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Old 07-21-2010, 02:46 PM   #1
mommaS
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How fast can skin mets occur

I am new to the boards but have had a roller coaster week of thinking I am heading for surgery to now possible mets to my bones and skins. The mets to my bones might be a false positive on the PET/CT due to recent GCSF shots to boost my immune system during the previous 24 weeks of chemo. Yesterday, however, we met with our surgeon to discuss the future possibility of a modified radical mastectomy, and I showed her these little bumps on my left breast that had appeared over the last two days. Needless to say they were suspicious and I left the office after two small skin biopsies where taken. Wonder if mets to skin has occurred for anyone else so quickly after six months of chemo?
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Momma Sharon

1/7/10 Diagnosed IBC while BF twins a pleomorphic infiltrating lobular carcinoma; 12x9 cm; ER+, PR+, HER-2/neu++; Ki-67 80%
1/25/10 MRI of brain/scan of bone neg-
1/27/10 PET Scan-hypermetabolism in left breast axillary; right mediastinal, left and right supraclavicular and internal mammary lymph nodes
1/29/10 Port Placement, started 24 weeks of chemotherapy with: Trastuzumab- Herceptin, Paclitaxel- Taxol, and Vinorebine- Navelbine
7/9/10 Finished 24th chemo treatment
7/15/10 PET/CT showed excellent response in nodes and breast; possible bone mets
7/16/10 Began Herceptin@ 3 wks and Zometa @6 wks plus Lupron and Femera
7/29/10 Diagnosed with HER+,ER-,PR- skin mets; started Doxil & Cytoxin; no response
11/5/10 PET/CT mets to bone, liver, lung, adrenal; started Xeloda
11/12/10 Brain MRI-Brain Mets, stopped Xeloda, started WBRT 11/16 and Tykerb on 11/19
12/6/10 completed 15 rounds WBRT
12/19/10 restarted Xeloda

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Old 07-21-2010, 09:40 PM   #2
ElaineM
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Wink Re: How fast can skin mets occur

You can go towww. ibcsupport.org and do a search for breast cancer skin mets. There is alot of information available and many posts from people who experienced skin mets.
Good luck. Take good care of yourself.

http://www.ibcsupport.org/search.php?q=skin+mets&s=s

http://www.ibcresearch.org/left-side/site-map/

http://ibcwatch.evidencewatch.com/
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Last edited by ElaineM; 07-22-2010 at 10:08 AM.. Reason: additions
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Old 07-22-2010, 10:21 AM   #3
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Wink Re: How fast can skin mets occur

The correct address of IBC support is www.ibcsupport.org.
The other links have information about skin mets too.
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Lucky 13 !! I hope so !!!!!!
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14 Year Survivor
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"You never know how strong you are until being strong is the only choice you have." author unknown
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Old 10-27-2010, 11:26 PM   #4
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Re: How fast can skin mets occur

I think Tricia might be referring to me.... About 3 months ago I posted that I had been diagnosed with early stage melanoma and there was a string going regarding the link between bc and melanoma. I was lucky in that I didn't need to do further treatment after they finally got clean margins. Mine was in a mole and very different than the skin mets described here. But great information - I had never heard of skin mets before so thanks for your post.
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Old 11-03-2010, 05:41 AM   #5
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Re: How fast can skin mets occur

Sharon, what kind of bump did you have? I also found a few red acne-like bump near my drain scar and also on the skin in the middle of bilateral mastectomy. Have you got them tested? Best wishes, Meg
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Aug. 5 2010 See family dr for bloody discharge from right breast (age 38)
Aug. 8 mammo and us, suspicious tumor (tumor has been there since 15 ys old, B9 in 2001 by fine needle biopsy)
Sep 13 lumpectomy and SNB (SNB is clear but margin in breast found DCIS)
Oct 8 abdomen US: clear (fibroid in uterus which was there bf)
Oct 12 whole body scan: clear
Oct 18 BMX: multifocal mucinous (margin 1cm, tumor size 3*2.8*2.5 cm) and multifocal DCIS (margin 0.7 mm, one is 1.7cm) in right breast, left breast found benign lumps
Oct 28 told tumor is triple positive
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Old 11-07-2010, 06:16 AM   #6
mommaS
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Re: How fast can skin mets occur

Sounds like possible skin mets. Mine looked like acne as well and I could definitely feel the nodule underneath the skin.

My skin biospy results came back HER+, ER-, PR-. which was different then my primary cancer pathology. Doctor started me on Doxil and Cytoxin but after three months, cancer markers were going up and my breast had not changed visably.

S
can results this week were not good and I have mets all over the place. Inflammatory breast cancer seems to spread like a wildfire even though I was on a chemo that should have worked in addition to Herceptin. I am now on Xeloda with Tykerb likely to follow soon.
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Momma Sharon

1/7/10 Diagnosed IBC while BF twins a pleomorphic infiltrating lobular carcinoma; 12x9 cm; ER+, PR+, HER-2/neu++; Ki-67 80%
1/25/10 MRI of brain/scan of bone neg-
1/27/10 PET Scan-hypermetabolism in left breast axillary; right mediastinal, left and right supraclavicular and internal mammary lymph nodes
1/29/10 Port Placement, started 24 weeks of chemotherapy with: Trastuzumab- Herceptin, Paclitaxel- Taxol, and Vinorebine- Navelbine
7/9/10 Finished 24th chemo treatment
7/15/10 PET/CT showed excellent response in nodes and breast; possible bone mets
7/16/10 Began Herceptin@ 3 wks and Zometa @6 wks plus Lupron and Femera
7/29/10 Diagnosed with HER+,ER-,PR- skin mets; started Doxil & Cytoxin; no response
11/5/10 PET/CT mets to bone, liver, lung, adrenal; started Xeloda
11/12/10 Brain MRI-Brain Mets, stopped Xeloda, started WBRT 11/16 and Tykerb on 11/19
12/6/10 completed 15 rounds WBRT
12/19/10 restarted Xeloda

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Old 11-07-2010, 11:15 AM   #7
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Wink Re: How fast can skin mets occur

Hi,
Have you seen these two threads about skin mets? There are alot links and some information about skin mets and suggestions on how to treat them between the two links below. In fact one of the on going clinical trials for skin mets is located at the Washington Tumor Group in your state. You or your doctor might want to give them a call. The information is in one of the links below.
The two conventional creams used for breast cancer skin mets are Aldara (Immiquimod) and 5 Fu cream (which is Xeloda in cream form).

http://her2support.org/vbulletin/showthread.php?t=45308

http://her2support.org/vbulletin/showthread.php?t=47383
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12 years and counting
http://her2support.org/vbulletin/showthread.php?t=48247
Lucky 13 !! I hope so !!!!!!
http://her2support.org/vbulletin/showthread.php?t=52807
14 Year Survivor
http://her2support.org/vbulletin/showthread.php?t=57053
"You never know how strong you are until being strong is the only choice you have." author unknown
Shared by a multiple myeloma survivor.
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Old 11-07-2010, 08:37 PM   #8
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Wink Re: How fast can skin mets occur

University of Washington Tumor Group

http://depts.washington.edu/tumorvac...ntific_131.php
It is a clinical trial using Abraxane and Immiquimod cream (Aldara)for skin mets.
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Peace,
ElaineM
12 years and counting
http://her2support.org/vbulletin/showthread.php?t=48247
Lucky 13 !! I hope so !!!!!!
http://her2support.org/vbulletin/showthread.php?t=52807
14 Year Survivor
http://her2support.org/vbulletin/showthread.php?t=57053
"You never know how strong you are until being strong is the only choice you have." author unknown
Shared by a multiple myeloma survivor.
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Old 11-09-2010, 09:40 AM   #9
Mary L
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Smile Re: How fast can skin mets occur

I fought skin mets for 5 years. Everytime I would take a break from Herceptin{because of Heart concerns} it would come back. Mine was apparent by the red inflammation that would start on my mastecetomy site and travel across my chest. As soon as I would go back on Herceptin, it would go away. Finally after 5 years of Herceptin I am off Herceptin and cancer free for 3 years. Wish you well. Mary L
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Old 11-11-2010, 07:21 AM   #10
Mary L
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Re: How fast can skin mets occur

Good Morning MommaS. Just a quick note to sy Hello and tell you I hope your surgery went well. I was thinking about you so I decided to drop you a note. I hope you are doing well. When you are able, send me an update on how you are doing. Best wishes. Mary L
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Mary L from PA Diag: Oct 2003 w/6mm mass, IDC grade III ductal carcinoma in-situ, IBC stage IIIB. tx A/C followed by Taxotere(only able to have 2 tx, allergic), mastectomy, 3 0ut of 7 positive nodes. 35 rads. Recurrence 9 months later, skin mets to mastectomy site. Tx Carboplatin/Herceptin. Stayed on Herceptin almost 5 years, had 3 more recurrences when I had to stop Herceptin due to my ejection fraction getting too low. Herceptin stopped and ned 3 years in Oct. 2010.
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Old 11-11-2010, 08:18 AM   #11
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Red face Re: How fast can skin mets occur

Hi MommaS, just wishing you well on your new drug combination. I am on tyverb/xeloda with herceptin for skin mets and lung mets. The lung mets are clearing fast and the herceptin stopped the skin mets from oozing. They are still visible but not spreading and I am hoping that if I stay on herceptin longterm like MaryL that they will finally go away. Very best wishes to you, I hope your next scan shows good results.
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Delaney, dx 2008 lumpectomy,mastectomy,a/c,paxitaxol, tyverb 1 yr.
dx 2010 mets lymph nodes, skin, lung. start taxotere/herceptin.
Stopped taxtere/herceptin, now on tyverb/xeloda.
Lung mets shrinking.
Back on Herceptin with T/X. Partial response.
Skin mets progressing. Radiation scheduled mid february 2011.
Spot found on hip - radiation to hip beginning mid February 2011.
Now trying Gemzar/Tyverb/Herceptin and Zometa.
CT scan Feb 2011 - lung clear!
Brain mets (specks) - radiation mid Feb.
Brain Scan June'11 - Clear
CT Scan June'11 - Good - skin met active - watch and wait.
Surgery to remove skin met. Surgery to back 2012, four titanium rods inserted. Skin mets reappear. On Navelbine, not working. 4 week washout, start Myocet for skin and lung mets August 2012. Brain scan clear despte intermittent blurry vision (something hiding? Am suspicious but hopeful. )On we go, glad to be here.
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Old 01-03-2011, 01:26 AM   #12
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Re: How fast can skin mets occur

Momma Sharon,

How is the vaccine trial going?
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http://www.kevinmd.com/blog/2011/06/doctors-letter-patient-newly-diagnosed-cancer.html
http://www.asco.org/ASCOv2/MultiMedi...=114&trackID=2

NICU 4.4 LB
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3 Infertility tmts 99 > 3 u. fibroids > Pills
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IDC 1.2 cm Her2 +++ ER 5% R. Lmptmy SLNB+1 71703 6 FEC 33 R Tamoxifen
Recc IIB 2.5 cm Bi-L Mast 61407 2/9 nds PET
6 TCH Cellulitis - Lymphedema - compression sleeve & glove
H w x 4 MUGA 51 D, J 49 M
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Tamoxifen B. scan
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GI - > yogurt
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Exemestane 25 mg tab 102912 ~ 101016 stopped due to r. hip/l.thigh pain after long walk
DEXA 1/13
1-2016 lesions in liver largest 9mm & 1.3 cm onco. says not cancer.
3-11 Appendectomy - visually O.K., a lot of puss. Final path result - not cancer.
Start Vitamin D3 and Calcium supplement (600mg x2)
10-10 Stopped Exemestane due to r. hip/l.thigh pain OKed by Onco 11-08-2016
7-23-2018 9 mm groundglass nodule within the right lower lobe with indolent behavior. Due to possible adenocarcinoma, Recommend annual surveilence.
7-10-2019 CT to check lung nodule.
1-10-2020 8mm stable nodule on R Lung, two 6mm new ones on L Lung, a possible lymph node involvement in inter fissule.
"I WANT TO BE AN OUTRAGEOUS OLD WOMAN WHO NEVER GETS CALLED AN OLD LADY. I WANT TO GET SHARP EDGED & EARTH COLORED, TILL I FADE AWAY FROM PURE JOY." Irene from Tampa

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Old 01-04-2011, 03:16 PM   #13
mommaS
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Re: How fast can skin mets occur

Jackie:

I am not in the vaccine trial but plan to discuss with my oncologist. I was diagnosed with brain mets in November and recently underwent 15 rounds of WBRT. I was able to restart my oral chemo (xeloda) and am currently on my week off. I am also on tykerb which I started in November. So far, my cancer markers are dropping. Brain MRI on Jan 21 to see where things are at...although I have been told it may take three months to be able to see how effective the WBRT was on my IBC mets to brain. Skin mets are still present but the skin seems to be intact so far and new chemo seems to be effective.

Hanging in there and hoping 2011 gives me a break.

Sharon
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Momma Sharon

1/7/10 Diagnosed IBC while BF twins a pleomorphic infiltrating lobular carcinoma; 12x9 cm; ER+, PR+, HER-2/neu++; Ki-67 80%
1/25/10 MRI of brain/scan of bone neg-
1/27/10 PET Scan-hypermetabolism in left breast axillary; right mediastinal, left and right supraclavicular and internal mammary lymph nodes
1/29/10 Port Placement, started 24 weeks of chemotherapy with: Trastuzumab- Herceptin, Paclitaxel- Taxol, and Vinorebine- Navelbine
7/9/10 Finished 24th chemo treatment
7/15/10 PET/CT showed excellent response in nodes and breast; possible bone mets
7/16/10 Began Herceptin@ 3 wks and Zometa @6 wks plus Lupron and Femera
7/29/10 Diagnosed with HER+,ER-,PR- skin mets; started Doxil & Cytoxin; no response
11/5/10 PET/CT mets to bone, liver, lung, adrenal; started Xeloda
11/12/10 Brain MRI-Brain Mets, stopped Xeloda, started WBRT 11/16 and Tykerb on 11/19
12/6/10 completed 15 rounds WBRT
12/19/10 restarted Xeloda

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Old 01-22-2011, 02:51 AM   #14
Jackie07
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Re: How fast can skin mets occur

Sharon,

How did it go with your MRI yesterday?
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http://www.kevinmd.com/blog/2011/06/doctors-letter-patient-newly-diagnosed-cancer.html
http://www.asco.org/ASCOv2/MultiMedi...=114&trackID=2

NICU 4.4 LB
Erythema Nodosum 85
Life-long Central Neurocytoma 4x5x6.5 cm 23 hrs 62090 semi-coma 10 d PT OT ST 30 d
3 Infertility tmts 99 > 3 u. fibroids > Pills
CN 3 GKRS 52301
IDC 1.2 cm Her2 +++ ER 5% R. Lmptmy SLNB+1 71703 6 FEC 33 R Tamoxifen
Recc IIB 2.5 cm Bi-L Mast 61407 2/9 nds PET
6 TCH Cellulitis - Lymphedema - compression sleeve & glove
H w x 4 MUGA 51 D, J 49 M
Diastasis recti
Tamoxifen B. scan
Irrtbl bowel 1'09
Colonoscopy 313
BRCA1 V1247I
hptc hemangioma
Vertigo
GI - > yogurt
hysterectomy/oophorectomy 011410
Exemestane 25 mg tab 102912 ~ 101016 stopped due to r. hip/l.thigh pain after long walk
DEXA 1/13
1-2016 lesions in liver largest 9mm & 1.3 cm onco. says not cancer.
3-11 Appendectomy - visually O.K., a lot of puss. Final path result - not cancer.
Start Vitamin D3 and Calcium supplement (600mg x2)
10-10 Stopped Exemestane due to r. hip/l.thigh pain OKed by Onco 11-08-2016
7-23-2018 9 mm groundglass nodule within the right lower lobe with indolent behavior. Due to possible adenocarcinoma, Recommend annual surveilence.
7-10-2019 CT to check lung nodule.
1-10-2020 8mm stable nodule on R Lung, two 6mm new ones on L Lung, a possible lymph node involvement in inter fissule.
"I WANT TO BE AN OUTRAGEOUS OLD WOMAN WHO NEVER GETS CALLED AN OLD LADY. I WANT TO GET SHARP EDGED & EARTH COLORED, TILL I FADE AWAY FROM PURE JOY." Irene from Tampa

Advocacy is a passion .. not a pastime - Joe
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Old 01-22-2011, 09:03 AM   #15
Mary L
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Re: How fast can skin mets occur

Hi Sharon, Just wanted to say hello and send my best wishes to you. You really have been through alot. I hope things settle down and you can start feeling better. I will pray for you and I hope 2011 is a good year for you. Mary L
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Mary L from PA Diag: Oct 2003 w/6mm mass, IDC grade III ductal carcinoma in-situ, IBC stage IIIB. tx A/C followed by Taxotere(only able to have 2 tx, allergic), mastectomy, 3 0ut of 7 positive nodes. 35 rads. Recurrence 9 months later, skin mets to mastectomy site. Tx Carboplatin/Herceptin. Stayed on Herceptin almost 5 years, had 3 more recurrences when I had to stop Herceptin due to my ejection fraction getting too low. Herceptin stopped and ned 3 years in Oct. 2010.
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Old 01-23-2011, 12:56 PM   #16
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Re: How fast can skin mets occur

All:

Thanks for your well wishes. My MRI went well. Preliminary review by the nurse practioner of my films show shrinkage of the brain mets. I will have another MRI in two months to see if I will need any additional brain work.

I also met with my oncologist the week before (Jan 14). After asking me a lot of questions about how I was doing with the new meds, etc., she finally did my physical exam and after looking at my breast became completely choked up because the changes were so dramatically positive. For now, I will continue with both xeloda and tykerb.

I am thankful for the positive changes and now need to work on improving my appetite and work to regain some weight.

Peace,

Sharon
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Momma Sharon

1/7/10 Diagnosed IBC while BF twins a pleomorphic infiltrating lobular carcinoma; 12x9 cm; ER+, PR+, HER-2/neu++; Ki-67 80%
1/25/10 MRI of brain/scan of bone neg-
1/27/10 PET Scan-hypermetabolism in left breast axillary; right mediastinal, left and right supraclavicular and internal mammary lymph nodes
1/29/10 Port Placement, started 24 weeks of chemotherapy with: Trastuzumab- Herceptin, Paclitaxel- Taxol, and Vinorebine- Navelbine
7/9/10 Finished 24th chemo treatment
7/15/10 PET/CT showed excellent response in nodes and breast; possible bone mets
7/16/10 Began Herceptin@ 3 wks and Zometa @6 wks plus Lupron and Femera
7/29/10 Diagnosed with HER+,ER-,PR- skin mets; started Doxil & Cytoxin; no response
11/5/10 PET/CT mets to bone, liver, lung, adrenal; started Xeloda
11/12/10 Brain MRI-Brain Mets, stopped Xeloda, started WBRT 11/16 and Tykerb on 11/19
12/6/10 completed 15 rounds WBRT
12/19/10 restarted Xeloda

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Old 02-08-2011, 09:34 AM   #17
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Red face Re: How fast can skin mets occur

Sharon, how are you doing? I havn't read any new posts and I decided to check on you. I hope the mets are all going away. Let us know how you are. I am praying for you. Mary L
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Mary L from PA Diag: Oct 2003 w/6mm mass, IDC grade III ductal carcinoma in-situ, IBC stage IIIB. tx A/C followed by Taxotere(only able to have 2 tx, allergic), mastectomy, 3 0ut of 7 positive nodes. 35 rads. Recurrence 9 months later, skin mets to mastectomy site. Tx Carboplatin/Herceptin. Stayed on Herceptin almost 5 years, had 3 more recurrences when I had to stop Herceptin due to my ejection fraction getting too low. Herceptin stopped and ned 3 years in Oct. 2010.
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Old 03-07-2011, 03:10 AM   #18
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How fast can skin mets occur

Not to alarm you but, yes I have seen it. My own mother had fibroids but also had a lump that was cancer. Just remember early detection = early cure, so the sooner you get your diagnosis, the sooner you and your physician can decide on the treatment for you and get started on the road to recovery. I wish you all the best. My mother is now 5 years cancer free
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Old 03-08-2011, 07:29 PM   #19
mommaS
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Re: How fast can skin mets occur

Just checking to let everyone know that my cancer markers have decreased significantly over the past two months. I see my oncologist this week and will have my markers measured again. My next brain MRI is March 22. We are hoping for continued positive news on the brain front.

Wellness to you all!

Sharon
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Momma Sharon

1/7/10 Diagnosed IBC while BF twins a pleomorphic infiltrating lobular carcinoma; 12x9 cm; ER+, PR+, HER-2/neu++; Ki-67 80%
1/25/10 MRI of brain/scan of bone neg-
1/27/10 PET Scan-hypermetabolism in left breast axillary; right mediastinal, left and right supraclavicular and internal mammary lymph nodes
1/29/10 Port Placement, started 24 weeks of chemotherapy with: Trastuzumab- Herceptin, Paclitaxel- Taxol, and Vinorebine- Navelbine
7/9/10 Finished 24th chemo treatment
7/15/10 PET/CT showed excellent response in nodes and breast; possible bone mets
7/16/10 Began Herceptin@ 3 wks and Zometa @6 wks plus Lupron and Femera
7/29/10 Diagnosed with HER+,ER-,PR- skin mets; started Doxil & Cytoxin; no response
11/5/10 PET/CT mets to bone, liver, lung, adrenal; started Xeloda
11/12/10 Brain MRI-Brain Mets, stopped Xeloda, started WBRT 11/16 and Tykerb on 11/19
12/6/10 completed 15 rounds WBRT
12/19/10 restarted Xeloda

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Old 03-08-2011, 09:14 PM   #20
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Wink Re: How fast can skin mets occur

Thanks for sharing the wonderful news !!
Keep on putting one foot in front of the other !!
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ElaineM
12 years and counting
http://her2support.org/vbulletin/showthread.php?t=48247
Lucky 13 !! I hope so !!!!!!
http://her2support.org/vbulletin/showthread.php?t=52807
14 Year Survivor
http://her2support.org/vbulletin/showthread.php?t=57053
"You never know how strong you are until being strong is the only choice you have." author unknown
Shared by a multiple myeloma survivor.
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