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Old 12-13-2006, 07:36 AM   #1
RhondaH
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Exclamation ***Glaxo starts test of Tykerb in early breast cancer***

I want to find out if having Herceptin prior would exclude some of us?

http://today.reuters.com/news/articl...c=66&type=qcna

Rhonda
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Rhonda

Dx 2/1/05, Stage 1, 0 nodes, Grade 3, ER/PR-, HER2+ (3.16 Fish)
2/7/05, Partial Mastectomy
5/18/05 Finished 6 rounds of dose dense TEC (Taxotere, Epirubicin and Cytoxan)
8/1/05 Finished 33 rads
8/18/05 Started Herceptin, every 3 weeks for a year (last one 8/10/06)

2/1/13...8 year Cancerversary and I am "perfect" (at least where cancer is concerned;)


" And in the end, it's not the years in your life that count. It's the life in your years."- Abraham Lincoln
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Old 12-13-2006, 08:01 AM   #2
Joe
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More on the trial:

http://www.clinicaltrials.gov/ct/sho...374322?order=1


We will discuss the elegibility with GSK while in San Antonio.

Regards
Joe
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Old 12-15-2006, 04:56 PM   #3
AlaskaAngel
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TEACH trial

Here is one more reference for this trial:

http://www.medicalnewstoday.com/medi...p?newsid=58964
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Old 12-17-2006, 02:20 AM   #4
lili7
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Teach

Thank you for the information. I am interested in this trial as I am the one that could not tolerate Herceptin ( Stopped at the 4th dosis) It seems that if you had Herceptin you are not allowed to participate.
Anybody knows if it is approved in Canada?
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Old 12-17-2006, 07:30 AM   #5
tousled1
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Lili7,

According to the article Dr. Kathleen Pritchard, Toronto, Canada is on the TEACH Steering Committee. That might be a good point to start research on whether it will be available in Canada
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Kate
Stage IIIC Diagnosed Oct 25, 2005 (age 58)
ER/PR-, HER2+++, grade 3, Ploidy/DNA index: Aneuploid/1.61, S-phase: 24.2%
Neoadjunct chemo: 4 A/C; 4 Taxatore
Bilateral mastectomy June 8, 2006
14 of 26 nodes positive
Herceptin June 22, 2006 - April 20, 2007
Radiation (X35) July 24-September 11, 2006
BRCA1/BRCA2 negative
Stage IV lung mets July 13, 2007 - TCH
Single brain met - August 6, 2007 -CyberKnife
Oct 2007 - clear brain MRI and lung mets shrinking.
March 2008 lung met progression, brain still clear - begin Tykerb/Xeloda/Ixempra
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Old 12-17-2006, 07:48 PM   #6
PatS
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Lili7 - If you go to this link and scroll down, you'll see centers in Canada who are going to participate.

http://www.clinicaltrials.gov/ct/sho...374322?order=1

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Old 12-21-2006, 02:22 PM   #7
Adriana Mangus
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Tykerb

I think we will be able to qualify for Tykerb regardless of use of herceptin. Actually -if I remember it correctly- the combinatin of two are more effective than either one alone.. My onc does not believe I am in need of it, at this point but it's not oposed if I needed it....Best regards.
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1994 - rt brst, .lump, underarm node dissection,chemo+rad 1.2 cms, Grade 3.
28 nodes neg
Er,Pr, Positive HER2 status unknown
2003- Recur to rt lung.July 16 ( B-Day!)
Her2+++ Er,Pr, Negative
2003 - Aug04--Navelbine + Herceptin
2004- 2007--
NED - Herceptin, only
2007 Feb-April Xeloda added to hereceptin
2007-May Back on Navelbine+Herceptin
2008-Feb-Mar 15 Ses Rad to Rt. Lung
2008- Oc 17 Add Tykerb to Herceptin
2009- June-- Discont Tykerb
2009 July 7--Current Taxol + Herceptin
2009 Dec--Discontinued treatment due to progression. Looking into cyberknife.
2010-Aug Accepted to TDM1, no SE, except liver count went up.
2010-2011 September got kicked out of the trial, due to a small spot found on lung.
2011- 2012 September thru early 2013 on Herceptin
2013- March Bone density shows small spot on 5th rib.
2013 - April 4th appt with onc. will post after discussing course of treatment.
2013-March-April Cyber knife to brain and radiation to rib. Chest --base line before chemo-CT-Scan stable for lung issue. CA2729 Normal.
2013 April Herceptin- TDMI
2013 Sept Herceptin + Perjeta . CA2729 within normal range. Brain and Pet scans October 31st. will post results.
2013 October Brain MRI- mixed response. Will see Onc/rad on Halloween.
2013 October/November Brain-MRI nothing new. Repeat MRI next year in May.

2013 December Continue Herceptin and Perjeta. Stable at the moment.
2014 February Brain MRI -clear!
2014 January Added Taxotere to Perjeta+Herceptin.
2014 March Stopped chemo-chest ct-scan next.

2014- March Scans shows tumor's larger, CA2729 higher. Discontinue Herceptin.
2014 April Perjeta+ Halaven
2014 April CA2729 went down 60 points after one cycle. Cough does not want to go away.
2014 June Continue on Perjeta + Halaven-- no more cough. Stable
2014 June Back on Herceptin + abraxane
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Old 12-21-2006, 07:56 PM   #8
lili7
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Smile TYkerb info ~ Thank you note

Thank you all for answering ....What a wonderful group! I am pursuing Tykerb as I am the one who had the horrible neuropathy reaction after my 4th dosis with Herceptin.

Hugs all, Happy Holidays!
LOVE
PEACE
LILI7
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Old 01-16-2007, 11:22 AM   #9
laylward
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Any answer on whether herceptin disqualifies you from Tykerb trial?

Rhonada, Joe;

Any answer, perhaps from talking to GSK at SABC, whether herceptin use disqualifies one from participating in the TEACH trial of Tykerb in a nonmetastic, adjuvant setting? I would love to get in this trial, but from the website, it seems like you have to be Her2neu but NOT have used herceptin? I've called the phone no. for the trial (1-877-379-3718) but just get answering machine. Will also put a call into Dr. Minetta Liu at Georgetown who is listed as one of the researchers of the DC location of the trial, but would be grateful if anyone else has some info?

I am elgible for the Windber, PA vaccine trial, but don't want to start it, if a Tykerb trial were available. In that regard, am going to make a second post to see if anyone has insights on the peptide vs the DNA-based vaccine.

thanks,
Lynn in DC
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Old 01-16-2007, 11:45 AM   #10
Becky
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In the TEACH trial, you cannot have used Herceptin and you must be Stage 1 - 3A.
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Kind regards

Becky

Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Prolia every 6 months for osteopenia

NED 18 years!

Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
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Old 01-20-2007, 05:59 AM   #11
Joannie
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I too have called the number several times. All you get is the answering machine. They called back twice on the same day, two different people left messages. Unfortunately, when you call back, you get the answering machine! I would love to know if I'm eligible.
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