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Old 07-20-2007, 10:21 AM   #1
katsc49
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Smile dark finger nails and toenails???

Hi,
I have stage 4 mestatic breast cancer and been on herceptin and taxotere since January, 2007. Every time my onco sees me he always checks my hands and finger nails, but trecently my nails are all dark and blue and a toe nail, too. It this a side effect, too, of these drugs??
My onco says the lines in my fingernails are there to make them pretty but also said they are cancer lines.
Thank you,
katsc49
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Old 07-20-2007, 10:29 AM   #2
Believe51
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Oh Yah!!

Sweetie, my husbands nails were always the most fit looking, til chemo with these drugs. I suggest getting yourself into a good nail conditioner but ask the doctor for a suggestion first. Please use the search for nails, because this has been posted many times before and is many times a problem for this recipe of drugs.

Main thing is not to get nail fungus. Try the search, I am posting to keep this post up top until you can talk to the rest of the family about this.

Waiting For A Miracle>>Believe51
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9/7/06Husband 50yrs=StageIV IBC/HER2+,BoneMets10/06TaxotereX10,'H'1X wk,Zometa,Tamoxifen4/12/07Last Tax5/18/07Pet=Rapid Cell Activity,No Organ Mets,Lytic Lesions,Degeneration,Some Bone Repair5/07ChemoFail6/01/07Pleural Thoracentisis=Effusions,NoMalignantCells6/19/07+7/2/07DFCI
6/25/07BrainMRI=BrainMets,Many<9mm7/10/07WBR/PelvisRad37.5Gx15&Nutritionist8/19/07T/X9/20/07BrainMRI=2<2mm10/6/07Pet=BoneProgression
10/24/07ChemoFail11/9/07A/Cx10,EndTam12/7/07Faslodex12/10/07Muga7512/13/07BlasticLesions1/7/08BrainMRI=Clear4/1/08Pet=BoneImprovement,
NoProgression,Stable4/7/08BrainPerfect5/16/08Last A/C8/26/08BrainMets=10(<9mm)9/10/08Gamma10/30/08Met=5mm12/19/08Gamma5mets5
12/22/08SpinalMets1/14/09SpinalRads2/17/09BrainMRI=NoNewMets4/20/09BoneScan5/14/09Ixempra6/1/09BrainMRI=NumerousMets6/24/09DFCIw/DrBurstein6/26/09Continue
Ixempra/Faslodex/Zometa~TM now lower7/17/09Stop Ixempra By Choice9/21/09HOSPICE10/16/09Earned His Deserved Wings And Halo=37 Month Fight w/Stage 4 IBC, Her2+++,My Hero!!
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Old 07-20-2007, 10:50 AM   #3
Andrea Barnett Budin
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Wink Katsc49

Taxotere! One day I said to my husband I know this sounds strange but the tips of my fingers hurt! Yet another weird side effect I thought. Then my fingernails turned dark blue and then BLACK. Then they started lifting off the nail bed. There was this crusty oozy stuff between the nail and the bed. I went to a dermatologist to be certain it wasn't a fungus. NOT. I kept getting manicures weekly as I needed to cling to old routines as my head was bald so no real maintenance there. I did keep shampooing and conditioning, to keep my scalp fresh.

Any way, I switched to just a change of polish and used dark red nail polish to cover up the nails. They never fell off. I did 9 mnths of Taxotere. Once I said to my onc, I wish it was my toe nails, so people wouldn't have to look at it. No, if i were your toe nails, you'd have trouble walking. So careful what you wish for, as they say!

I've been on the Herceptin since '98 w/fatigue and flagging red bld cells (HGB) but absolutely no aches or pains or headaches. I do have a rashy looking declotee area but no itch. Just looks sunburnt. And a little on the inside of my upper arms. And I am always a bit foggy feeling. After all these years, I am used to living with the fog. I take supplements to help with the memory thing and they work! (Listed in 6/30 thread TO "SUPPLEMENT" OR WAIT, if you're interestede.)

Good luck. Wishing you NED forever... Sending loving, healthy energy your way... ANDI
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Andi BB
'95 post-meno dx Invasive LOBULAR w/9cm tumor! YIKES + 2/21 nodes. Clear mammo 10 mnths earlier. Mastec/tram flap reconst/PORT/8 mnths chemo (4Adria/8CMF). Borderline ER/PR. Tamoxifen 2 yrs. Felt BLESSED. I could walk and talk, feed and bathe myself! I KNEW I would survive...

'98 -- multiple mets to liver. HER2+ 80%. ER/PR- Raging, highly aggressive tumors spreading fast. New PORT. 9 mnths Taxotere Fought fire w/fire! Pronounced in cautious remission 5/99. Taxotere weekly for 6 wks, 2 wks off -- for 9 mnths. TALK ABOUT GRUELING! (I believe they've altered that protocol since those days -- sure hope so!!)
+ good old Vit H wkly for 1st 3 yrs, then triple dosage ev 3 wks for 7 yrs more... The "easy" chemo, right?! Not a walk in the park, but not a freight train coming at 'ya either...

Added Herceptin Nov '98 (6 wks after FDA fast-tracked it for met bc). Stayed w/Vit H till July '08! Now I AM FREE! Humbly and eternally grateful for this life-saving drug! NED since '99 and planning on keeping it that way. To hell w/poor prognosis and nasty stats! STOPPED VIT H JULY '08...! REMAIN STABLE... Eternally grateful...Yes is a world & in this world of yes live (skillfully curled) all worlds ... (e e cummings) EVERY DAY I BEAT MY PREVIOUS RECORD FOR # OF CONSECUTIVE DAYS I'VE STAYED ALIVE. Smile KNOWING you too can be a miracle. Up to me and God now...
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Old 07-20-2007, 10:51 AM   #4
hutchibk
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With Taxotere it is common for nails to get ugly. My chemo nurses told me to use Hard As Nails on my finger and toe nails all the time while on Taxotere and Tea Tree Oil on the cuticles... it prevented mine from any problems. No splitting or discoloration. I don't know if it's too late to start, but it wouldn't hurt to try.
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Brenda

NOV 2012 - 9 yr anniversary
JULY 2012 - 7 yr anniversary stage IV (of 50...)

Nov'03~ dX stage 2B
Dec'03~
Rt side mastectomy, Her2+, ER/PR+, 10 nodes out, one node positive
Jan'04~
Taxotere/Adria/Cytoxan x 6, NED, no Rads, Tamox. 1 year, Arimadex 3 mo., NED 14 mo.
Sept'05~
micro mets lungs/chest nodes/underarm node, Switched to Aromasin, T/C/H x 7, NED 6 months - Herceptin only
Aug'06~
micro mets chest nodes, & bone spot @ C3 neck, Added Taxol to Herceptin
Feb'07~ Genetic testing, BRCA 1&2 neg

Apr'07~
MRI - two 9mm brain mets & 5 punctates, new left chest met, & small increase of bone spot C3 neck, Stopped Aromasin
May'07~
Started Tykerb/Xeloda, no WBR for now
June'07~
MRI - stable brain mets, no new mets, 9mm spots less enhanced, CA15.3 down 45.5 to 9.3 in 10 wks, Ty/Xel working magic!
Aug'07~
MRI - brain mets shrunk half, NO NEW BRAIN METS!!, TMs stable @ 9.2
Oct'07~
PET/CT & MRI show NED
Apr'08~
scans still show NED in the head, small bone spot on right iliac crest (rear pelvic bone)
Sept'08~
MRI shows activity in brain mets, completed 5 fractions/5 consecutive days of IMRT to zap the pesky buggers
Oct'08~
dropped Xeloda, switched to tri-weekly Herceptin in combo with Tykerb, extend to tri-monthly Zometa infusion
Dec'08~
Brain MRI- 4 spots reduced to punctate size, large spot shrunk by 3mm, CT of torso clear/pelvis spot stable
June'09~
new 3-4mm left cerrebellar spot zapped with IMRT targeted rads
Sept'09~
new 6mm & 1 cm spots in pituitary/optic chiasm area. Rx= 25 days of 3D conformal fractionated targeted IMRT to the tumors.
Oct'09~
25 days of low dose 3D conformal fractionated targeted IMRT to the bone mets spot on rt. iliac crest that have been watching for 2 years. Added daily Aromasin back into treatment regimen.
Apr'10~ Brain MRI clear! But, see new small spot on adrenal gland. Change from Aromasin back to Tamoxifen.
June'10~ Tumor markers (CA15.3) dropped from 37 to 23 after one month on Tamoxifen. Continue to monitor adrenal gland spot. Remain on Tykerb/Herceptin/Tamoxifen.
Nov'10~ Radiate positive mediastinal node that was pressing on recurrent laryngeal nerve, causing paralyzed larynx and a funny voice.
Jan'11~ MRI shows possible activity or perhaps just scar tissue/necrotic increase on 3 previously treated brain spots and a pituitary spot. 5 days of IMRT on 4 spots.
Feb'11~ Enrolled in T-DM1 EAP in Denver, first treatment March 25, 2011.
Mar'11~ Finally started T-DM1 EAP in Denver at Rocky Mountain Cancer Center/Rose on Mar. 25... hallelujah.

"I would rather be anecdotally alive than statistically dead."
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Old 07-20-2007, 10:57 AM   #5
Andrea Barnett Budin
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Wink God Bless The Chemo Nurses

They are Angels sent to guide us. I got more useful information from them than all my oncs put together.

I started using NAILTIQUE (from beauty supply store) and Tea Tree Oil. Still do, all these years later. Thin, little girl nails manicurists have told me. They are forever peeling. I keep them short and neat, w/nude shades so you can't really notice the chipping. They're so weak I can't get a hold of the clasp on bracelets or necklaces. Can't wear them unless my husband is home. But I'M STILL HERE!

Love y'all.. ANDI
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Andi BB
'95 post-meno dx Invasive LOBULAR w/9cm tumor! YIKES + 2/21 nodes. Clear mammo 10 mnths earlier. Mastec/tram flap reconst/PORT/8 mnths chemo (4Adria/8CMF). Borderline ER/PR. Tamoxifen 2 yrs. Felt BLESSED. I could walk and talk, feed and bathe myself! I KNEW I would survive...

'98 -- multiple mets to liver. HER2+ 80%. ER/PR- Raging, highly aggressive tumors spreading fast. New PORT. 9 mnths Taxotere Fought fire w/fire! Pronounced in cautious remission 5/99. Taxotere weekly for 6 wks, 2 wks off -- for 9 mnths. TALK ABOUT GRUELING! (I believe they've altered that protocol since those days -- sure hope so!!)
+ good old Vit H wkly for 1st 3 yrs, then triple dosage ev 3 wks for 7 yrs more... The "easy" chemo, right?! Not a walk in the park, but not a freight train coming at 'ya either...

Added Herceptin Nov '98 (6 wks after FDA fast-tracked it for met bc). Stayed w/Vit H till July '08! Now I AM FREE! Humbly and eternally grateful for this life-saving drug! NED since '99 and planning on keeping it that way. To hell w/poor prognosis and nasty stats! STOPPED VIT H JULY '08...! REMAIN STABLE... Eternally grateful...Yes is a world & in this world of yes live (skillfully curled) all worlds ... (e e cummings) EVERY DAY I BEAT MY PREVIOUS RECORD FOR # OF CONSECUTIVE DAYS I'VE STAYED ALIVE. Smile KNOWING you too can be a miracle. Up to me and God now...
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Old 07-20-2007, 12:57 PM   #6
Chelee
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katsc, Unfortunetly the problems with your nails is mainly from the taxotere. The herceptin will make them weak and thin...split easy and break. But the Taxotere will make them black and blue and after a while they usually lift up and fall off. I did *TCH* and it was around the 4th or 5th cycle of TCH that my finger nails and both big toe nails got discolored. So yes...this is a side affect from the drugs. Sometimes your finger tips will get a bit numb too...kind of annoying but eventually it does get better. Mine are pretty much back to normal now. Hang in there.

Chelee
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DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes.
Rt. MRM on 1-3-06 -- No Rads due to compromised lungs.
Chemo started 2-7-06 -- TCH - - Finished 6-12-06
Finished yr of wkly herceptin 3-19-07
3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07
9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV.
9-28-09 Loading dose of Herceptin & started Zometa
9-29-09 Power Port Placement
10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head.
11-19-09 RT. Femur surgery - Rod placed
12-7-09 Navelbine added to Herceptin/Zometa.
3-23-10 Ten days of rads to RT femur. Completed.
4-05-10 Quit Navelbine--Herceptin/Zometa alone.
5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy.
Results to FISH was unsuccessful--this happens less then 2% of the time.
7-7-10 Recurrence to RT axilla again. Back to UCLA for options.
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Old 07-20-2007, 03:38 PM   #7
katsc49
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Hi,
Thanks so much from all the angels in this group!
It is getting difficult to walk but I see the onco on Monday.hugs,
kathy
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Old 07-20-2007, 09:38 PM   #8
weezie1053
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Katsc49,

I too had lovely black and reddish colored nails. My gal pals called me "Gothic Barbie." You need to notify your Oncologist of the first sign of infection. I started to notice brown crust behind the nail on my right hand, and I tried to clean it out with a manicure stick. I then smelt the infection. I have a sister who is a nurse, and she insisted I call my Oncologist, and it was a Saturday. They sent me to the local ER where I live in Podunk, VA and the onc on call even told me what antibiotic the local ER should prescribe. (I wish I could remember it.) The one finger had to be drained. I lost half of that nail. The next day, my other nails started to worsen, and my sister nagged me until I got in the car and drove to my Onc 2 hours away. If your finger tips hurt or you see anything oozing, call your Onc. You need to be on antibiotics. Also, my nails later lifted a little and turned white, but I was able to hide them under beige nail polish. I did, however, loose two toenails. All is coming back since I am off the chemo.

Good luck,

Louise (aka Gothic Barbie)
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  • Diagnosis 06/06 - Stage II-A BC; BC was 2.5 cm, grade 2; ER/PR negative & HER-2/neu positive;
  • Mastectomy w/ reconstruction (implant) in 09/06;lymph nodes - negative;
  • AC/Cytoxin combo - 4 treatments (dose dense);
  • Taxol/Herceptin combo- 12 weekly treatments;
  • Completed chemo - 2/07; completed restruction 02/07; reduction of left breast.
  • BRCA 1 and 2 negative - 6/15/07;DX high risk for distant recurrence
  • MRI, 08/02/07 - NED
  • 1 year Anniversary - 09/07; completed Herceptin 11/07.
  • Mammo 02/14/08 - NED; MRI - 08/2008 - NED
  • 2 year Anniversary - 09/08
  • Mammo 02/09 - NED; MRI - 08/09 - NED
  • 3rd year Anniversary - 09/09
  • 5th Annivery - 09/2011 - NED
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Old 07-23-2007, 11:01 AM   #9
katsc49
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nails

Hi everyone,
This is an update for the nails. I saw my onco today and he took one look at my nails and the big toe that is red, swelled and hurting, and said it was taxotere and he is taking me off of it for a month. does this mean there was toxcicity to it? I won't be put back on it. He didn't order pain med. , just said to use ice.
Thanks again,
have a good night,
kathy
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Old 07-23-2007, 08:06 PM   #10
weezie1053
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Kathy, I was fortunate in that, although my hands hurt before I completed the chemo (Taxol), the infection was not visible until the week I completed my chemo. My hands were throbbing the last few weeks of my chemo, and my Onc kept telling me that if I could hold on, he was going for a "cure." Another Oncologist in the same practice commented they could have cut back on the treatment. At one time I was on Neurontin for the pain. I still have some numbness and swelling in my feet, but my hands are all better. I think your Onc is probably to save you the complications I experienced. Hang in there! Things will eventually subside.

Louise
__________________
  • Diagnosis 06/06 - Stage II-A BC; BC was 2.5 cm, grade 2; ER/PR negative & HER-2/neu positive;
  • Mastectomy w/ reconstruction (implant) in 09/06;lymph nodes - negative;
  • AC/Cytoxin combo - 4 treatments (dose dense);
  • Taxol/Herceptin combo- 12 weekly treatments;
  • Completed chemo - 2/07; completed restruction 02/07; reduction of left breast.
  • BRCA 1 and 2 negative - 6/15/07;DX high risk for distant recurrence
  • MRI, 08/02/07 - NED
  • 1 year Anniversary - 09/07; completed Herceptin 11/07.
  • Mammo 02/14/08 - NED; MRI - 08/2008 - NED
  • 2 year Anniversary - 09/08
  • Mammo 02/09 - NED; MRI - 08/09 - NED
  • 3rd year Anniversary - 09/09
  • 5th Annivery - 09/2011 - NED
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Old 07-23-2007, 08:17 PM   #11
tousled1
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With the Taxatore I lost the nail on one of my big toes. It never turned black - just sort of got all gray looking and began lifting off the nail bed. Eventually it fell off and I had a new nail under it. Other than than no problems with the nails.
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Stage IIIC Diagnosed Oct 25, 2005 (age 58)
ER/PR-, HER2+++, grade 3, Ploidy/DNA index: Aneuploid/1.61, S-phase: 24.2%
Neoadjunct chemo: 4 A/C; 4 Taxatore
Bilateral mastectomy June 8, 2006
14 of 26 nodes positive
Herceptin June 22, 2006 - April 20, 2007
Radiation (X35) July 24-September 11, 2006
BRCA1/BRCA2 negative
Stage IV lung mets July 13, 2007 - TCH
Single brain met - August 6, 2007 -CyberKnife
Oct 2007 - clear brain MRI and lung mets shrinking.
March 2008 lung met progression, brain still clear - begin Tykerb/Xeloda/Ixempra
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Old 07-24-2007, 01:41 PM   #12
michka
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Post

I lost 5 toe nails and 3 others turned black with Taxol.
Michka
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08.2006 3 cm IDC Stage 2-3, HER2 3+ ER+90% PR 20%
FEC, Taxol+ Herceptin, Mastectomy, Radiation, Herceptin 1 year followed by Tykerb 1 year,Aromasin /Faslodex

12.2010 Mets to liver,Herceptin+Tykerb
03.2011 Liver resection ER+70% PR-
04.2011 Herceptin+Navelbine+750mg Tykerb
06.2011 Liver ned, Met to sternum. Added Zometa 09.2011 Cyberknife for sternum
11.2011 Pet clear. Stop Navelbine, continuing on Hercpetin+Tykerb+Aromasin
02.2012 Mets to lungs, nodes, liver
04.2012 TDM1, Ned in 07.2012
04.2015 Stop TDM1/Kadcyla, still Ned, liver problems
04.2016 Liver mets. Back on Kadcyla
08.2016 Kadcyla stopped working. mets to liver lungs bones
09.2016 Biopsy to liver. no more HER2, still ER+
09.2016 CMF Afinitor/Aromasin/ Xgeva.Met to eye muscle Cyberknife
01.2017 Gemzar/Carboplatin/ Ibrance/Faslodex then Taxotere
02.2017 30 micro mets to brain breathing getting worse and worse
04.2017 Liquid biopsy/CTC indicates HER2 again. Start Herceptin with Halaven
06.2017 all tumors shrunk 60% . more micro mets to brain (1mm mets) no symptoms
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Old 07-24-2007, 05:57 PM   #13
Andrea Barnett Budin
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Wink Micka

Were you able to walk w/o toe nails?

I once lost a big toe nail from a bang I couldn't even recall. And I was shocked that it didn't hurt. Plus it grew back so fast! I painted my bare toe w/red polish to match the other 9 because it looked weird having only 9 toe nails. It was summer. Sandal time. (In Fla. it's always sandal time.)

When I had the ebony black finger nails and lifting from the nail bed w/oozy crusty yuck in the middle, easily visible, I had pain in my fingertips. Did you have pain too? Mine was from Taxotere. Unusual they told me, but listed as a possible side effect... ANDI
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Andi BB
'95 post-meno dx Invasive LOBULAR w/9cm tumor! YIKES + 2/21 nodes. Clear mammo 10 mnths earlier. Mastec/tram flap reconst/PORT/8 mnths chemo (4Adria/8CMF). Borderline ER/PR. Tamoxifen 2 yrs. Felt BLESSED. I could walk and talk, feed and bathe myself! I KNEW I would survive...

'98 -- multiple mets to liver. HER2+ 80%. ER/PR- Raging, highly aggressive tumors spreading fast. New PORT. 9 mnths Taxotere Fought fire w/fire! Pronounced in cautious remission 5/99. Taxotere weekly for 6 wks, 2 wks off -- for 9 mnths. TALK ABOUT GRUELING! (I believe they've altered that protocol since those days -- sure hope so!!)
+ good old Vit H wkly for 1st 3 yrs, then triple dosage ev 3 wks for 7 yrs more... The "easy" chemo, right?! Not a walk in the park, but not a freight train coming at 'ya either...

Added Herceptin Nov '98 (6 wks after FDA fast-tracked it for met bc). Stayed w/Vit H till July '08! Now I AM FREE! Humbly and eternally grateful for this life-saving drug! NED since '99 and planning on keeping it that way. To hell w/poor prognosis and nasty stats! STOPPED VIT H JULY '08...! REMAIN STABLE... Eternally grateful...Yes is a world & in this world of yes live (skillfully curled) all worlds ... (e e cummings) EVERY DAY I BEAT MY PREVIOUS RECORD FOR # OF CONSECUTIVE DAYS I'VE STAYED ALIVE. Smile KNOWING you too can be a miracle. Up to me and God now...
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