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Old 05-29-2014, 01:34 PM   #1
'lizbeth
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Post Vaccine Boosters Reduce Recurrence of Breast Cancer

Vaccine Boosters Reduce Recurrence of Breast Cancer: Presented at SSO


March 18th, 2014


By Nancy A. Melville
PHOENIX, Arizona -- March 18, 2014 -- Adding boosters to the anti-human epidermal growth factor receptor 2 (HER2) peptide vaccine appears to decrease breast-cancer recurrence, researchers reported at the 67th Annual Cancer Symposium of the Society of Surgical Oncology (SSO).
The recurrence rate was reduced by 62.7% with booster inoculations.
The HER2 vaccine consists of GP2 -- a human leukocyte antigen (HLA) A2-locus-positive restricted immunogenic peptide from the HER2 protein that stimulates CD8-positive T cells to recognise and kill HER2-expressing tumour cells, explained lead author Erica J. Schneble, MD, San Antonio Military Medical Center, San Antonio, Texas, speaking here on March 14.
Data from the GP2-vaccine trial study “suggest that boosting CD8-eliciting, peptide vaccines will optimise their clinical benefit,” Dr. Schneble stated. The boosters have not added toxicity, she noted.
Dr. Schneble and colleagues evaluated 170 patients with HLA-A2+, high-risk breast cancer who were clinically disease-free. The patients had completed the primary vaccine series in the original study more than 6 months prior to the start of the booster study, and were offered a series of 4 booster vaccinations every 6 months (500 mcg GP2 peptide plus granulocyte macrophage colony-stimulating factor).
Among 170 patients who enrolled, which included 88 controls and 82 vaccinated women, 13 had not completed the primary vaccine series, 1 was declared ineligible, 4 had an early recurrence prior to the primary vaccine series completion, and 1 developed a secondary malignancy, leaving 63 patients for evaluation.
At a median of 39 months of follow-up, the patients’ recurrence rate was 5.0%, with 46 patients receiving boosters and 17 not receiving boosters.
The recurrence rate among those receiving boosters was 4.4% compared with 11.8% among those who did not receive boosters (P = .29).
The booster-inoculation safety profile was similar to that observed in the primary vaccination series; delayed urticarial reactions, defined as hypersensitivity reactions generally occurring 9 to 10 days post-inoculation, occurred in 6.5% of patients during the booster series, compared with 4.8% during the primary vaccination series (P = .51).
There were no differences between the booster and non-booster inoculation groups in terms of age, grade, nodal status, tumour size, oestrogen- or progesterone-receptor status, and HER2 expression.
“The GP2 vaccine is safe overall, and the current 5% recurrence rate is half that expected in this population,” the authors concluded.
Disclosure: Co-author George E. Peoples has partial inventor rights to GP2, and would be entitled to financial proceeds if licensed per federal policy.
[Presentation title: The Clinical Benefit and Safety of Boosting the HER2 Peptide Vac-
cine (GP2+GM-CSF) in the Adjuvant Setting to Prevent Breast Cancer Recurrence. Abstract #P6]
__________________
Diagnosed 2007
Stage IIb Invasive Ductal Carcinoma, Pagets, 3 of 15 positive nodes

Traditional Treatment: Mastectomy and Axillary Node Dissection followed by Taxotere, 6 treatments and 1 year of Herceptin, no radiation
Former Chemo Ninja "Takizi Zukuchiri"

Additional treatments:
GP2 vaccine, San Antonio Med Ctr
Prescriptive Exercise for Cancer Patients
ENERGY Study, UCSD La Jolla

Reconstruction: TRAM flap, partial loss, Revision

The content of my posts are meant for informational purposes only. The medical information is intended for general information only and should not be used in any way to diagnose, treat, cure, or prevent disease
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