Anyone suddenly have major diarrhea on tykerb?

[DeenaH]

After months with no problems? I started taking tykerb with herceptin in early January. I had the occasional loose stool, but sometimes would even get constipated. I was tolerating it really well for 5 months. Then I had a lung wedge resection on a Friday, and major diarrhea set in on Monday night. It has been constant diarrhea. Everything goes right through me. I have been tested for Cdiff twice (neg), had a colonoscopy with biopsies that were normal. Tried taking vancacin just in case the Cdiff test was false neg. No dice, it did nothing. I have tried immodium and limotil with no success. I was trying to get to my next pet/CT before making any treatment changes, and the scan is tuesday. I started navelbine 1 1/2 weeks after the diarrhea started, so it isn't that. After so long, I have landed in the hospital with dehydration, very low potassium and magnesium, 1.4 white cells (getting neupogen shots for that), and 8.2 red cells (getting 2 units of blood for that). They will also be trying to figure out the cause of the diarrhea. Anyone else had side effects from tykerb set it months after starting the drug?

Thanks for any info. I am really scared about dropping tykerb. Especially if it isn't the culprit.