished May 8/08
Tamoxifen - 2 1/2 years
Femara - Jan. 1, 2010 - July 18, 2012
BRCA1/BRCA2 Negative
Dignosed 10/16/06, age 48 , premenopausal
Mild lymphedema diagnosed June 2009 - breast surgeon and lymph. therapist think it's completely reversible - hope so.
Reclast infusion January 2012
Oopherectomy October 2013
15 Years NED!!
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09-04-2007, 05:39 PM
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#9
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Senior Member
Join Date: Nov 2005
Location: Northern Calif.
Posts: 981
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Hi Lolly,
I am sorry that those nasty skin nodules aren't going away. I am hopeful that the taxotere added to your new regime will be just what is needed to blast those suckers into orbit. You are in my prayers now for comfort, strength and peace as you begin your new tx combo.
Love and Prayers,
Lexi
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09-04-2007, 05:42 PM
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#10
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Senior Member
Join Date: Nov 2005
Location: Lincoln, Rhode Island
Posts: 371
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I am sos orry you have to go through this, and you are in my thoughts and prayers that this new treatment kick butt!
__________________
Love and Hope
Karen
IDC
DX 1998 STAGE I ER+/ PR+
AC CHEMO TILL FEB 1999
Tamxofin till 2001
2001 exstensive liver mets and mets to lungs
Started weekly taxol
Jan 2002 found out I was strongly HER2POS+++ started herceptin continued with taxol and herceptin till June 2002 then from June 2002 till Jan 2005 just herceptin and Arimidex
2005 Navelbine herceptin had RFA Then back on taxol with herceptin
April 2006 progression again went on clinical trial with tykrerb/herceptin progressed on the started Xeloda/ herceptin
Feb 2007 started Doxil
August 2007 Taxotere,Carboplatin and Herceptin exstensive mets to liver and pancreas
October 2007 Had to stop Carboplatin due to sever allergic reaction
Jan 2008
Stopped Taxotere due to progression now on Gemzar and Herceptin
March 2008 Starting Carboplatin, Abraxane, and Herceptin.
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09-04-2007, 05:59 PM
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#11
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Senior Member
Join Date: Sep 2005
Location: South Dakota.
Posts: 621
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Oh my, I am sorry...we'll have you in our prayers... hoping the new meds will bring you to NED.
__________________
Blessings and Peace,
Barbara
DX Oct 02 @ age 52 Stage 2B Grade 3 Mastectomy
"at least" 4.5 cm IDC 1+node ER+61% /PR-
Assiciated Intraductual component with Comedo Necrosis
Her2+ FISH8.6 IHC 2+
5 1/2 CEF Arimidex
Celebrex 400mg daily for 13 months
Prophylactic mastectomy
Estradiol #: 13
PTEN positive, "late" Herceptin (26 months after chemo)
Oct 05: Actonel for osteopenia from Arimidex.
May 08: Replaced Actonel with Zometa . Taking every 6
months.
Accepting the gift of life, I give thanks for it and live it in fullness.
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09-04-2007, 06:01 PM
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#12
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Senior Member
Join Date: Dec 2006
Posts: 63
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Wish you the best with the new combo. It's good to hear from you.
Hugs,
Anne
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09-04-2007, 06:33 PM
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#13
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Senior Member
Join Date: Sep 2005
Location: Mountains of Virginia
Posts: 2,267
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Lolly,
Keeping you in my thoughts and prayers that Taxotere will do the job.
________
DEMIDA cam
Last edited by sassy; 08-22-2011 at 09:29 AM..
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09-04-2007, 06:56 PM
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#14
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Senior Member
Join Date: Jul 2007
Location: Northern California
Posts: 764
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Lolly,
Wishing you renewed strength as you start new treatment. Sending positive, healing toughts and prayers.
__________________
DX 02/01/07
2.5 cm, Er/Pr-, Her2+++
18/20 Nodes
03/07 CT & Bone scan - Clear
AC x 4, Taxol x 4, Added Herceptin
Radiation until 09/07
Herceptin every 3 weeks until 06/08
01/10/08 local recurrence -IBC
01/28/08 CT & Brain MRI - clear
02/08 - Navelbine & Herceptin
05/08 -MRM
05/08 - Gemzar & Herceptin - didn't work
09/08 - Hyperthermia rads
03/09 - Tykerb/Xeloda
05/10 - Tram flap to fix wound
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09-04-2007, 07:33 PM
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#15
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Senior Member
Join Date: Jun 2006
Location: South Florida
Posts: 477
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Lolly,
Thinking of you and sending extra prayers.
Love, Hope, and Peace,
Carolyn
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09-04-2007, 08:07 PM
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#16
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Senior Member
Join Date: Sep 2005
Posts: 556
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Lolly,
You are in my thoughts. Sending all the positive energy for the new regimen to wipe out the remaining mets.
Julie
__________________
Diagnosed in Sept 2004 while pregnant with the second child. Stage 3b, tumor 4.5cm, 4 auxillary and supraclav node positive. Her2+++ FISH 9.4 and er-,pr-.
Had dose dense neoadjuvant AC,Taxol then mastectomy,radiation+xeloda+Herceptin.
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09-04-2007, 09:21 PM
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#17
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Senior Member
Join Date: Sep 2005
Location: Central Coast, CA
Posts: 3,207
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Well, I'll use a stronger word. POO.
Sorry to hear this one didn't completely slap it down - but you know that Taxotere/Herceptin is very synergistic and adding Xeloda to that I hope will get everything back in control quickly.
Take care of yourself, get plenty of rest.
On taxotere, don't forget about the frozen peas for your fingers and toes during the infusion!
Take care, keep us posted.
Much love
Chris
__________________
Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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09-04-2007, 09:23 PM
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#18
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Senior Member
Join Date: Dec 2006
Location: Oregon
Posts: 715
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Lolly,
Where are these bad monkeys coming from? I hope the Taxotere works well for you. I know you have a good doctor and that you are a determined survivor. I am just sorry that these nodules (noodles?) have not gone away yet. You will be in my thoughts and prayers on Thursday.
Hang in there, save your energy and keep the faith. You are an inspiration to all of us and we are behind you 100%.
All the best, Catherine
(oregon girls united against the bad monkeys)
__________________
Catherine
Found my own lump in the shower
April 2006 at the age of 58
Stage IIB, ER- PR- HER2+++ multi focal tumors, largest 2.3cm
Chemo first: AC/Taxol over 16 weeks
Bilateral mastectomy Sep 06
33 rads after the surgery
1 year of Herceptin completed Dec 07
15 years and no recurrence as of April 2021
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09-04-2007, 11:22 PM
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#19
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Senior Member
Join Date: Oct 2005
Location: San Francisco, CA
Posts: 96
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Hi Lolly,
I am sorry to hear that you are struggling with those nodules and the T/A stopped working. You are a survivor and will beat this beast (or bad monkeys :-)) away. Hang in there and hopefully your energy will return with this new combo. Good luck with your treatment Thursday. You will be in my thoughts and prayers.
Hugs,
Patricia
__________________
age 37 @ dx 7/21/05: IDC 1.5cm, grade III, Stage 1c, ER /PR+, HER2+,
7/29/05: Partial Mastectomy
dx 8/15/05: Papillary Thyroid Cancer
9/15/05: Total Thyroidectomy
A/C X 4 DD, 11 weekly Taxol + Herceptin, + 9 mos Herceptin Alone, 36x Rads, Lupron, Aromasin
7/29/07: 2 years NED :)
8/6/07 Oopherectomy (Lupron no more! :-)
Aromasin & Estring plus Synthroid and supplements
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09-04-2007, 11:44 PM
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#20
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Senior Member
Join Date: Sep 2005
Location: Vancouver, Canada
Posts: 329
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Dear Lolly,
You are in my thoughts and I wish the best for you my dear.
big hug,
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