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Old 01-14-2007, 09:50 PM   #1
Tom
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Maybe you should read this study about G-CSF's

I don't know if the same problems might apply to red cell colony stimulating factors, but I will try to find out.

http://www.sciencedaily.com/releases...0112104159.htm
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Old 01-16-2007, 02:41 PM   #2
AlaskaAngel
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Question bone and blood cell production question

Tom,

I chose not to use G-CSF's when I had chemo. It prolonged my chemo by 1 1/2 months (every 4 weeks instead of 3, and dose dense was neither common nor proven at the time). So although being in treatment longer was not a pleasure I decided against using G-CSF's. So far I'm NED at 5 years out from treatment, Stage 1.

At the time there was controversy about use of some of the rbc hemopoietic stimulators.

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Old 01-16-2007, 03:51 PM   #3
Christine MH-UK
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Thanks for the info

I had major problems with neutropenia even with three weekly chemo, so I had alot of GCSF just to make it through (still I have made it to 2007, which was better than I think people thought I would probably do). I will definitely pester the oncologist about bone issues next time I see him.
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Old 01-16-2007, 10:05 PM   #4
Bev
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They didn't say if the mice were doing AC, etc so perhaps in combo with a cytoxin you wouldn't have the tumor growth.

I did not like the way Nuelasta made me feel. I wouldn't do it if WBC's are over 1.3.

Thanks for the info Tom. BB
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Old 01-23-2007, 03:17 AM   #5
fullofbeans
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Red face nothing is perfect..

I understand your concern, and thank you for the info especially relevant for bone mets to considere. I had dose dense chemo and became neutropenic, spent four days at hospital on drip when I had temperature, so G-CSF/neul for me was a welcome trade off for the rest of my treatment, so I would not be scared around people and my "lick everything that looks dirty" dog!! Luckily I did not get bone pain from it, and no apparent side effect except a huge WBC count, once up to 35 on neul. In a twisted way I told my self that these extra WBC may come useful at killing my herceptin marked cancer cell (antibodies), not sure it works that way but hey that was a reassuring thought..

Unfortunatly for what we have trade off and bashing at one thing to save another is the name of the game.
Love
Karina
__________________

35 y/o
June 06: BC stage I
Grade 3; ER/PR neg
Her-2+++; lumpectomies

Aug 06: Stage IV
liver mets: 6 tumours
July 06 to Jan 07: 2*FEC+6*Taxotere; 3*TACE; LITT
March 07- Sept 07: Vaccination trial (phase 2, peptide based) at the UW (Seattle).
Herceptin since 2006
NED til Oct 09
Recurrence Oct 2009: to internal mammary gland since October 2009 missed on Oct and March 2010 scan.. palpable nodes in May 2010 when I realised..
Nov 2011:7 mets to lungs progressing fast failed hercp/tykerb/xeloda combo..

superior vena cava blocked: stent but face remains puffy

April 2012: Teresa Trial, randomised to TDM1
Nov 2012 progressing on TDM1
Dec 2012 blockage of my airways by tumours, obliteration of these blocking tumours breathing better but hoping for more- at mo too many tumours to count in the lungs and nodes.

Dec 2012 Starting new trial S-222611 phase 1b dual egfr her2+ inhibitor.



'Under no circumstances should you lose hope..' Dalai Lama
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