Progression on Tykerb+Xeloda in 6 months

[supermehra]

Bad news for my Mom... Wanted to share here our experience:

History: her2 3+, ER-, PR- diagnosed in 2001... has had taxol, herceptin, gamma knife, RT twice 40, brain surgery.

Prior to treatment, she had 3 small lesions on liver, small lesion on sternum, recovering from surgery for solitary brain met (which was unremarkable in PET after surgery)

Treatment given :

6 months of Tykerb daily - 1250mg
6 months of Xeloda (2 week on/1 week off) - 2500mg (reduced from 3000mg due to side effects)


Post treatment :

Disease is now more widespread with growth of lesions in liver, large mass on Sternum, spread to collar bone and some axillary/lymph nodes. Also, there is recurrence in the bed of the originally removed brain tumor.

It's clear that Tykerb and Xeloda failed completely.


We are now reverting to herceptin+navelbine for the moment. Her best response was from Herceptin back in 2004 but was taken off by 2005 - so reason to believe it will still work for her.


Any thoughts, suggestions much appreciated.