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12-11-2010, 11:04 AM
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#1
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Senior Member
Join Date: Sep 2005
Location: Alaska
Posts: 2,018
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Obesity Linked to Worse Outcomes in Most Common Breast Ca Subtype
Obesity Linked to Worse Outcomes in Most Common Breast Ca Subtype
Elsevier Global Medical News. 2010 Dec 10, B Jancin
SAN ANTONIO (EGMN) – Baseline obesity in breast cancer patients possessing the estrogen receptor–positive, HER2-negative disease subtype was independently associated with a 23% higher risk of recurrence and nearly a 50% increase in all-cause mortality compared with rates in the nonobese in a first-of-its-kind study.
__________________
Dx 2002 age 51
bc for granny, aunt, cousin, sister, mother.
ER+/PR+/HER2+++, grade 3
IDC 1.9 cm, some DCIS, Stage 1, Grade 3
Lumpectomy, CAFx6 (no blood boosters), IMRT rads, 1 3/4 yr tamoxifen
Rads necrosis
BRCA 1 & 2 negative
Trials: Early detection OVCA; 2004 low-dose testosterone for bc survivors
Diet: Primarily vegetarian organic; metformin (no diabetes), vitamin D3
Exercise: 7 days a week, 1 hr/day
No trastuzumab, no taxane, no AI
NED
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12-12-2010, 02:33 PM
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#2
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Senior Member
Join Date: Jan 2008
Location: "Love never fails."
Posts: 5,808
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Re: Obesity Linked to Worse Outcomes in Most Common Breast Ca Subtype
Happened to come across today this article that offers some solutions:
http://www.nlm.nih.gov/medlineplus/e...cle/007297.htm
__________________
Jackie07
http://www.kevinmd.com/blog/2011/06/doctors-letter-patient-newly-diagnosed-cancer.html
http://www.asco.org/ASCOv2/MultiMedi...=114&trackID=2
NICU 4.4 LB
Erythema Nodosum 85
Life-long Central Neurocytoma 4x5x6.5 cm 23 hrs 62090 semi-coma 10 d PT OT ST 30 d
3 Infertility tmts 99 > 3 u. fibroids > Pills
CN 3 GKRS 52301
IDC 1.2 cm Her2 +++ ER 5% R. Lmptmy SLNB+1 71703 6 FEC 33 R Tamoxifen
Recc IIB 2.5 cm Bi-L Mast 61407 2/9 nds PET
6 TCH Cellulitis - Lymphedema - compression sleeve & glove
H w x 4 MUGA 51 D, J 49 M
Diastasis recti
Tamoxifen B. scan
Irrtbl bowel 1'09
Colonoscopy 313
BRCA1 V1247I
hptc hemangioma
Vertigo
GI - > yogurt
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Exemestane 25 mg tab 102912 ~ 101016 stopped due to r. hip/l.thigh pain after long walk
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1-2016 lesions in liver largest 9mm & 1.3 cm onco. says not cancer.
3-11 Appendectomy - visually O.K., a lot of puss. Final path result - not cancer.
Start Vitamin D3 and Calcium supplement (600mg x2)
10-10 Stopped Exemestane due to r. hip/l.thigh pain OKed by Onco 11-08-2016
7-23-2018 9 mm groundglass nodule within the right lower lobe with indolent behavior. Due to possible adenocarcinoma, Recommend annual surveilence.
7-10-2019 CT to check lung nodule.
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"I WANT TO BE AN OUTRAGEOUS OLD WOMAN WHO NEVER GETS CALLED AN OLD LADY. I WANT TO GET SHARP EDGED & EARTH COLORED, TILL I FADE AWAY FROM PURE JOY." Irene from Tampa
Advocacy is a passion .. not a pastime - Joe
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12-12-2010, 03:49 PM
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#3
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Senior Member
Join Date: Sep 2005
Location: Stockton, NJ
Posts: 4,179
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Re: Obesity Linked to Worse Outcomes in Most Common Breast Ca Subtype
Dear Angel
I read this with gusto. Although not obese, I fight hard to barely be in the normal range (as you and I have discussed may times).
My mother is obese (5'2" and 180 lbs) and she was diagnosed with bc just 3-4 months after me. At the end of this month, she will be 6 years out. She is getting more tests and has an appointment with our surgeon January 6 due to clustered calcifications in and around the scar tissue of her lumpectomy. Although her 5 years of Arimidex is "up" her onc kept her on anyway. I have always been fearful of a recurrence for her due to her unhealthy lifestyle which includes what she eats and drinks as well as no exercise whatsoever. Of course, right now we are not sure of what is really happening but I am not optimistic and will let you know the outcome but I feel my struggle has been worth the effort so far in that I have had no recurrence as of yet. We all have to fight the fat.
__________________
Kind regards
Becky
Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Prolia every 6 months for osteopenia
NED 18 years!
Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
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12-12-2010, 04:21 PM
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#4
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Senior Member
Join Date: Sep 2005
Location: Alaska
Posts: 2,018
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Re: Obesity Linked to Worse Outcomes in Most Common Breast Ca Subtype
My older sister has the same weight and exercise issues as your mom, Becky. My sister had early stage IDC 10 years ago with just rads + 2 weeks of tamoxifen, and it has never recurred. (No way to know whether at that time it was HER2 pos or not.)
But she now has IBC and falls neatly into this ER+, HER2 neg group. She lost 60 pounds during A/C and T this time, and got no benefit per her onc from A/C. It was during the Taxol that Femara was started and she improved. Thus, they are unable to discern whether the Taxol also was useless or not, and whether it is the continuing Femara alone that has made the difference, (plus the weight loss).
She is not on chemo now, just on Femara, and I worry that as she feels better and better she will start to gain some of the weight back, instead of continuing to lose. (Her BMI is still way above normal.)
The question also comes up as to whether these numbers would be even more conclusive about weight loss if there was a way to separate out whether balancing the types of fat eaten (omega's) is also meaningful.
If proportionately more HER2 positives are HR negative than positive and they lumped all the HER2's together in this study, then maybe weight management makes more of a difference for the HER2 pos/HR positives than the study would otherwise indicate?
A.A.
__________________
Dx 2002 age 51
bc for granny, aunt, cousin, sister, mother.
ER+/PR+/HER2+++, grade 3
IDC 1.9 cm, some DCIS, Stage 1, Grade 3
Lumpectomy, CAFx6 (no blood boosters), IMRT rads, 1 3/4 yr tamoxifen
Rads necrosis
BRCA 1 & 2 negative
Trials: Early detection OVCA; 2004 low-dose testosterone for bc survivors
Diet: Primarily vegetarian organic; metformin (no diabetes), vitamin D3
Exercise: 7 days a week, 1 hr/day
No trastuzumab, no taxane, no AI
NED
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12-14-2010, 08:52 AM
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#5
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Senior Member
Join Date: Sep 2009
Posts: 358
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Re: Obesity Linked to Worse Outcomes in Most Common Breast Ca Subtype
This reiterates what the WINS trial found. The women with Triple Negative disease had greater benefit from dietary fat reduction (? or resulting weight reduction). Overall, it is critical for women of all categories to monitor and target a healthy weight as the risk for a different breast cancer remains.
__________________
TanyaRD
Registered Dietitian
Board Certified Specialist in Oncology Nutrition
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