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Old 02-27-2008, 10:40 AM   #1
Marlys
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Ouch! My fingertips are splitting.

Back in my early days here we all talked about the symptoms we had with Herceptin ie: "crusties, split fingertips and nails. Well, I finished Herceptin in July, 2006 and my fingers are killing me(not really). Has this happened to any of you? The only meds I'm taking that is cancer related is Arimidex. Any suggestions?
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Old 02-27-2008, 10:45 AM   #2
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Hi Marlys
I finished Herceptin in January 2007.
My fingernails grow a little bit and then
they peel off. They are not brittle, they
are weak and thin. I thought they would
get back to "normal" by now.
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2cm. Stage 2A, Grade 3
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Sept 7/05 Mastectomy
4 FAC, 4 Taxol, no radiation
1 year of Herceptin
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Old 02-27-2008, 01:39 PM   #3
Missyw
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Hi Marlys,

I am on Herceptin (indefinite) and Arimidex. I too, had problems with my nails. (I know I hate to complain about something so trivial, but it was a pain). Anyway I recently tried a product called "Rejuvacote". I bought it online but I have since learned it is available at certain Bed Bath and Beyond stores. I am not sure why it has worked when nothing else made a difference, but it has helped. I also use Avonoplex (a cuticle oil) at bedtime. Neither product is very expensive so maybe they are worht a try. Good luck.

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Old 02-27-2008, 01:57 PM   #4
MJo
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Yes. When I was on Herceptin my nails were soft and breaking all the time. One year after Herceptin they are back to normal. Worst was A/C. My nails turned black. Ugh. All better now.
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IDC, Stage I, Grade 2
Oncotype DX Score 32
Her2++ E+P+, Node Neg.
Lumpectomy 11/04/05 Clear Margins
3 Dose dense AC (Couldn't tolerate 4)
4 Dose dense Taxol & Herc. (Tolerated well)
36 weeks Herceptin (Could not complete one year due to decrease in MUGA score)
2 years of Arimidex, then three years of Femara
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Old 02-27-2008, 07:30 PM   #5
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Try putting a good coating of bag balm on your hands and then slipping some cotton gloves on. This has helped women on Xeloda, which can also cause the fingertips to crack.
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Old 02-28-2008, 09:55 AM   #6
Marlys
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Thanks everyone. I am off to the store for bag balm and Rejuvacoat. I am actually having to type this with the ring finger on my right hand because its the only one that doesn't hurt.
Love & hugs,
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Old 02-28-2008, 11:04 AM   #7
PinkGirl
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Sorry, I have to ask. Bag balm?????
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Dx Aug/05 at age 51
2cm. Stage 2A, Grade 3
ER+/PR-
Her2 +++

Sept 7/05 Mastectomy
4 FAC, 4 Taxol, no radiation
1 year of Herceptin
Tamoxifen for approx. 4 months,
Arimidex for 5 years
Prophylactic mastectomy June 22/09



" I yam what I yam." - Popeye

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Old 02-28-2008, 11:16 AM   #8
Believe51
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PinkGirl

This is a balm that they use for cows utters, it is amazing stuff and works wonders>>Believe51
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Old 02-28-2008, 11:22 AM   #9
Jeanette
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Bag balm.

Believe51, I do think it's udders. Course I could be wrong., Hugs, jeanette
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Old 02-28-2008, 04:49 PM   #10
rinaina
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I finished herceptin August 2007 and my fingernails and tips are just getting back in good shape so hang in there. Not sure about arimidex causing same with fingers.
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Dx:3/06 had a lumpectomy April 19, 2006
Her2+ er/pr- Stage I Grade 3 tumor size 1.4 cm, node negative
AC 4 dense doses
34 radiation treatments including booster doses
receiving herceptin every 3 weeks since late August 2006 for 12 months
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Old 02-28-2008, 08:10 PM   #11
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Marly, wish I could help on this one, but all I can think of is Madge, soaking her fingers in Palmolive in that old commercial. Jeanette, I'm sorry, but you are wrong. Believe 51 was correct when she commented that they use the balm for "cow utters". Jeanette, I know you're from Scotland, so there is a little bit of a language barrier, but I can help. (I'm Stewart, wife, Clark/Moffat from Prestwick area) In the early days of cow-milking, which began in this country in central Idaho, the winters were very harsh and long. Like Canada, the cow farmers in Idaho had only one week of spring, which they usually scheduled for the last week of August. Anyhow, the winters were so cold, that when the early morning cow-milking was to be done, the mothers and fathers would roust their young sons out of bed to go do the milking, and then they would sleep in a few more hours before the morning potato-digging. Often, the young sons would "mutter" in their sleep, "what the heck, I was sound asleep, don't wanna go milk a cow, me hands is cracked and bleedin'" The father would grab his switch and whip 'em out of bed yelling "don't give me your cow-mutters again, boy!" "But, Papa, me hands!" Then the father would smear some salve onto the hands of his son's cracked and sore hands to ease the pain for the milking. "Now get to milkin' you, you lousy cow-mutterers!" Over the years, the expression was shortened to "cow-utterers", and decades later, the expression was shortened, yet again, to "cow utters" and it became a common term in this country to refer to a milker of cows as a "cow utter", early in the 1850's it became a common practice for a milk-rancher to line up his cow utters before dawn and apply a soothing balm to their hands before the day's milking. (This early morning practice of applying balm to the hands of early American potato-diggers failed, as the potatoes they tried to dig slipped from their hands too easily) So, you see, Jeanette, Believe was correct. Love ya, Bill
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Old 02-28-2008, 08:59 PM   #12
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Bill -
Utterly fantastic.
You "crack" me up - maybe I'll coat myself with some Bag bog. I bet it's good for faces (comma)too.
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1996 cancer WTF?! 1.3 cm lumpectomy Er/Pr neg. Her2+ (20nodes NEGATIVE) did CMF + rads. NED.
2002 recurrence. Bilateral mastectomy w/TFL autologous recon. Then ACx2. Skin lymphatic rash. Taxotere w/Herceptin x4. Herceptin/Xeloda. Finally stops spreading.
2003 - Back to surgery, remove skin mets, and will have surgery one week later when pathology can confirm margins.
‘03 latisimus dorsi flap to remove skin mets. CLEAN MARGINS. Continue single agent Herceptin thru 4/04. NED.
‘04 '05 & 06 tiny recurrences - scar line. surgery to cut out. NED each time.
1/2006 Rads again, to scar line. NED.

3/07 Heartbreaking news - mets! lungs.sternum. Try Tykerb/Xeloda. Tykerb/Carbo/Gemzar. Switch Oncs.
12/07 Herceptin.Tykerb. Markers go stable.
2/8/08 gamma knife 13mm stupid brain met.
3/08 Herceptin/tykerb/avastin/zometa.
3/09 brain NED. Lungs STABLE.
4/09 attack sternum (10 daysPHOTONS.5 days ELECTRONS)
9/09 MARKERS normal!
3/10 PET/CT=manubrium intensely metabolically active but stable. NEDhead.
Wash out 5/10 for tdm1 but 6/10 CT STABLE, PET improving. Markers normal. Brain NED. Resume just Herceptin plus ZOMETA
Dec 2010 Brain NED, lungs/sternum stable. markers normal.
MAR 2011 stop Herceptin/allergy! Go back on Tykerb and switch to Xgeva.
May-Aug 2011 Tykerb Herceptin Xgeva.
Sept 2011 Tykerb, Herceptin, Zometa, Avastin.
April 2012 sketchy drug trial in NYC. 6 weeks later I’m NED!
OCT 2012 PET/CT shows a bunch of freakin’ progression. Back to LA and Herceptin.avastin.zometa.
12/20/12 add in PERJETA!
March 2013 – 5 YEARS POST continue HAPZ
APRIL 2013 - 6 yrs stage 4. "FAILED" PETscan on 4/2/13
May 2013: rePetted - improvement in lungs, left adrenal stable, right 6th rib inactive, (must be PERJETA avastin) sternum and L1 fruckin'worsen. Drop zometa. ADD Xgeva. Doc says get rads consultant for L1 and possible biopsy of L1. I say, no thanks, doc. Lets see what xgeva brings to the table first. It's summer.
June-August 2013HAPX Herceptin Avastin Perjeta xgeva.
Sept - now - on chemo hold for calming tummy we hope. Markers stable for 2 months.
Nov 2013 - Herceptin-Perjeta-Avastin-Xgeva (collageneous colitis, which explains tummy probs, added Entocort)
December '13 BRAIN MRI ned in da head.
Jan 2014: CONTINUING on HAPX…
FEB 2014 PetCT clinical “impression”: 1. newbie nodule - SUV 1.5 right apical nodule, mildly hypermetabolic “suggestive” of worsening neoplastic lesion. 2. moderate worsening of the sternum – SUV 5.6 from 3.8
3. increasing sclerosis & decreasing activity of L1 met “suggests” mild healing. (SUV 9.4 v 12.1 in May ‘13)
4. scattered lung nodules, up to 5mm in size = stable, no increased activity
5. other small scattered sclerotic lesions, one in right iliac and one in thoracic vertebral body similar in appearance to L1 without PET activity and not clearly pathologic
APRIL 2014 - 6 YRS POST GAMMA ZAP, 7 YRS MBC & 18 YEARS FROM ORIGINAL DX!
October 2014: hold avastin, continue HPX
Feb 2015 Cancer you lost. NEDHEAD 7 years post gamma zap miracle, 8 years ST4, +19 yrs original diagnosis.
Continue HPX. Adding back Avastin
Nov 2015 pet/ct is mixed result. L1 SUV is worse. Continue Herceptin/avastin/xgeva. Might revisit Perjeta for L1. Meantime going for rads consult for L1
December 2015 - brain stable. Continue Herceptin, Perjeta, Avastin and xgeva.
Jan 2016: 5 days, 20 grays, Rads to L1 and continue on HAPX. I’m trying to "save" TDM1 for next line. Hope the rads work to quiet L1. Sciatic pain extraordinaire :((
Markers drop post rads.
2/24/16 HAP plus X - markers are down
SCIATIC PAIN DEAL BREAKER.
3/23/16 Laminectomy w/coflex implant L4/5. NO MORE SCIATIC PAIN!!! Healing.
APRIL 2016 - 9 YRS MBC
July 2016 - continue HAP plus Xgeva.
DEC 2016 - PETCT: mets to sternum, lungs, L1 still about the same in size and PET activity. Markers not bad. Not making changes if I don't need to. Herceptin/Perjeta/Avastin/Xgeva
APRIL 2017 10 YEARS MBC
December 2017 - Progression - gonna switch it up
FEB 2018 - Kadcyla 3 cycles ---->progression :(
MAY30th - bronchoscopy, w/foundation1 - her2 enriched
Aug 27, 2018 - start clinical trial ZW25
JAN 2019 - ZW25 seems to be keeping me stable
APRIL 2019 - ONE DOZEN YEARS LIVING METASTATIC
MAY 2019 - progression back on herceptin add xeloda
JUNE 2019 - "6 mos average survival" LMD & CNS new single brain met - one zap during 5 days true beam SBRT to cord met
10/30/19 - stable brain and cord. progression lungs and bones. washing out. applying for ds8201a w nivolumab. hope they take me.
12/27/19 - begin ds8401a w nivolumab. after 2nd cycle nodes melt away. after 3rd cycle chest scan shows Improvement, brain MRI shows improvement, resolved areas & nothing new. switch to plain ENHERTU. after 4th cycle, PETscan shows mostly resolved or improved results. Markers near normal. I'm stunned but grateful.
10/26/20 - June 2021 Tucatinib/xeloda/herceptin - stable ish.
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Old 02-28-2008, 09:29 PM   #13
Jeanette
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Udders

Have to respond to this one Bill. I may be from Scotland, but I speak perfectly good Queens English. No barrier there. A cow has 1 udder and four teats or nipples. a cows udder can hold 10.6 gallons of milk. You can do a search on this if you want. I guess we can all agree to disagree on this one, Blessings , Jeanette
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Old 02-28-2008, 09:37 PM   #14
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Thanks Jeanette,
Bill's explanation was utterly unbelievable.
Thanks for the clarification ... I knew there
was something wrong with his story.
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Dx Aug/05 at age 51
2cm. Stage 2A, Grade 3
ER+/PR-
Her2 +++

Sept 7/05 Mastectomy
4 FAC, 4 Taxol, no radiation
1 year of Herceptin
Tamoxifen for approx. 4 months,
Arimidex for 5 years
Prophylactic mastectomy June 22/09



" I yam what I yam." - Popeye

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Old 02-28-2008, 09:52 PM   #15
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Cool uh oh

Have I done it again? Jeanette, I meant no offense. I know we Scots speak the perfect Queen's English. I was just trying to explain the colloquialism (sp?) of the colonial, known to us as, "Believe51". I was just trying to explain the origins of the term "cow utters", as discovered during my extensive researches into the history of milk-ranchers and their habits. I meant no harm. Bill
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Old 02-28-2008, 11:18 PM   #16
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Driving us udderly mad

Ok, picture this....my husband and I are in the same room....He keeps asking me why I am laughing. I am laughing so hard that I can not answer him. Finally he starts reading over my Irish shoulder and he laughs even louder. He wants to know if we should change the name from mad cow disease to the Udder Disease. Truth is, I thought I knew something about cow udders. My grandparents had a dairy and my father was one of the youngens that got rousted out of bed. Not sure when I first learned about bag balm, but it was a staple in our house. My mom put bag balm on any problem we had. Hey, Bill send us some of those potatoes maybe we can fuel our cars with them. Don't forget to send the cupcakes with the potatoes. Someone please tell Touseld about our Udder/Utter problem. Are two utters better than one?

Catherine
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Stage IIB, ER- PR- HER2+++ multi focal tumors, largest 2.3cm
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Old 02-29-2008, 08:23 AM   #17
Marlys
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How about Windex?

In the movie "My Big Fat Greek Wedding" her father used windex to cure everything. I will try that. too. Incidentally Bill, in addition to 31 years as an O.R. Nurse, I spent 10 years in psychiatric nursing and, by God, I think you just might qualify for membership.
Love & hugs,
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Old 02-29-2008, 09:00 AM   #18
Jeanette
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Talking udders

Bill, Bill, Bill. You silly man. You could never insult this old lady. I enjoy reading all your posts and get a chuckle out of them. But I am right about the dreaded udders. LOL Keep on posting and I will keep on correcting you if I see fit. Hehehe. Keeps the old mind alert you know. Love ya, jeanette
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Old 02-29-2008, 06:47 PM   #19
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OK, I'm throwing my 2 cents in! Believe it or not, there's another hand cream out there that's called "Udderly Smooth"....not as good as the old Bag Balm though, we too used it for everything in our house, ala the father in Greek Wedding!
Anyway Bill, you'll have to contact the company and tell them they got it wrong, it's supposed to be "Utterly Smooth"!

<3 Lolly
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Sept.'99 - Dx.Stage IIIB, IDC ER/PR-, HER2+++ by IHC, confirmed '04 by FISH. Left MRM, AC x's 4, Taxol x's 4, 33 Rads, finishing Tx May 2000. Jan.'01 - local/regional recurrence, Stage IV. Herceptin/Navelbine weekly till NED August 2001, then maintenance Herceptin. Right Mast. April 2002. Local/Regional recurrence April '04, Herceptin plus/minus chemo until May '07. Gemzar added from Feb.'07-April '07; Tykerb/Abraxane until August '07, back on Herceptin plus Taxotere and Xeloda Sept. '07. Stopped T/X Nov. '07, stopped Herceptin Dec. '07, started Avastin/Taxol/Carboplatin Dec. '07. Progression in chest skin, stopped TAC March '03, started radiation.

Herceptin has served as the "Backbone" of my treatment strategy for over 6 years, giving me great quality of life. In 2005, I was privileged to participate in the University of Washington/Seattle HER2 Vaccine Trial.
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Old 03-03-2008, 04:08 PM   #20
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Rather more mundane and my usual udderly boring bleat.

I have seen several references of omega 3s in the diet being good for cracked skin.

You could try it topically, I have seen suggestions it is absorbed. Any questions - just say wear wellington (gum) boots and say you have been fishing it is easier than explaining, unless you live in the middle of a city or plains in which case you will have to think of another excuse.


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