I am still responding really well to the clinical trial of Herceptin and Avastin with further shrinkage of the skin mets. (Only one month!) It's really quite dramatic in my case with skin tumors melting away. The largest one which is completely gone was almost an inch. The worrisome thing is that I have hole (smaller than the tumor itself) there instead. It's draining quite a bit too. It's been a smelly, messy affair. My doctor told me not to worry, better not to have a tumor and she says the hole will close up. Wishing you all well, Carol
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