new targets being discovered for inflammatory bc

[Lani]

this article discusses techniques used to prove the necessity for certain genes/proteins/receptors to maintain growth and invasion of IBC

It also discusses which work in concert, which work as competitors

among the targets (the more specific the target, the less side-effects) are:

EGFR (FDA has already approved drugs)
Amphiregulin (a ligand rather than a receptor), aka AREG
DKK1
RHOB
networks associated with cell motility such as integrin-linked kinase signaling, and focal adhesion kinase signaling.
Wnt signalling
Notch signalling-- there are already trials of a gamma-secretase inhibitor in bc

Hope this helps!