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Old 06-18-2014, 03:29 AM   #1
jkdowl
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Join Date: Jan 2011
Posts: 17
How long is it safe to stay on Zometa with bone mets

In Feb 2015, I will be on Zometa for 4 years. I have seen Friends develop femoral stress fx after being on Zometa for a long time (7 years). I have spaced the dosing out to every 12 weeks now, but wanted to know when I should stop.
My oncologist told me that I could stop now if I want. I have been stable on herceptin and zometa since 2011. I am afraid to change but I know that I eventually should stop. Any advice or past experience would be greatly appreciated!
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40 yo. mom to 7 yo old twins girls and 5 year old son

Dx- 12/6/10- stage IV to bone
Taxol/Herceptin/Zometa
CT scans and bone scan- STABLE 4/19/11, 6/12/11, 10/4/11
Stopped taxol 9/29/11
Continue herceptin,zometa
John Hopkins vaccine trial 4/12-11-12
CT scans and bone scan- NED 4/12, 7/12, 10/12, 2/13,6/13
Brain MRI-clear 6/13
Left breast progression 8/14, Ct scan and bone scan-clear
brain MRI- clear
Mastectomy left breast 9/14

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Old 06-18-2014, 05:31 AM   #2
sassy
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Join Date: Sep 2005
Location: Mountains of Virginia
Posts: 2,267
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Re: How long is it safe to stay on Zometa with bone mets

Hello JK,

I developed atypical femoral stress fractures after being on Zometa for seven years. Interestingly, my infusions were only twice annually.

The information I have found indicates that the fractures occur after extended use of bisphosphonates, typically exceeding five years.

Please feel free to PM me and I will be happy to share the information that I have found.

Best wishes,
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Rhonda (Sassy)
dx age 45
DX 2/15/05 Stage IIb (at surgery)restaged IIIa
Left mast .9cm tumor 5 of 14 nodes
Triple Positive
4 DD A/C
12 Taxol/Herceptin
33Rads
Strange infect mast site one year aft surg, hosp 1 wk
Herceptin for total of 18 months
Lupron Monthly 4 yrs
Neurontin for aches, pains and hot flashes(It works!)
Ovaries removed 11/09 stop Lupron and Neurontin
Arimidex 6 yrs (tried Femara, no SE improvement)
Tried Exemestane-hips got so bad could hardly walk
Back to Arimidex for year seven
Zometa 2X Annual for 7years, Lasix
Stop Arimidex 5/13
Stop Zometa 7/13-Bi-lateral Stress Fractures in Femurs from Zometa
5/14 Start Tamoxifen
3/15 Stem cell transplant to stimulate femur bone growth/healing
5/15 Complete fracture of right femur/Titanium rods both femurs
9/16 Start Evista stopTamoxifen
3/17 Stop Evista--unwelcome side effects!
NED and no meds.......
14YEARS NED!
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