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Old 01-14-2007, 12:33 PM   #1
hannah
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Symadex
Has anybody had a course of symadex chemo and do you know if it crosses blood/brain barrier.
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Old 01-14-2007, 11:31 PM   #2
Chelee
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I personally haven't heard of this...but I thought I would bump this up.

Chelee
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DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes.
Rt. MRM on 1-3-06 -- No Rads due to compromised lungs.
Chemo started 2-7-06 -- TCH - - Finished 6-12-06
Finished yr of wkly herceptin 3-19-07
3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07
9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV.
9-28-09 Loading dose of Herceptin & started Zometa
9-29-09 Power Port Placement
10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head.
11-19-09 RT. Femur surgery - Rod placed
12-7-09 Navelbine added to Herceptin/Zometa.
3-23-10 Ten days of rads to RT femur. Completed.
4-05-10 Quit Navelbine--Herceptin/Zometa alone.
5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy.
Results to FISH was unsuccessful--this happens less then 2% of the time.
7-7-10 Recurrence to RT axilla again. Back to UCLA for options.
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Old 01-15-2007, 07:32 AM   #3
Kimberly Lewis
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I looked it up online as I also have not heard of it. I found that it is still in clinical trials stage 2. Not much to be found where I looked anyway. Sorry!
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 Diagnosed 7/05
Stage 3a er+(45%) pr+(68%) Her2+ (40%)
3.8 cm + .8cm multi focal - pleomorphic lobular tumors
high grade DCIS
7/20 nodes
BRCA 2 positive as of 5/07
surgeries: double mastectomy, hysterectomy (LAVH)
A/C,Herceptin for 1 year completed 11/06
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Old 01-15-2007, 03:32 PM   #4
hannah
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thanks for your help

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Old 01-15-2007, 04:02 PM   #5
MGordon
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Symadex - quick research topics...
Hannah -

Might not be much help but here is a little web reseacrh.

http://www.xanthus.com/products_symadex.htm- drug company's link

http://www.pharmaceutical-business-review.com/article_news.asp?guid=%7B0180FB36-8421-4D03-8366-1F20BC0A4F7B%7D - Pharm Business Review - states this drug is also used for auto-immune disease - especially with MS. ( HavahJ are you reading this!) Currently in Phase II trials for Colorectal and B/C - preclinical for auto-immune. (http://www.xanthus.com/pdf/xanthus_factsheet.pdf).



http://www.prnewswire.com/cgi-bin/stories.pl?ACCT=104&STORY=/www/story/02-13-2006/0004280425&EDATE more about MS but read this: "The early results from this study showed that the animals in the study, which were paralyzed due to neurological impairment, were able to recover and regain their mobility after treatment with Symadex," commented Dr. Karlik. "Symadex is now in Phase 2 trials in oncology and the positive results of this animal model study show the candidate's potential for treating MS and provide the support needed to advance Symadex towards human trials for MS," said Michael A. Boss, PhD. Chief Business Officer at Xanthus.

http://202.127.145.151/Dig_Lib/ReadingRoom/ASMS/2005/sessions/pdfs/A052679.pdf - States that is does in fact cross the blood/brain barrier.

"C-1311 (Symadex) readily sequesters in tumor cell nuclei

resulting in G2M cell cycle disruption, has shown significant

activity in colorectal cancer models, and crosses the blood

brain barrier, suggesting potential for treatment of brain

tumors [4]. The drug is currently in phase I clinical trials."

Hope this helps...
Love and Light
Mel
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